Xiaofeng Zhu
A5007766399- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Obstructive Sleep Apnea Research
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Sleep and related disorders
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Obesity, Physical Activity, Diet
- Hormonal Regulation and Hypertension
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- interferon and immune responses
- Cardiovascular Disease and Adiposity
- Lung Cancer Treatments and Mutations
- Cognitive Abilities and Testing
Case Western Reserve University
2016-2025
Nanjing Medical University
2023-2025
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
Huaian First People’s Hospital
2024-2025
Quantitative BioSciences
2023-2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Huashan Hospital
2021-2025
Fudan University
2021-2025
Obesity is a heritable trait and risk factor for many common diseases such as type 2 diabetes, heart disease, hypertension. We used dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify genetic variant near INSIG2 gene associated with obesity. have replicated finding in four separate composed individuals Western European ancestry, African Americans, children. The obesity-predisposing genotype present 10% individuals. Our study suggests that...
Abstract Oilseed crops are used to produce vegetable oil. Sesame ( Sesamum indicum ), an oilseed crop grown worldwide, has high oil content and a small diploid genome, but the genetic basis of production quality is unclear. Here we sequence 705 diverse sesame varieties construct haplotype map genome de novo assemble two representative identify variations. We investigate 56 agronomic traits in four environments 549 associated loci. Examination major loci identifies 46 candidate causative...
The copolymerization of carbon dioxide (CO2) and epoxides to produce aliphatic polycarbonates is a burgeoning technology for the large-scale utilization CO2 degradable polymeric materials. Even with wealth advancements achieved over past 50 years on this green technology, many challenges remain, including use metal-containing catalysts polymerization, removal chromatic metal residue after limited practicable epoxides, especially those containing electron-withdrawing groups. Herein, we...
Spielman et al. [1993] proposed a transmission-disequilibrium test (TDT), based on marker data collected affected offspring and their parents, to for linkage between genetic binary trait provided there is allelic association. It has been shown that this TDT powerful not by association due population stratification in the absence of linkage. For quantitative traits, George Elston [1987] likelihood method detect effect candidate gene pedigree when familial correlations are present. This will...
Background— The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes. Method Results— This genotype-phenotype genetic association study included replication samples genomic control correct for population stratification. Sequencing of the human corin gene identified 2 nonsynonymous, nonconservative single nucleotide...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) Herbert and colleagues. The association between increased BMI homozygosity for minor allele first observed in data from a genome-wide scan 86,604 SNPs 923 related individuals Framingham Heart Study offspring cohort. reproduced four additional cohorts, but not seen fifth To further assess general reproducibility this association, we genotyped rs7566605 nine large...
While genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent often involve additional populations, including admixed such as African Americans and Latinos. In linkage disequilibrium (LD) exists both at a fine scale in ancestral coarse (admixture-LD) due to chromosomal segments distinct ancestry. Disease statistics previously considered SNP (LD mapping) or admixture (mapping by admixture-LD), but not both. Here, we introduce new...
Although recent studies have attempted to dispel the confusion that exists in regard definition, analysis and interpretation of interaction genetics, there still remain aspects are poorly understood by non-statisticians. After a brief discussion definition gene-gene interaction, main part this study addresses fundamental meaning statistical its relationship measurement scale, disproportionate sample sizes cells two-way table gametic phase disequilibrium.
Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there strong clinical epidemiologic evidence supporting the importance of genetic factors in influencing obstructive apnea, its basis still largely unknown. Prior studies focused on traits defined using apnea-hypopnea index, which contains limited information potentially important genetically determined physiologic factors, such as propensity...
Hypertension is a leading cause of global disease, mortality, and disability. While individuals African descent suffer disproportionate burden hypertension its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure people ancestry, we performed both single multiple-trait genome-wide association analyses. We analyzed 21 studies comprised 31,968 validated our results with additional 54,395 from multi-ethnic These analyses...
Sesame is an important high-quality oil seed crop. The sesame genome was de novo sequenced and assembled in 2014 (version 1.0); however, the number of anchored pseudomolecules higher than chromosome (2n = 2x 26) due to lack a high-density genetic map with 13 linkage groups. We resequenced permanent population consisting 430 recombinant inbred lines constructed improve assembly. successfully 327 scaffolds onto pseudomolecules. new assembly 2.0) included 97.5 % greater 150 kb size present...