A5101978482- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Virus-based gene therapy research
- Vaccine Coverage and Hesitancy
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Medical Research and Treatments
- Gastrointestinal motility and disorders
- Colorectal and Anal Carcinomas
- Eosinophilic Esophagitis
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Hematopoietic Stem Cell Transplantation
- Gut microbiota and health
- Phagocytosis and Immune Regulation
Southern University of Science and Technology
2020-2025
Royal Anthropological Institute
2025
Shanghai Ocean University
2025
Dhurakij Pundit University
2025
Southeast University
2022-2024
Shenzhen Third People’s Hospital
2020-2024
Oxford University Hospitals NHS Trust
2016-2024
Churchill Hospital
2024
University of Oxford
2012-2024
Anhui University
2023
Abstract Faced with challenging cases, doctors are increasingly seeking diagnostic advice from large language models (LLMs). This study aims to compare the ability of LLMs and human physicians diagnose cases. An offline dataset 67 cases primary gastrointestinal symptoms was used solicit possible diagnoses seven 22 gastroenterologists. The by Claude 3.5 Sonnet covered highest proportion (95% confidence interval [CI]) instructive (76.1%, [70.6%–80.9%]), significantly surpassing all...
Abstract Background Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by exposure to antibiotics reveals potential therapeutic role fecal microbiota transplantation (FMT) in these Herein, we aimed evaluate safety and benefit rescue FMT AAD Methods A series patients with received from Chinese fmtBank, September 2015 February 2019. Adverse events (AEs) success which focused on improvement abdominal symptoms post-ICU...
INTRODUCTION: Vagal nerve stimulation (VNS) can be used to modulate gastrointestinal motility, inflammation, and nociception. However, it remains unclear whether VNS is effective in adult patients with functional dyspepsia (FD). We investigated the effectiveness of transcutaneous auricular (taVNS) FD. METHODS: Consecutive FD meeting Rome IV criteria modified Symptom Diary score ≥10 were enrolled. Patients randomly allocated 10-Hz taVNS (V10 group), 25-Hz (V25 or sham group, 30 minutes...
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors immunoarchitectural patterns (IAPs) for all stages pediatric adult patients with NLPHL.
Antibody persistence and safety up to 12 months of heterologous orally administered adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in individuals who were primed with two-dose inactivated SARS-CoV-2 (CoronaVac) previously, has not been reported yet. This randomized, open-label, single-centre trial included Chinese adults have received CoronaVac randomized low-dose or high-dose aerosolised Ad5-nCoV group, group. In this report, we mainly evaluated the geometric mean titres (GMTs)...
Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure extremely high doses of radiation and crosslinking agents. These agents form highly toxic crosslinks that cause extensive damage. However, little is known about how the other "extremophiles" tolerate repair such large numbers crosslinks. Here we describe a comprehensive genetic analysis crosslink in discoideum. We analyse three gene groups are crucial for replication-coupled process...
The National Comprehensive Cancer Network recommends conservative follow-up for gastric gastrointestinal stromal tumors (GISTs) less than 2 cm. We have previously reported that the mitotic index of 22.22% small GISTs exceeded 5 per 50 high-power fields and recommended all should be resected once diagnosed. aim present study is to compare safety outcomes endoscopic open resection GISTs. From May 2010 March 2014, a total 90 GIST patients were enrolled in study, including 40 who underwent...
Burkitt lymphoma (BL) has unique biology and clinical course but lacks a standardized prognostic model. We developed validated novel index specific for BL to aid risk stratification, interpretation of trials, targeted development treatment approaches.We derived the International Prognostic Index (BL-IPI) from real-world data set adult patients with treated immunochemotherapy in United States between 2009 2018, identifying candidate variables that showed strongest association progression-free...
Helicobacter pylori infection is a prevalent infectious disease, associated with many gastric diseases, including gastritis, ulcer, and cancer. To reveal the characteristics of microbiome in patients infected H. , we performed metagenomic shotgun sequencing stomach swab samples from 96 then conducted association analyses between alterations status. The overall composition microbiota pylori‐infected individuals was distinctly different negative controls; became dominant species after...
Abstract Here, we investigated the role of zinc ribbon domain-containing 1 (ZNRD1) in multidrug resistance (MDR) leukemia cells and possible underlying mechanisms. ZNRD1 was found overexpressed vincristine-induced MDR cell HL-60/vincristine moreso than its parental HL-60. Up-regulation expression could confer both P-glycoprotein (P-gp)-related P-gp-nonrelated drugs on HL-60 suppress Adriamycin-induced apoptosis accompanied by decreased accumulation increased releasing amount Adriamycin....
Objectives To evaluate the safety and immunogenicity of adenovirus type 5 vectored COVID-19 vaccine (Ad5-nCoV), by intradermal immunization with a needle-free injector in rats. Methods This study was divided into two parts. In A, 105 rats were randomly assigned to seven groups, receive low-dose, medium-dose, or high-dose injections (NFI), needle-based intramuscular (NI), saline solution as control group. Blood samples collected on day 0 before vaccination, 7, 14, 21 28 after vaccination....
This paper discusses how complexity theory may help in optimizing military strategy and planning times of growing uncertainty complexity. The research establishes a theory-based framework enhanced by genetic algorithm-based strategic filtering to improve adaptability within operations. While this approach offers valuable insights, its implementation existing structures faces practical challenges. These include organizational resistance non-traditional decision-making processes, limited...
ABSTRACT Objective With the advancement of digital orthopedics, growing prevalence medial compartment knee osteoarthritis (MCKOA) and widespread adoption knee‐preserving surgical techniques have heightened new interest in predicting onset MCKOA promoting outcomes. This study was to clarify differences kinematics contact patterns between its native sides during extension. Methods From March 2023 June 2024, thirty‐two patients who suffered from unilateral MCKOA, with their contralateral...
Vox SanguinisEarly View INTERNATIONAL FORUM International Forum on the Use of Irradiated Blood in Patients With Haematological Malignancy: Responses Xiao-Yin Zhang, ZhangSearch for more papers by this authorMichael Murphy, Michael MurphySearch authorGraham P. Collins, Graham CollinsSearch authorVernon J. Louw, Vernon LouwSearch authorGamuchirai Y. Tadzimirwa, Gamuchirai TadzimirwaSearch authorSatyam Arora, Satyam Arora orcid.org/0000-0002-9048-5624 Search authorNita Radhakrishnan, Nita...
ABSTRACT Objective The objective of this study was to investigate the efficacy transcutaneous auricular vagal nerve stimulation (taVNS) in adult patients with chronic constipation. Design Consecutive who met Rome IV criteria for constipation were enrolled and randomly assigned either taVNS group or sham‐taVNS group. Treatment consisted 30 min therapy twice a day 4 weeks. primary outcome response rate at week 1–4, defined as proportion weekly complete spontaneous bowel movement (CSBM) ≥ 3...
This paper discusses the development of dynamics in Israel-Iran conflict, with a forecastfor 2024, using military wisdom inspired by Sun Tzu's Art War combination withgenetic algorithms and complexity theory. The research points out how variety strategiesundertaken result combat resource consumption, morale, changes international politics, creation multisegmented simulation war between Israel Iran. Theresearch methodology includes genetic algorithm that optimizes strategies,...
Cellular retinoic acid-binding protein 1 (CRABP1) is highly expressed in motor neurons. Degenerated neuron-like MN1 cells are engineered by introducing SODG93A or AR-65Q to model degenerated amyotrophic lateral sclerosis (ALS) spinal bulbar muscular atrophy Retinoic acid (RA)/sonic hedgehog (Shh)-induced embryonic stem differentiation into neurons employed study up-regulation of Crabp1 Shh. In neurons, CRABP1 level reduced, revealing a correlation neuron degeneration with down-regulation....