Christine B. Ambrosone
A5036294770- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Global Cancer Incidence and Screening
- Glutathione Transferases and Polymorphisms
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Gene expression and cancer classification
- Cancer survivorship and care
- Bioinformatics and Genomic Networks
- vaccines and immunoinformatics approaches
- MicroRNA in disease regulation
- Vitamin D Research Studies
- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
- Molecular Biology Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
Roswell Park Comprehensive Cancer Center
2016-2025
SUNY Downstate Health Sciences University
2025
Boston University
2011-2023
University at Buffalo, State University of New York
1994-2023
The University of Texas MD Anderson Cancer Center
2000-2023
Kaiser Permanente
2013-2023
University of Kansas Medical Center
2014-2023
Yale University
2023
Loyola University Medical Center
2023
University of Michigan
2023
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203–213], the presence of CD3 + tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in epithelial ovarian cancer. We performed immunohistochemical analysis for TILs and cancer testis antigens 117 cases The interrelationship between subpopulations expression investigated, as well overall survival. median follow-up patients 31 months. Patients higher frequencies intraepithelial CD8 T cells...
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
Purpose Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing patients. We assessed frequency mutations 17 predisposition genes, including BRCA1 and BRCA2, a large cohort patients with triple-negative (TNBC) unselected family history or ovarian determine utility those TNBC. Patients Methods TNBC (N = 1,824) were recruited through 12 studies, was sequenced identify mutations. Results Deleterious identified 14.6%...
Background To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of breast cancer at an early stage. The occurrence circulating microRNAs (miRNAs) in blood components (including serum plasma) has been repeatedly observed patients as well healthy controls. Because the significance miRNA carcinogenesis, miRNAs may be unique diagnosis human cancers. objective this pilot study was to discover a panel potential novel biomarkers. Methodology/Principal...
A G to C polymorphism (rs2910164) is located within the sequence of miR-146a precursor, which leads a change from G:U pair C:U mismatch in its stem region. The predicted target genes include BRCA1 and BRCA2 , are key breast ovarian cancer genes. To examine whether rs2910164 plays any role and/or cancer, we studied associations between this age diagnosis 42 patients with familial 82 cancer. Breast who had at least one variant allele were diagnosed an earlier than no alleles (median 45 versus...
Abstract Introduction The aim of this study was to describe breast tumor subtypes by common cancer risk factors and determine correlates using baseline data from two pooled prospective studies within a large health maintenance organization. Methods Tumor on 2544 invasive cases subtyped estrogen receptor, progesterone human epidermal growth factor receptor 2 (Her2) status were obtained (1868 luminal A tumors, 294 B 288 triple-negative tumors 94 Her2-overexpressing tumors). Demographic,...
Abstract Summary: The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human genome. Methylation Analyzer (IMA) computational package to automate pipeline exploratory analysis and summarization site-level region-level changes in epigenetic studies utilizing 450K DNA microarray. loads data from platform provides user-customized functions commonly required perform individual as well...
African American (AA) women have a disproportionately high incidence of estrogen receptor–negative (ER-) breast cancer, subtype with largely unexplained etiology. Because childbearing patterns also differ by race/ethnicity, higher parity and lower prevalence lactation in AA women, we investigated the relation to risk specific cancer subtypes. Questionnaire data from two cohort case-control studies were combined harmonized. Case patients classified as ER+ (n = 2446), ER- 1252), or triple...
Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because concerns that some supplements, particularly antioxidants, could reduce the cytotoxicity chemotherapy, we conducted a prospective study ancillary therapeutic trial evaluate associations between supplement and breast outcomes.Patients randomly assigned an intergroup metronomic cyclophosphamide, doxorubicin, paclitaxel were queried on at...
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
Abstract Background Although physical activity has been consistently associated with reduced breast cancer mortality, evidence is largely based on data collected at one occasion. We examined how pre- and postdiagnosis was survival outcomes in high-risk patients. Methods Included were 1340 patients enrolled the Diet, Exercise, Lifestyle Cancer Prognosis (DELCaP) Study, a prospective study of lifestyle prognosis ancillary to SWOG clinical trial (S0221). Activity before diagnosis, during...
Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers1–5. However, variants of uncertain significance limit the utility test results. Thus, there is a need for functional characterization and classification all facilitate management individuals with these variants. Here we analysed possible single-nucleotide from exons 15 26 that encode DNA-binding domain hotspot pathogenic missense To enable this, used saturation...
To determine if N-acetyltransferase 2 (NAT2) polymorphisms result in decreased capacity to detoxify carcinogenic aromatic amines cigarette smoke, thus making some women who smoke more susceptible breast cancer.Case-control study with genetic analyses. DNA analyses were performed for 3 accounting 90% 95% of the slow acetylation phenotype among whites.White incident primary cancer (n=304) and community controls (n=327).Neither smoking nor NAT2 status was independently associated risk. There no...
Abstract Currently available serum biomarkers are insufficiently reliable to distinguish patients with epithelial ovarian cancer (EOC) from healthy individuals. Metabonomics, the study of metabolic processes in biologic systems, is based on use 1 H‐NMR spectroscopy and multivariate statistics for biochemical data generation interpretation may provide a characteristic fingerprint disease. In an effort examine utility metabonomic approach discriminating sera women EOC controls, we performed...
Abstract Abstract: Cruciferous vegetables contain anticarcinogenic isothiocyanates (ITCs), particularly the potent sulforaphane, which may decrease risk of prostate cancer through induction phase II enzymes, including glutathione S-transferases (GSTs). We evaluated this hypothesis in a population-based, case-control study cancer, 428 men with incident and 537 community controls. An in-person interview included an extensive food-frequency questionnaire. Genotyping for deletions GSTM1 GSTT1...