A5013692799- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Blood transfusion and management
- Hematopoietic Stem Cell Transplantation
- Semiconductor Lasers and Optical Devices
- Complement system in diseases
- GaN-based semiconductor devices and materials
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Blood donation and transfusion practices
- Cell Adhesion Molecules Research
- Parvovirus B19 Infection Studies
- Malaria Research and Control
- Semiconductor Quantum Structures and Devices
- Mast cells and histamine
- Carbon Nanotubes in Composites
- Mosquito-borne diseases and control
- Cytokine Signaling Pathways and Interactions
- Neonatal Health and Biochemistry
- Drug Transport and Resistance Mechanisms
- Cytomegalovirus and herpesvirus research
Japanese Red Cross Society, Japan
2015-2025
Kyoto Prefectural University
2025
Osaka Red Cross Hospital
2005-2022
Tokyo College of Environment
2017
Okayama University
2015
University of Manitoba
2013
New York Blood Center
2013
Osaka City University
2009
Asahi Breweries (Japan)
2008
Osaka University
1989-2008
Background Interleukin (IL)-6–related cytokines share gp130 as the signal-transducing protein. Downstream of gp130, two pathways have been recognized, Janus kinase–signal transducer and activator transcription (JAK-STAT) pathway Ras–mitogen-activated protein kinase (MAPK) pathway. To determine whether these signaling through are present in cardiac myocytes, we examined their activation by using leukemia inhibitory factor (LIF), which is a member IL-6 cytokine family. Methods Results Lysates...
Efforts to identify host determinants for malaria have been hindered by the absence of a nucleus in erythrocytes, which precludes genetic manipulation cell parasite replicates. We used cultured red blood cells derived from hematopoietic stem carry out forward screen Plasmodium falciparum determinants. found that CD55 is an essential factor P. invasion. CD55-null erythrocytes were refractory invasion all isolates because parasites failed attach properly erythrocyte surface. Thus, attractive...
The International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology convened during the congress in Cancun, July 2012. This report details newly identified antigens existing systems presents three new systems.
The International Society of Blood Transfusion (ISBT) Working Party for Red Cell Immunogenetics and Group Terminology meets in association with the ISBT congress has met three times since last report: at international meetings held Dubai, United Arab Emirates, September 2016 Toronto, Canada, June 2018; a regional Copenhagen, Denmark, 2017 an interim session.As previous meetings, matters pertaining to blood group antigen nomenclature classification were discussed. New antigens approved named...
Refractoriness to platelet transfusion is a major problem in small group of patients, and large-scale manufacturing clinical grade functional platelets ex vivo has remained an elusive goal. Sugimoto et al report on the results first trial autologous induced pluripotent stem cell (iPSC)-derived patient who had severe aplastic anemia but no compatible donor. Using methodology described complementary article Blood Advances, provide proof-of-principle illustrate challenges be faced taking this...
Absorption spectra have been measured in the near-infrared region for a thin-film sample of single-wall carbon nanotubes 1.2–1.5 nm diameter. Two absorption peaks are observed at 0.7 and 1.2 eV. The spectrum has compared with calculation based on tight-binding model taking into account distribution diameter helical arrangement tubes. We found that one-dimensional exciton effect plays an important role fundamental optical transition semiconducting nanotubes.
We analyzed the stimulatory effect of oncostatin M (OSM), leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and anti-IL-6 antibody (Ab), receptor monoclonal (mAb), anti-gp130 mAb on growth human plasmacytoma cells freshly isolated from a patient with multiple myeloma. The purified showed plasmacytoid morphology expressed CD38, CD54, CD56 antigens but no CD3, CD5, CD10, CD19, CD20, or very late antigen 5. IL-6 (IL-6R) its signal transducer, gp130, were their cell surface at low...
The Working Party has met twice since the last report: in Seoul, South Korea 2014, and London, UK 2015, both association with International Society of Blood Transfusion (ISBT) Congress. As previous meetings, matters pertaining to blood group antigen nomenclature were discussed. Eleven new antigens added seven systems. This brings current total recognized by ISBT 346, which 308 are clustered within 36 groups remaining 38 currently unassigned a known system.
Protein tyrosine phosphorylation is a common mechanism of signaling in pathways that regulate T cell receptor-mediated activation, proliferation, and the cycle. Because human immunodeficiency virus (HIV) thought to affect normal signaling, may be associated with HIV cytopathicity. In both HIV-infected cells transfected stably express envelope glycoproteins undergoing HIVgp41-induced fusion, 30-kilodalton protein was phosphorylated on kinetics similar those syncytium formation death. When...
The Committee met in Cape Town during the 2006 International Society of Blood Transfusion (ISBT) Congress (see Appendix 1 for members). Some changes to classification documented Group Terminology 2004 [1] were agreed and are described below. full updated can be found on website at http://www.blood.co.uk/ibgrl. New antigens added MNS, Kell, Scianna, Cromer, Indian, Knops, JMH systems (Table 1). In line with convention, amino acid positions numbered translation-initiating methionine as 1,...
The committee met in Macao Special Administrative Region, China, during the 2008 International Society of Blood Transfusion (ISBT) Congress. Some changes to classification documented Group Terminology 2004 [1] and updated 2007 [2] were agreed are described below. full can be found on blood group terminology website at http://www.blood.co.uk/ibgrl. A new system, RHAG was established antigens added Rh, Kell, Dombrock systems (Table 1). total 308 now recognized, 270 which clustered 30 systems....
Abstract Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of cancer initiation and progression remain poorly understood. Here, from expression-based analyses across lineages, we found that melanomas exhibit significant transcriptional changes in glycosylation-related genes. This gene signature revealed that, normal melanocytes, downregulate I-branching glycosyltransferase, GCNT2, leading a loss I-branched...
BACKGROUND Platelet concentrates (PCs) are the most common blood components eliciting nonhemolytic transfusion reactions (NHTRs), such as allergic and febrile reactions. However, precise mechanisms of NHTRs in PC remain largely unknown. Previous studies reported that mitochondria‐derived damage‐associated molecular patterns (DAMPs) could be important mediators innate cell inflammation. Platelets (PLTs) represent a major reservoir mitochondria circulation. The aim this study was to determine...
Under the ISBT, Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens alleles. This report presents outcomes from four WP business meetings, one located in Basel 2019 three held as virtual meetings during COVID-19 pandemic 2020 2021.As previous matters pertaining to antigen nomenclature were discussed. New systems approved named according serologic, genetic, biochemical cell biological evidence presented.Seven new...
Abstract Donor-derived platelets are used to treat or prevent hemorrhage in patients with thrombocytopenia. However, ∼5% more of these complicated alloimmune platelet transfusion refractoriness (allo-PTR) due alloantibodies against HLA-I human antigens (HPA). In cases, from compatible donors necessary, but it is difficult find such for rare HPA. To produce products aplastic anemia allo-PTR HPA-1 mismatch Japan, we developed an ex vivo good manufacturing process (GMP)–based production system...
Abstract Background Reports of cases bacterial infection due to transfusion red blood cell (RBC) components (RBC‐TTBI) are relatively rare. Hence, the possibility undetectable contamination in RBCs, especially by psychrotrophic bacteria, must be clarified. Study Design and Methods We assessed nine species, including those implicated bacteremia or RBC‐TTBIs. They were cultured on plates from 4 37°C determine their optimal growth temperatures. also detection capabilities automated...
Ethylene is a gaseous plant hormone that regulates various aspects of growth and development. It promotes shoot in etiolated rice seedlings, which crucial for seedling establishment has significant agricultural implications. Of the five ethylene receptors rice, OsERS1 most abundantly expressed seedlings. Therefore, we investigated localization role growth. When protoplasts, was localized endoplasmic reticulum. Knockout mutants exhibited enhanced seedlings under normal ethylene-treated...
Venipuncture is a commonly performed procedure to obtain blood for testing or donation, but nerve injuries with persistent chronic pain can occasionally occur. We implemented Phalen elbow flexion shoulder abduction (PEFSA) test screen potential donors who may be at risk after donation. Data were prospectively collected on all Red Cross centers in Kansai area of Japan 5 years prior PEFSA implementation, and then 2 implementation. Potential had positive given handout informing them potentially...