A5031266683- Blood groups and transfusion
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- EFL/ESL Teaching and Learning
- Complement system in diseases
- Eosinophilic Disorders and Syndromes
- COVID-19 Clinical Research Studies
- Cell death mechanisms and regulation
- Second Language Acquisition and Learning
- Cytokine Signaling Pathways and Interactions
- Blood donation and transfusion practices
- Animal Disease Management and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Trace Elements in Health
- Renal Diseases and Glomerulopathies
- Agriculture and Farm Safety
Services Hospital
2024
Banc de Sang i Teixits
2022-2024
Hospital Clínic de Barcelona
2003-2022
Universidad de Salamanca
2019-2021
Georgetown University
2005-2020
Universitat Jaume I
2020
Instituto de Investigación Biomédica de Salamanca
2019
Ministerio de Agricultura, Pesca y Alimentación
2018
National University of Salta
2018
Consejería de Agricultura, Pesca, Agua y Desarrollo Rural
2013-2016
Bcr-Abl–expressing leukemic cells are highly resistant to apoptosis induced by chemotherapeutic drugs. Although a number of signaling molecules have been shown be activated the Bcr-Abl kinase, antiapoptotic pathway triggered this oncogene has not elucidated. Here, we show that interleukin 3-independent expression protein, Bcl-xL, is through activation signal transducer and activator transcription (Stat)5. Inhibition kinase activity in cell lines CD34+ from chronic myelogenous leukemia (CML)...
Erythropoietin (Epo) initiates its cellular response by binding to the Epo receptor, which triggers activation of signal transducer and activator transcription (Stat) 5 protein. Cell culture studies erythroid progenitors have suggested that functions as a survival factor repressing apoptosis at least in part through Bcl-x(L), an anti-apoptotic protein Bcl-2 family. In this report, we examine whether Stat5 can induce transactivation bcl-x gene Epo. Two Epo-responsive progenitor cell lines,...
Deregulating the expression of Bcl-xL, an inhibitor apoptosis, in erythropoietin-dependent erythroblast cell line averts apoptosis induced by withdrawal erythropoietin. Since polycythemia vera abnormal clone erythroid progenitors is independent erythropoietin, we investigated whether endogenous Bcl-xL was deregulated these cells.
BACKGROUND: Red blood cell (RBC) alloimmunization is a major problem in chronically transfused patients because of the risk hemolytic reactions and limited availability compatible blood. This study was aimed at determining characteristics RBC transfusion‐dependent with myelodysplastic syndrome or chronic myelomonocytic leukemia (MDS/CMML). STUDY DESIGN AND METHODS: The transfusion clinical records all MDS/CMML seen our hospital from 1990 to 2009 were reviewed. cumulative incidence calculated...
This study investigated whether the role of working memory capacity varies over course second language (L2) morphosyntactic development. Eighty-seven beginning, intermediate, and advanced university L2 Spanish learners completed two nonverbal tasks measuring executive function (EF) phonological (PWM) in their native (English) knowledge ten grammatical structures at three points during after a semester instruction. Robust relationships between both components, especially PWM, performance,...
Journal Article One Size Fits All? Learning Conditions and Working Memory Capacity in Ab Initio Language Development Get access Cristina Sanz, Sanz * 1 Georgetown University, *E-mail: sanzc@georgetown.edu Search for other works by this author on: Oxford Academic Google Scholar Hui-Ju Lin, Lin 2 Chung Yuan Christian Beatriz Lado, Lado 3 Lehman College, CUNY, Catherine A. Stafford, Stafford 4 University of Wisconsin-Madison, Harriet W. Bowden 5 Tennessee-Knoxville Applied Linguistics, Volume...
Current guidelines recommend that platelets (PLTs) from D- donors should be given to patients. However, such evidence comes studies with a limited number of included patients reported an incidence anti-D alloimmunization up 19%. We thus decided extend these findings by examining at our institution, where PLT transfusions D+ are transfused because logistic constraints.From April 1999 December 2009, we retrospectively reviewed the clinical and transfusion records all who received hospital....
BACKGROUND : In HLA‐alloimmunized patients, the unexpected failure of HLA‐matched platelet transfusions usually raises suspicion about concomitant platelet‐specific antibodies. As reported frequency antibodies in multitransfused patients varies widely, aim this study was to determine prevalence such a population chronic thrombocytopenic with HLA STUDY DESIGN AND METHODS From 1985 1997, 11,777 determinations were performed 1330 hematologic receiving support. Fifty‐two alloimmu‐nization that...
Vox SanguinisEarly View INTERNATIONAL FORUM International Forum on the Use of Irradiated Blood in Patients With Haematological Malignancy: Responses Xiao-Yin Zhang, ZhangSearch for more papers by this authorMichael Murphy, Michael MurphySearch authorGraham P. Collins, Graham CollinsSearch authorVernon J. Louw, Vernon LouwSearch authorGamuchirai Y. Tadzimirwa, Gamuchirai TadzimirwaSearch authorSatyam Arora, Satyam Arora orcid.org/0000-0002-9048-5624 Search authorNita Radhakrishnan, Nita...
BH3‐only proteins are required for execution of apoptotic cell death. We have found that one these proteins, Bik, is strongly induced in cancer cells treated with chemotherapeutic agents. Furthermore, we showed chemotherapy‐induced expression bik independent p53. Consistent its pro‐apoptotic activity, blockade reduces the adriamycin‐mediated also gene transcriptionally activated by E2F proteins. Consistently, adriamycin induces E2F‐bik pathway. In addition, E2Fs transactivate a...
Despite most controlled trials have shown no measurable benefit of COVID-19 convalescent plasma (CCP) in patients with COVID-19, some studies suggest that early administration CCP high-titer anti-SARS-CoV-2 can be beneficial selected patients. We investigated the efficacy to who required hospitalization, STUDY DESIGN AND METHODS: Observational, propensity score (PS) matched case-control study treated within 72 h hospital admission and untreated controls from August 2020 February 2021. All...
BACKGROUND : Previous studies have shown that cooling whole blood to 22°C immediately after collection allows it be held for up 16 hours before component preparation (overnight‐hold method) without a significant decrease in the quality of components obtained. A study was designed evaluate effect overnight‐hold method on growth bacteria experimentally contaminated units. STUDY DESIGN AND METHODS Twenty whole‐blood units were inoculated with Staphylococcus epidermidis (300 colony‐forming...