Scott Huntsman
A5084533856- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Genetic factors in colorectal cancer
- Forensic and Genetic Research
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Multiple Myeloma Research and Treatments
- Birth, Development, and Health
- Genetic diversity and population structure
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Genetic Mapping and Diversity in Plants and Animals
University of California, San Francisco
2016-2025
UCSF Helen Diller Family Comprehensive Cancer Center
2010-2025
City College of San Francisco
2019
San Francisco VA Medical Center
2017
The Coordinating Center
2017
New Mexico State University
2017
University of California, Berkeley
2015
Cancer Prevention Institute of California
2009-2013
Stanford University
2013
Cancer Institute (WIA)
2013
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic within over 1000 individuals representing 20 indigenous 11 mestizo populations. found striking genetic stratification among populations at varying degrees geographic isolation. Some groups were as differentiated Europeans are East Asians. Pre-Columbian substructure is recapitulated in the ancestry admixed across...
The insulin/IGF1 signaling pathways affect lifespan in several model organisms, including worms, flies and mice. To investigate whether common genetic variation this pathway influences humans, we genotyped 291 variants 30 genes encoding proteins the a cohort of elderly Caucasian women selected from Study Osteoporotic Fractures (SOF). included 293 long-lived cases (lifespan > or = 92 years (y), mean +/- standard deviation (SD) 95.3 2.2y) 603 average-lifespan controls < 79y, 75.7 2.6y)....
Acute lymphoblastic leukemia (ALL) is the most common cancer in children and incidence of ALL varies by ethnicity. Although accumulating evidence indicates inherited predisposition to ALL, genetic basis susceptibility diverse ancestry has not been comprehensively examined.We performed a multiethnic genome-wide association study 1605 with 6661 control subjects after adjusting for population structure, validation three replication series 845 case 4316 subjects. Association was tested two-sided...
Populations are often divided categorically into distinct racial/ethnic groups based on social rather than biological constructs. Genetic ancestry has been suggested as an alternative to this categorization. Herein, we typed over 450,000 CpG sites in whole blood of 573 individuals diverse Hispanic origin who also had high-density genotype data. We found that both self-identified ethnicity and genetically determined were each significantly associated with methylation levels at 916 194 CpGs,...
Abstract Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting pattern levels of expression these genes important for deeper understanding SARS-CoV-2 tropism pathogenesis. Here we explore role genetics co-expression networks in regulating airway, through analysis nasal airway transcriptome data from 695 children. We identify quantitative trait loci both , vary frequency...
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from 2,733 African Americans, Puerto Ricans Mexican Americans. found that heritability significantly increased with greater proportions ancestry decreased higher Indigenous American ancestry, reflecting relationship between heterozygosity variance. Among heritable protein-coding genes, prevalence ancestry-specific quantitative trait loci (anc-eQTLs)...
The population of Argentina is the result intermixing between several groups, including Indigenous American, European and African populations. Despite commonly held idea that mostly origin, multiple studies have shown this process admixture had an impact in entire Argentine population. In present study we characterized distribution ancestry among individuals from different regions evaluated level discrepancy self-reported grandparental origin genetic estimates. A set 99 autosomal informative...
Abstract The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of in and identify significant risk variant, located 5′ the Estrogen Receptor 1 gene ( ESR1 ; 6q25 region). minor allele for this variant is strongly protective (rs140068132: odds ratio (OR) 0.60, 95% confidence interval (CI) 0.53–0.67, P =9 × 10 −18 ), originates from Indigenous Americans uncorrelated with previously reported variants at...
Naturally blond hair is rare in humans and found almost exclusively Europe Oceania. Here, we identify an arginine-to-cysteine change at a highly conserved residue tyrosinase-related protein 1 (TYRP1) as major determinant of Solomon Islanders. This missense mutation predicted to affect catalytic activity TYRP1 causes through recessive mode inheritance. The frequency 26% the Islands, absent outside Oceania, represents strong common genetic effect on complex human phenotype, highlights...
Rationale: Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response.Objectives: To identify genetic variants important response (BDR) racially diverse children.Methods: We performed first whole-genome sequencing pharmacogenetics study from 1,441 children with tails of BDR distribution to association BDR.Measurements and Main Results: identified population-specific shared associated BDR,...
Genetic data are known to harbor information about human demographics, and genotyping commonly used for capturing ancestry by leveraging genome-wide differences between populations. In contrast, it is not clear what extent population structure captured whole-genome DNA methylation data. We demonstrate, using three large-cohort 450K array sets, that signal mirrored in can be further isolated more effectively the correlation of CpGs with cis-located SNPs. Based on these insights, we propose a...
Abstract Purpose: Genetic differences in immunity may contribute to toxicity and outcomes with immune checkpoint inhibitor (CPI) therapy, but these relationships are poorly understood. We examined the genetics of thyroid immune-related adverse events (irAE). Experimental Design: In patients non–small cell lung cancer (NSCLC) treated CPIs at Memorial Sloan Kettering (MSK) Vanderbilt University Medical Center (VUMC), we evaluated irAEs. typed germline DNA using genome-wide single-nucleotide...
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal epithelium 681 children, with UK Biobank data. Our analysis identified 95 genes, 58 which were not analyses using other asthma-relevant tissues. Among these genes MUC5AC, an mucin, and FOXA3, transcriptional driver mucus metaplasia. Muco-ciliary epithelial cultures genotyped donors revealed that MUC5AC risk variant increases protein...
Abstract U.S. Latinas have a lower incidence of breast cancer compared with non-Latina White women. This difference is partially explained by differences in the prevalence known risk factors. Genetic factors may also contribute to this incidence. are an admixed population most their genetic ancestry from Europeans and Indigenous Americans. We used markers estimate Latina cases controls assessed association ancestry, adjusting for reproductive other typed set 106 informative 440 women 597 San...