A5050787543- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Blood donation and transfusion practices
- Neonatal Health and Biochemistry
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Microbial infections and disease research
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Malaria Research and Control
- Blood transfusion and management
- Hepatitis B Virus Studies
- Blood properties and coagulation
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
Lund University
2015-2024
Seattle University
2016-2020
Institute for Stem Cell Biology and Regenerative Medicine
2020
Institute for Transfusion Medicine
2003-2018
Emerald Coast Science Center
2018
Hudson Institute
2016
John Wiley & Sons (United States)
2016
Iowa City Public Library
2016
Universitätsmedizin Greifswald
2009
New York Blood Center
1996-2008
Key Points We extracted 210 412 blood group alleles (∼8.5 × 109 bp) from 1000 Genomes and matched them against official reference lists. Of 1241 nonsynonymous variants found, 241 are known polymorphisms while may represent undiscovered or altered antigens.
The International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology convened during the congress in Cancun, July 2012. This report details newly identified antigens existing systems presents three new systems.
The International Society of Blood Transfusion (ISBT) Working Party for Red Cell Immunogenetics and Group Terminology meets in association with the ISBT congress has met three times since last report: at international meetings held Dubai, United Arab Emirates, September 2016 Toronto, Canada, June 2018; a regional Copenhagen, Denmark, 2017 an interim session.As previous meetings, matters pertaining to blood group antigen nomenclature classification were discussed. New antigens approved named...
The Working Party has met twice since the last report: in Seoul, South Korea 2014, and London, UK 2015, both association with International Society of Blood Transfusion (ISBT) Congress. As previous meetings, matters pertaining to blood group antigen nomenclature were discussed. Eleven new antigens added seven systems. This brings current total recognized by ISBT 346, which 308 are clustered within 36 groups remaining 38 currently unassigned a known system.
Abstract Shiga toxin (Stx)-producing Escherichia coli (STEC) cause hemolytic uremic syndrome (HUS). This study investigated whether Stx2 induces hemolysis and complement is involved in the process. RBCs and/or RBC-derived microvesicles from patients with STEC-HUS (n = 25) were for presence of C3 C9 by flow cytometry. Patients exhibited increased deposition on compared controls (p < 0.001), as well high levels C3- C9-bearing during acute phase, which decreased after recovery. bound to...
The Committee met in Cape Town during the 2006 International Society of Blood Transfusion (ISBT) Congress (see Appendix 1 for members). Some changes to classification documented Group Terminology 2004 [1] were agreed and are described below. full updated can be found on website at http://www.blood.co.uk/ibgrl. New antigens added MNS, Kell, Scianna, Cromer, Indian, Knops, JMH systems (Table 1). In line with convention, amino acid positions numbered translation-initiating methionine as 1,...
Under the ISBT, Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens alleles. This report presents outcomes from four WP business meetings, one located in Basel 2019 three held as virtual meetings during COVID-19 pandemic 2020 2021.As previous matters pertaining to antigen nomenclature were discussed. New systems approved named according serologic, genetic, biochemical cell biological evidence presented.Seven new...
Abstract Background and Objectives Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as groups human platelet or neutrophil antigens. CD36 is widely considered a antigen (Nak ) anti‐CD36 can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) in CD36‐negative pregnant women. used marker differentiation early erythroid culture. During experimental culture CD34+ from random donors, we observed that one individual lacked CD36. We sought to...
BACKGROUND: In the Duffy blood group system, null phenotype Fy(a–b–) has been classically associated with a mutated GATA box, while Fy x weak b is Arg89Cys and Ala100Thr mutations. This report assesses prevalence of box ‐associated mutations in white African American (black) donors investigates molecular mechanism underlying phenotype. STUDY DESIGN AND METHODS: PCR RFLP genotyping was performed on samples from blacks whites. antigen expression (Fy , Fy6, Fy3) RBCs measured by flow cytometry....
The Bloodgen project was funded by the European Commission between 2003 and 2006, involved academic blood centres, universities, Progenika Biopharma S.A., a commercial supplier of genotyping platforms that incorporate glass arrays. has led to development commercially available product, BLOODchip, can be used comprehensively genotype an individual for all clinically significant groups. intention making this system is services perhaps even hospital banks would able obtain extended information...
BACKGROUND: The S–s–U– phenotype in African Americans is due to a GYPB deletion, however the molecular basis for S–s–U+ var poorly understood. Variable reactivity of RBCs with monoclonal anti‐He or by anti‐U has been demonstrated, underlying bases this remain be established. STUDY DESIGN AND METHODS: Hemagglutination was performed on 104 S–s– blood samples using and anti‐U. sequenced from selected samples. Allele exon‐specific PCR analysis used identify wild‐type mutant alleles. RESULTS:...
Several red cell storage properties were evaluated following phototreatment with methylene blue (MB) under conditions that inactivated > or = 6 log10 of added vesicular stomatitis virus. Red 2,3 DPG levels similar to untreated controls throughout conventional 42‐day at 4 degrees C. Plasma hemoglobin elevated approximately twofold in MB‐phototreated samples, and morphology scores 5 percent lower after storage. ATP declined 30 phototreated samples a control sample containing MB not exposed...
Background : Previous studies explored the feasibility of using photosensitizer methylene blue (MB) as a virucidal agent in red cell suspensions. Under treatment conditions (5 μ M [5 μmol/L] MB, 3.4 × 10(4) J/m 2 ) that resulted more than 6 log 10 inactivation vesicular stomatitis virus (VSV) or enveloped bacteriophage φ6, membrane alterations were observed. Increased ion permeability and binding plasma proteins to surface most sensitive indicators, which varied dose‐dependent fashion. Study...
The Bombay and para-Bombay phenotypes arise from mutations of the FUT1 gene that silence or affect efficiency encoded 2-alpha-fucosyltransferase. Samples seven individuals different geographic backgrounds whose red blood cells had an apparent phenotype were investigated. Among these, novel FUT2 alleles identified.Standard serologic techniques used. Genomic DNA was sequenced with primers amplified coding sequence related secretor gene, FUT2. Routine ABO genotyping analysis performed.Five new...
The clinically important MAM blood group antigen is present on haematopoietic cells of all humans except rare MAM-negative individuals. Its molecular basis unknown. By whole-exome sequencing we identify EMP3, encoding epithelial membrane protein 3 (EMP3), as a candidate gene, then demonstrate inactivating mutations in ten known We show that purported tumour suppressor various solid tumours, expressed erythroid cells. Disruption EMP3 by CRISPR/Cas9 gene editing an immortalised human cell line...