Abstract Sepsis is a life‐threatening organ dysfunction syndrome, and liver susceptible target in sepsis, because the activation of inflammatory pathways contributes to septic injury. Oxidative stress has been documented participate injury, it not only directly induces oxidative genotoxicity, but also exacerbates potentiate damage liver. Therefore, ameliorate promising for protecting sepsis. Wogonin compound extracted from medicinal plant Scutellaria baicalensis Geogi was found exert...

HAb18G/CD147, a member of the immunoglobulin family enriched on surface tumor cells, is reported to be correlated with invasion, metastasis, growth, and survival malignant cells. Here, we found that annexin II, 36‐kDa Ca 2+ ‐ phospholipid‐binding protein in vivo substrate for tyrosine kinase PKC, new interaction HAb18G/CD147 human hepatocellular carcinoma (HCC) In present study, explored unclear role annxin II HCC invasion migration effects between II. Our data show downregulation cells...

The occurrence of neutrophils at the pannus-cartilage border is an important phenomenon for understanding pathogenesis rheumatoid arthritis (RA). Matrix metalloproteinases (MMPs) are predominant enzymes responsible cartilage degradation. present article studied expression CD147 on and its potential role in neutrophil chemotaxis, MMPs production invasiveness fibroblast-like synoviocytes (FLS). results flow cytometry revealed that mean fluorescence intensity peripheral blood from RA patients...

HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study demonstrated that overexpression of promotes interacting with integrin alpha3beta1. However, it has never been investigated whether alpha3beta1 is solely responsible for this process or if other family members also interact human cells.Human SMMC-7721 and FHCC98 cells were cultured transfected siRNA fragments against HAb18G/CD147. The expression levels alpha6beta1...

Rheumatoid arthritis (RA) is an inflammatory and angiogenic disease. However, the molecular mechanisms that promote angiogenesis in RA have not been clearly identified. Our objective was to study role of CD147 determine whether strategy which suppressed might be useful reducing RA.Correlations among expression levels CD147, vascular endothelial growth factor (VEGF), hypoxia-inducible 1α (HIF-1α) were determined by immunohistochemistry staining. fibroblast-like synoviocytes (FLS) cells...

Recent genome-wide association studies (GWAS) have identified several common susceptibility loci associated with the risk of colorectal cancer (CRC). However, whether these affect clinical outcomes CRC is not clear. In this study, we genotyped 26 single nucleotide polymorphisms (SNPs) in 10 GWAS-identified regions and evaluated their associations survival recurrence 285 stage II III patients receiving fluorouracil-based adjuvant chemotherapy. Only one SNP, rs10318 (15q13.3), was...

Androgen receptor (AR) levels are regulated by androgens, other steroids and non-steroidal hormones via complex, tissue-specific processes. Since alterations in may influence cellular sensitivity to understanding AR regulation is of fundamental potentially therapeutic significance. In most target tissues AR-containing cell lines, mRNA down-regulated response androgens. We have reconstituted this androgen-mediated down-regulation COS 1 cells transfected with a human cDNA under the control...

Abstract Hepatocellular carcinoma (HCC) is the malignancy derived from normal hepatocytes with increasing incidence and extremely poor prognosis worldwide. The only approved first‐line systematic treatment agent for HCC, sorafenib, capable to effectively improve advanced HCC patients’ survival. However, it gradually recognized that therapeutic response sorafenib could be drastically diminished after short‐term treatment, defined as primary resistance. present study aimed explore role of...

AIM: To investigate decisional conflict among patients diagnosed with primary angle-closure suspect (PACS) or (PAC) who are considering laser peripheral iridotomy (LPI) treatment. METHODS: A total of 111 individuals PACS PAC were selected through convenient sampling from March 2023 to December 2023. These participants then completed a general information questionnaire and the Decision Conflict Scale. Data analysis was performed using multiple linear regression reveal factors influencing...

Sepsis is a systemic inflammatory response syndrome caused by infection, and early management of both the infection excessive key to its treatment. In this study, we designed nanoformulation, termed AuNPs-Mixed, control bacterial modulate response. AuNPs-Mixed was prepared equimolarly combining four nanoparticle formulations, each consisting gold nanoparticles (AuNPs) conjugated separately with mannose-binding lectin (MBL) three different antibodies targeting pro-inflammatory cytokines:...

The regulator of G-protein signaling (RGS) pathway plays an important role in transduction, cellular activities, and carcinogenesis. We hypothesized that genetic variations RGS gene family may be associated with the response late-stage non-small cell lung cancer (NSCLC) patients to chemotherapy or chemoradiotherapy. selected 95 tagging single nucleotide polymorphisms (SNPs) 17 genes genotyped them 598 NSCLC patients. Thirteen SNPs were significantly overall survival. Among them, rs2749786...

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Over-expression of de novo lipogenesis (DNL) pathway genes is associated with the prognosis various types cancers. However, effects single nucleotide polymorphisms (SNPs) in these on recurrence and death hepatocellular carcinoma (HCC) patients after surgery are still unknown. A total 492 primary HCC treated were included this study. Nine SNPs 3 (ACACA, FASN ACLY) DNL genotyped. Multivariate Cox proportional hazard regression model Kaplan-Meier curve used to analyze association clinical...

Osteosarcoma, the most common primary bone tumor in young adults, is characterized by local invasion and distant metastasis. But detailed mechanisms of tumorigenicity metastasis osteosarcoma are not well known. We report involvement calpains, a family calcium-activated, cysteine proteases, invasive metastatic processes human cells. By using siRNA treatment, expression mu- m-calpains were downregulated Saos-2 Both adhesive potentials significantly attenuated calpain siRNA-transfected MMPs...

Abstract Base excision repair (BER) is one of the major cellular DNA pathways that repairs small isolated foci damage including reduced or oxidized single bases fragments and small, non‐bulky adducts. Genetic variations in BER genes may affect capacity increase susceptibility to bladder cancer. In a case–control study 801 cancer patients matched controls, we evaluated associations 167 nucleotide polymorphisms (SNPs) from 19 pathway with risk individual SNP analysis, 13 SNPs 10 were...

The VEGF-independent angiogenic signaling plays an important role in the development of colorectal cancer (CRC). However, its implication clinical outcome CRC has not been reported. This study aimed to investigate association between genetic variations several major pathway genes and overall survival patients.Seven single nucleotide polymorphisms (SNPs) four (ANGPT1, AMOT, DLL4 ENG) were genotyped a Chinese population with 408 patients.One SNP, rs1954727 ANGPT1, was significantly associated...

Previous studies have demonstrated that ATP citrate lyase (ACLY) plays an important role in the development of many cancers. Our current study aims to assess effects functional single nucleotide polymorphisms (SNPs) ACLY gene on recurrence and survival colorectal cancer (CRC) patients. A total 697 resected Chinese CRC patients were included this study. Two examined using Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards model Kaplan-Meier curve used for prognosis...

Self-management plays an important role in the disease management of glaucoma patients. The effectiveness program can be improved by assessing patient's perspective and needs to tailor self-management support. Most studies have focused on one these behaviours, such as medication adherence, there is a lack systematic assessment support challenges for patients with glaucoma. Therefore, this study, we conducted in-depth investigation into primary glaucoma, providing basis nursing staff...

Abstract Cell invasion/migration through three‐dimensional (3D) tissues is not only essential for physiological/pathological processes, but a hallmark of cancer malignancy. However, how to quantify spatiotemporal dynamics 3D cell migration/invasion challenging. Here, this work reports assay (3D‐CIMA) based on electromechanical coupling chip systems, which can monitor in real‐time, label‐free, nondestructive, and high‐throughput way. In combination with topological networks complex impedance...

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Aberrant expression of genes in de novo lipogenesis (DNL) pathway were associated with various cancers, including hepatocellular carcinoma (HCC). Single nucleotide polymorphisms (SNPs) DNL have been reported to be prognosis some malignancies. However, the effects SNPs on overall survival HCC patients receiving transarterial chemoembolization (TACE) treatment are still unknown. In present study, nine three (ACLY, ACACA and FASN) genotyped using Sequenom iPLEX genotyping system a...