Noah Zaitlen
A5058484067- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Amyotrophic Lateral Sclerosis Research
- Genetic Syndromes and Imprinting
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Neurogenetic and Muscular Disorders Research
- Molecular Biology Techniques and Applications
- CRISPR and Genetic Engineering
- BRCA gene mutations in cancer
- Ethics in Clinical Research
- T-cell and B-cell Immunology
- Genomics and Chromatin Dynamics
- Evolutionary Algorithms and Applications
University of California, Los Angeles
2009-2025
University of California, San Francisco
2015-2024
Columbia University
2024
UCLA Health
2019-2023
APLA Health
2023
Laboratoire d'Informatique de Paris-Nord
2022
University of Colorado Anschutz Medical Campus
2022
University of California System
2020-2021
UtopiaCompression (United States)
2021
Center for Human Genetics
2018-2020
Abstract Genomewide association mapping in model organisms such as inbred mouse strains is a promising approach for the identification of risk factors related to human diseases. However, genetic studies are confronted by problem complex population structure among strains. This induces inflated false positive rates, which cannot be corrected using standard approaches applied genomic control or structured association. Recent demonstrated that mixed models successfully correct relatedness maize...
Race and Genetic Ancestry in Medicine U.S. health inequities won’t be eliminated by abandoning the use of race ethnicity research clinical practice, since these variables capture key epi...
Important knowledge about the determinants of complex human phenotypes can be obtained from estimation heritability, fraction phenotypic variation in a population that is determined by genetic factors. Here, we make use extensive phenotype data Iceland, long-range phased genotypes, and population-wide genealogical database to examine heritability 11 quantitative 12 dichotomous sample 38,167 individuals. Most previous estimates are derived family-based approaches such as twin studies, which...
Variants of UNC13A, a critical gene for synapse function, increase the risk amyotrophic lateral sclerosis and frontotemporal dementia
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains incomplete. We profiled more than 1.2 million peripheral blood mononuclear cells (162 cases, 99 controls) multiplexed single-cell RNA sequencing (mux-seq). Cases exhibited elevated expression type 1 interferon-stimulated genes (ISGs) in monocytes, reduction naïve CD4
T lymphocyte activation by antigen conditions adaptive immune responses and immunopathologies, but we know little about its variation in humans genetic or environmental roots. We analyzed gene expression CD4(+) cells during unbiased helper 17 (T(H)17) from 348 healthy participants representing European, Asian, African ancestries. observed interindividual variability, most marked for cytokine transcripts, with clear biases on the basis of ancestry, following patterns more complex than simple...
Genomic imprinting is an important regulatory mechanism that silences one of the parental copies a gene. To systematically characterize this phenomenon, we analyze tissue specificity from allelic expression data in 1582 primary samples 178 individuals Genotype-Tissue Expression (GTEx) project. We 42 genes, including both novel and previously identified genes. Tissue widespread, gender-specific effects are revealed small number genes muscle with stronger males. IGF2 shows maternal brain...
Abstract Motivation: Imputation using external reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies and meta-analysis. Existing hidden Markov models (HMM)-based imputation approaches require individual-level genotypes. Here, we develop new method Gaussian from summary statistics, type of data that becoming available. Results: In simulations Genomes (1000G) data, this recovers 84% (54%) the effective sample size common...
Populations are often divided categorically into distinct racial/ethnic groups based on social rather than biological constructs. Genetic ancestry has been suggested as an alternative to this categorization. Herein, we typed over 450,000 CpG sites in whole blood of 573 individuals diverse Hispanic origin who also had high-density genotype data. We found that both self-identified ethnicity and genetically determined were each significantly associated with methylation levels at 916 194 CpGs,...
The observation of genetic correlations between disparate human traits has been interpreted as evidence widespread pleiotropy. Here, we introduce cross-trait assortative mating (xAM) an alternative explanation. We observe that xAM affects many phenotypes and phenotypic cross-mate correlation estimates are strongly associated with ( R 2 = 74%). demonstrate existing plausibly accounts for substantial fractions previously reported some pairs psychiatric disorders congruent alone. Finally,...