A5032513924- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Telomeres, Telomerase, and Senescence
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Health, Environment, Cognitive Aging
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Glutathione Transferases and Polymorphisms
- Nutrition, Genetics, and Disease
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Head and Neck Cancer Studies
- Smoking Behavior and Cessation
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
The University of Texas MD Anderson Cancer Center
2014-2025
Zhejiang University
2020-2025
George Washington University
2024-2025
Zhejiang Cancer Hospital
2024-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
Qiqihar Medical University
2025
Zhejiang Chinese Medical University
2024
Zhejiang Medicine (China)
2024
Chinese Academy of Sciences
2024
Universidad Católica de Santa Fe
2024
On January 20, 2020, a new coronavirus epidemic with human-to-human transmission was officially declared by the Chinese government, which caused significant public panic in China. In light of disease 2019 outbreak, pregnant women may be particularly vulnerable and special need for preventive mental health strategies. Thus far, no reports exist to investigate response outbreak.This study aimed examine impact outbreak on prevalence depressive anxiety symptoms corresponding risk factors among...
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between length and cancer risk four ongoing case–control studies. Methods: All studies had equal numbers of case patients matched control subjects (92 for head neck cancer, 135 bladder 54 lung 32 renal cell carcinoma). Telomere was measured peripheral blood lymphocytes from study participants. assessed comet assay. Patient disease...
BackgroundReliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool by smoking status.
Epigenetic dysregulation has emerged as a major contributor to tumorigenesis. Histone methylation is well-established mechanism of epigenetic regulation that dynamically modulated by histone methyltransferases and demethylases. The pathogenic role modifiers in non-small cell lung cancer (NSCLC), which the leading cause deaths worldwide, remains largely unknown. Here, we found H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 JHDM1A) frequently overexpressed NSCLC tumors lines. its...
Liver function tests (LFTs) have been reported as independent predictors of non-liver disease-related morbidity and mortality in general population cancer patients. In this study, we evaluated the relationship between pretreatment serum LFTs overall survival (OS) non-metastatic Caucasian breast Seven LFTs, including albumin, alanine aminotransferase, aspartate alkaline phosphatase, lactate dehydrogenase (LDH), total bilirubin protein, were measured from 2425 female patients with newly...
BackgroundRisk prediction models for hepatocellular carcinoma are available individuals with chronic hepatitis B virus (HBV) and C (HCV) infections who at high risk but not the general population average or unknown risk. We developed five simple based on clinically data from population.
Abstract Platinum nanoparticles (PtNPs) efficiently catalyze the transformation of H 2 O into oxygen gas. However, owing to lack an efficient approach or device that can measure produced gas, catalytic reaction has never been used for diagnostic applications. Microfluidics technology provides a platform meets these requirements. The volumetric bar‐chart chip (V‐Chip) volumetrically measures production gas by PtNPs and be integrated with ELISA provide visible quantitative readouts without...
We took a polygenic approach to evaluate the effects of 41 potentially functional single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs)-related genes on survival and recurrence among renal cell carcinoma (RCC) patients. During median follow-up 21.8 months, 316 RCC patients, 64 died 56 developed recurrence. In single-SNP analysis, we identified seven SNPs significantly associated with five The most significant associations were GEMIN4 variant alleles both rs7813 rs910925 1.74-fold [95%...
Multiple myeloma (MM) is the second most common haematologic malignancy, presenting a great disease burden on general population; however, quality of care MM overlooked. We therefore assessed gains and disparity in worldwide from 1990 to 2019 based novel summary indicator - index (QCI) examined its potential for improvement.
The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins genetic variations in predicting PCa.
Abstract Background Chronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it identified early and managed effectively. This study aims to develop an advanced COPD diagnostic model by integrating deep learning radiomics features. Methods We utilized dataset comprising CT images from 2,983 participants, of which 2,317 participants also epidemiological data through questionnaires. Deep features were extracted using Variational Autoencoder,...
Abstract The BRCA1 and BRCA2 gene products are thought to play important roles in the processing of DNA damage. To assess whether heterozygous mutations these genes associated with cellular radiosensitivity, we performed an vitro radiation clonogenic survival assay on dermal fibroblasts obtained from 8 sequence‐proven BRCA heterozygotes (6 BRCA1, 2 BRCA2). These data were compared results a previous set 17 prospectively studied cancer patients who had negligible risk for mutation. In...
The authors compared histories of nonmalignant respiratory diseases (asthma, bronchitis, emphysema, hay fever, and pneumonia) in 1,553 lung cancer patients 1,375 healthy controls enrolled a Texas case-control study from 1995 to 2003. They incorporated data on two biologically relevant polymorphic genes, matrix metalloproteinase-1 myeloperoxidase. Emphysema was associated with statistically significant increased risk (odds ratio (OR) = 2.87, 95% confidence interval (CI): 2.20, 3.76), while...
The phosphoinositide-3 kinase (PI3K)–AKT– mammalian target of rapamycin (mTOR) pathway is an important cellular controlling cell growth, tumorigenesis, invasion and drug response. We hypothesized that genetic variations in the PI3K–AKT–mTOR may affect survival muscle invasive metastatic bladder cancer (MiM-BC) patients. conducted a follow-up study 319 MiM-BC patients to systematically evaluate 289 single-nucleotide polymorphisms (SNPs) 20 genes as predicators survival. In multivariate Cox...
The development of second primary tumors (SPT) or recurrence alters prognosis for curatively treated head and neck squamous cell carcinoma (HNSCC) patients. 13-cis-Retinoic acid (13-cRA) has been tested as a chemoprevention agent in clinical trials with mixed results. Therefore, we investigated whether genetic variants the PI3K/PTEN/AKT/mTOR pathway could serve biomarkers to identify which patients are at high risk an SPT/recurrence, while also predicting response 13-cRA chemoprevention.A...
Recent genome-wide association studies (GWAS) have identified several common susceptibility loci associated with the risk of colorectal cancer (CRC). However, whether these affect clinical outcomes CRC is not clear. In this study, we genotyped 26 single nucleotide polymorphisms (SNPs) in 10 GWAS-identified regions and evaluated their associations survival recurrence 285 stage II III patients receiving fluorouracil-based adjuvant chemotherapy. Only one SNP, rs10318 (15q13.3), was...