A5078039285- Cell Adhesion Molecules Research
- Respiratory viral infections research
- Developmental Biology and Gene Regulation
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- Angiogenesis and VEGF in Cancer
- DNA and Nucleic Acid Chemistry
- Neurobiology and Insect Physiology Research
- Hippo pathway signaling and YAP/TAZ
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- TGF-β signaling in diseases
- DNA and Biological Computing
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Bacteriophages and microbial interactions
- Genomics and Chromatin Dynamics
- Cystic Fibrosis Research Advances
- Occupational and environmental lung diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA and protein synthesis mechanisms
- Animal Behavior and Reproduction
- Plant Molecular Biology Research
University of Colorado Denver
2020-2021
National Jewish Health
2020-2021
Johns Hopkins University
2016-2019
Boise State University
2014-2016
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells. We reasoned that differences in or gene expression sputum cells among patients with asthma may identify subgroups at risk for COVID-19 morbidity.
Abstract Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting pattern levels of expression these genes important for deeper understanding SARS-CoV-2 tropism pathogenesis. Here we explore role genetics co-expression networks in regulating airway, through analysis nasal airway transcriptome data from 695 children. We identify quantitative trait loci both , vary frequency...
Abstract Coronavirus disease 2019 (COVID-19) outcomes vary from asymptomatic infection to death. This disparity may reflect different airway levels of the SARS-CoV-2 receptor, ACE2, and spike protein activator, TMPRSS2. Here we explore role genetics co-expression networks in regulating these genes airway, through analysis nasal transcriptome data 695 children. We identify expression quantitative trait loci (eQTL) for both ACE2 TMPRSS2 , that frequency across world populations. Importantly,...
Each individual perceives the world in a unique way, but little is known about genetic basis of variation sensory perception. In fly eye, random mosaic color-detecting R7 photoreceptor subtypes determined by stochastic on/off expression transcription factor Spineless (Ss). genome-wide association study, we identified naturally occurring insertion regulatory DNA element ss that lowers ratio SsON to SsOFF cells. This change fates shifts innate color preference flies from green blue. The...
The Hippo pathway is crucial for not only normal growth and apoptosis but also cell fate specification during development. What controls activity incompletely understood. In this article, we identify the insulator protein BEAF-32 as a regulator of in Drosophila photoreceptor differentiation. Though morphologically uniform, fly eye composed two subtypes R8 neurons defined by expression light-detecting Rhodopsin proteins. one subtype, active signaling induces 6 (Rh6) represses 5 (Rh5), whereas...
The extracellular Matrix (ECM) has recently been implicated with the regulation of angiogenesis via manipulation Notch signaling system however molecular basis for this not explored. We previously showed that ECM protein microfibril‐associated glycoprotein 2 (MAGP2), suppresses in endothelial cells but promotes non‐endothelial cells. goal work was to dissect mechanism by which MAGP2 manipulates signaling. found control dependent on specific receptor‐ligand expression patterns. Interestingly...
<ns4:p>The rapid rise of high-throughput, data intensive experimental techniques has thrust many biologists into the role analyst – a feel ill equipped to fill. Novices often struggle find resources and expertise they need analyze their results in wet-lab environment. To fill this need, we developed an educational resource as part National Center for Biotechnology Information (NCBI) hackathon. Using RNA-seq model, our tutorial guides new users through steps analysis, while placing emphasis...
Abstract The position weight matrix (PWM) has long been a useful tool for describing variation in the composition of regions DNA such as transcription factor (TF) binding sites. It is difficult, however, to relate sequence-based representation motif biological features interaction TF with its site. Here we present an alternative strategy representing motifs – called Structural Motif (StruM) that can easily represent different sets structural features. are inferred from dinucleotide...
RATIONALE Nearly 3 million United States military service members have deployed to Southwest Asia since 2001, and returning personnel increased rates of new-onset respiratory symptoms asthma.Frequent dust storms expose deployers unique airborne silicate-containing particulate matter (PM).We hypothesized that airway epithelial dysfunction mediated by this PM exposure contributes development deployment-related lung disease.To test hypothesis, we investigated the transcriptome-wide response...