A5101612753- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Cancer Research and Treatments
- Gallbladder and Bile Duct Disorders
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- Fibroblast Growth Factor Research
- Mechanisms of cancer metastasis
- Proteoglycans and glycosaminoglycans research
Xijing Hospital
2013-2023
Air Force Medical University
2013-2023
Eastern Hepatobiliary Surgery Hospital
2019
Second Military Medical University
2019
Military University
2012
General Hospital of Shenyang Military Region
2008
117th Hospital of People's Liberation Army
2007
Although the primitive haematopoietic and neuronal stem cell marker CD133 is known to be present in cancer cells (CSCs) hepatocellular carcinoma (HCC), postresection prognostic impact of HCC patients remains limited.Sixty-three resected specimens were collected from patients. The expression protein was analysed by immunohistochemistry association with clinicopathological characteristics, tumour recurrence survival evaluated.Immunohistochemical analysis 63 tissue revealed that positive...
The MYC oncogene is overexpressed in hepatocellular carcinoma (HCC) and has been associated with widespread microRNA (miRNA) repression; however, the underlying mechanisms are largely unknown. Here, we report that c-Myc oncogenic transcription factor physically interacts enhancer of zeste homolog 2 (EZH2), a core enzymatic unit polycomb repressive complex (PRC2). Furthermore, miR-101, an important tumor-suppressive miRNA human hepatocarcinomas, epigenetically repressed by PRC2 c-Myc-mediated...
Long non-coding RNAs (lncRNAs) have previously been implicated in human disease states, especially cancer.Although the aberrant expression of lncRNAs has observed cancer, biological functions and molecular mechanisms underlying aberrantly expressed hepatocellular carcinoma (HCC) not widely established.In present study, we investigated a novel lncRNA, termed URHC (up-regulated carcinoma), evaluated its role progression HCC.Expression profiling using lncRNA microarray revealed that was highly...
Abstract Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic diseases lacks effective treatment. Tamoxifen has been proven to be the first-line chemotherapy for several solid tumors in clinics, however, its therapeutic role NAFLD never elucidated before. In vitro experiments, tamoxifen protected hepatocytes against sodium palmitate-induced lipotoxicity. male and female mice fed with normal diets, continuous administration inhibited lipid accumulation liver, improved...
Hepatic ischemia/reperfusion (I/R) injury is initiated by reactive oxygen species (ROS) accumulated during the early reperfusion phase after ischemia, but cellular mechanisms controlling ROS production and scavenging have not been fully understood. In this study, we show that blocking Notch signal knockout of transcription factor RBP-J or a pharmacological inhibitor led to aggravated hepatic I/R injury, as manifested deteriorated liver function increased apoptosis, necrosis, inflammation,...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and it carries a poor prognosis due to high rate recurrence or metastasis after surgery. Bmi-1 plays significant role in growth many solid tumours. However, exact mechanisms underlying Bmi-1-mediated cell invasion metastasis, especially HCC, are not yet known. In present study, we sought evaluate expression HCC samples its relationship with clinicopathological characteristics prognostic value, also investigated...
// Yuan Gao 1,* , Bai Ruan Weihui Liu 2,* Jianlin Wang 1 Xisheng Yang Zhuochao Zhang Xia Li Juanli Duan Fuqing Rui Ding Kaishan Tao and Kefeng Dou Department of Hepato-Biliary Pancreto-Splenic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China 2 General Surgery Center PLA, Chengdu Chengdu, * These authors contributed equally to this work Correspondence to: Dou, email: Tao, Ding, Keywords : CD44, Hepatocellular carcinoma, epithelial-mesenchymal-transition, Snail...
The objective of this study was to evaluate the efficacy combined therapy using Sorafenib and radiofrequency ablation (RFA) with curative intent for all detectable lesions in patients Barcelona Clinic Liver Cancer (BCLC) Stage 0-B1 hepatocellular carcinoma (HCC).One hundred twenty-eight HCC from 12 centers were enrolled retrospective study; 64 who received plus RFA (Sorafenib-RFA) compared a control group treated alone. two patient groups selected predefined criterion matched terms their...
A safe and effective in vivo siRNA delivery system is a prerequisite for liver tumor treatment based on cancer therapeutics. Nanoparticles superparamagnetic iron oxide (SPIO) provide promising system. In this study, we aimed to explore novel nanoparticle, which composed of SPIO.The particles have core that modified by galactose (Gal) polyethylenimine (PEI), act as shells, providing targeted therapeutic the cancer. Gal-PEI-SPIO nanoparticles were synthesized, characteristics encapsulated with...
Background The prognosis for patients with hepatocellular carcinoma (HCC) is poor, and the mechanisms underlying development of HCC remain unclear. Notch1 Notch3 may be involved in malignant transformation, although their roles unknown. Materials Methods tissues were stained anti-Notch1 or -Notch3 antibody. migration invasion capacities cells measured transwell cell culture chambers. RT-PCR was used to measure expression mRNA. Additionally, western blot analysis assess protein Notch1,...
It has been reported that Annexin A2 (ANXA2) is up-regulated in hepatocellular carcinoma (HCC), but the roles of ANXA2 migration and invasion HCC cells have not determined. In this study, we found ANXA2-specific siRNA (si-ANXA2) significantly inhibited co-cultured with fibroblasts vitro. addition, production MMP-2 by cultured supernatant collected from si-ANXA2-transfected was notably down-regulated. also to be co-localized co-immunoprecipitated CD147. Further investigation revealed...
HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study demonstrated that overexpression of promotes interacting with integrin alpha3beta1. However, it has never been investigated whether alpha3beta1 is solely responsible for this process or if other family members also interact human cells.Human SMMC-7721 and FHCC98 cells were cultured transfected siRNA fragments against HAb18G/CD147. The expression levels alpha6beta1...
Abstract The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in play crucial roles metastasis process. Shifting tumor-promoting M2-like TAMs toward M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and secretion inhibitory factors, may be a potential therapeutic strategy cancer treatment. We first cloned NDRG2 (N-myc downstream-regulated gene 2) verified its role multiple solid tumors, including...
Several studies have found that centromere protein K (CENPK) is overexpressed in several tumour types and promotes tumor progression. However, there has been little research on the role of CENPK progression hepatocellular carcinoma (HCC).The expression HCC tissues was quantified by Western blot quantitative real-time PCR. Cells were transfected with lentiviral plasmids containing shRNA sequences targeting YAP1 to silence YAP1. Cell Counting Kit-8 assay, colony formation wound healing...
Cell division cycle associated 5 (CDCA5) has been with the progression of several types cancers. However, its possible role and mechanism in hepatocellular carcinoma (HCC) remain unknown. In present study, immunohistochemical staining real‑time PCR were used to assess CDCA5 protein mRNA levels clinical samples. Statistical analysis was performed explore correlation between expression clinicopathological features overall survival HCC patients. counting colony formation assays employed analyse...
Thyroid hormones are essential for the maturation and functions of central nervous system. Pain sensitivity is related to thyroid status. However, information on how affect pain processing synaptic transmission in anterior cingulate cortex (ACC) limited. Nociceptive threshold ACC were detected experimental hypothyroidism (HT) mice.HT was induced by methimazole potassium perchlorate distilled drinking water 4 weeks. The perception hot insults, but not mechanical ones, decreased hypothyroid...