A5100625910- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Organ Transplantation Techniques and Outcomes
- RNA Interference and Gene Delivery
- Developmental Biology and Gene Regulation
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Hedgehog Signaling Pathway Studies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Eicosanoids and Hypertension Pharmacology
- Hepatitis Viruses Studies and Epidemiology
Xijing Hospital
2014-2024
Air Force Medical University
2014-2024
National Clinical Research Center for Digestive Diseases
2017-2024
Nanjing Drum Tower Hospital
2023
State Key Laboratory of Cancer Biology
2006-2009
Objective Limited data are available on the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis (PVT). This study aimed to compare transjugular intrahepatic portosystemic shunt (TIPS) covered stents versus endoscopic band ligation (EBL) plus propranolol for among cirrhosis and PVT. Design Consecutive (94% Child-Pugh class A or B) PVT who had bleeding past 6 weeks were randomly assigned TIPS group (n=24) EBL (EBL+drug, n=25), respectively. Primary endpoint was...
Cellular prion protein (PrPc) is a glycosylphosphatidylinositol (GPI) -anchored membrane that highly conserved in mammalian species. PrPc has the characteristics of adhesive molecules and thought to play role cell adhesion signaling. Here we investigated possible process invasiveness metastasis gastric cancers. was found be expressed metastatic cancers compared nonmetastatic ones by immunohistochemical staining. significantly promoted adhesive, invasive, vivo abilities cancer lines SGC7901...
MicroRNAs play essential roles in gene expression regulation during carcinogenesis. Here, we investigated the role of miR-7 and mechanism by which it is dysregulated gastric cancer (GC). We used genome-wide screenings identified RELA FOS as novel targets miR-7. Overexpression repressed prevented GC cell proliferation tumorigenesis. These effects were clinically relevant, low was correlated with high poor survival patients. Intriguingly, found that indirectly regulated activation targeting...
Colorectal cancer (CRC) frequently harbors KRAS mutations that result in chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated play important regulatory roles tumor progression. However, the mutation-responsive miRNA profile CRC remains uninvestigated.
A growing amount of evidence indicates that miRNAs are important regulators multiple cellular processes and, when expressed aberrantly in different types cancer such as hepatocellular carcinoma (HCC), play significant roles tumorigenesis and progression. Aberrant expression miR-199a-5p (also called miR-199a) was found to contribute carcinogenesis cancer, including HCC. However, the precise molecular mechanism is not yet fully understood. The present study showed miR-199a frequently...
The p75 neurotrophin receptor (p75NTR) is a focus for study at present. However, its function in gastric cancer was not elucidated. Here, we investigated relation with metastasis of cancer. By immunohistochemistry, found that the positive rate p75NTR expression metastatic 15.09% (16 106), which lower compared nonmetastatic (64.15%; 68 106). average staining score significantly higher than (1.21 +/- 0.35 versus 0.23 0.18; P<0.01). protein level also lowly expressed highly liver-metastatic...
Upregulated gene 4 (URG4), a novel located on 7 chromosome (7p13), was found to contribute hepatocarcinogenesis. However, the role of URG4 in gastric carcinogenesis still remains unclear. In present study, by immunohistochemistry be upregulated human cancer tissues compared with matched adjacent nonneoplastic tissues. The proliferating cell nuclear antigen index is higher high expression than those low expression. growth GES-1 cells, which are immortalized epithelial mucosa cells baseline...
Osteopontin (OPN), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are overexpressed in various experimental models of malignancy. However, the correlation role three molecules gastric cancer is unclear. In present study, we found that OPN, COX-2 VEGF were 53 cancerous tissues with compared 40 normal mucosa by immunohistochemistry method. Moreover, results indicated co-expression COX-2, cancer. Levels all significantly correlated TNM stage, lymph node metastasis...
Summary Background In patients with idiopathic non‐cirrhotic portal hypertension (INCPH), the usual recommended strategy for management of variceal bleeding is same as that in cirrhosis. However, this policy has been challenged by different natural history between INCPH and Aim To compare outcomes after transjugular intrahepatic portosystemic shunt (TIPSS) cirrhotic admitted bleeding. Methods Between March 2001 September 2015, 76 consecutive biopsy‐proven undergoing TIPSS a tertiary‐care...
Objective: The systemic inflammation index and body mass (BMI) are easily accessible markers that can predict mortality.However, the prognostic value of combined use these two remains unclear. goal this study was therefore toevaluate association with outcomes based on a large cohort patients gastric cancer. Methods: A total 2,542 consecutive undergoing radical surgery for or gastroesophageal junction adenocarcinomabetween 2009 2014 were included. Systemic quantified by preoperative...
Id-1 is a member of the helix-loop-helix protein family and involved in multiple biological processes, including development, proliferation, angiogenesis carcinogenesis. However, role hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) still unclear. In this study, expression 96 tumor specimens HBV-related HCC was detected by immunohistochemical (IHC) staining. The relationship between grade patient clinicopathological features studied. addition, disease-free overall survival...