A5005205857- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Atomic and Subatomic Physics Research
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Delphi Technique in Research
- Advanced NMR Techniques and Applications
- Quantum, superfluid, helium dynamics
- Studies on Chitinases and Chitosanases
- Invertebrate Immune Response Mechanisms
- Urticaria and Related Conditions
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Antimicrobial Peptides and Activities
- Mast cells and histamine
- Respiratory Support and Mechanisms
- Protease and Inhibitor Mechanisms
University of Wisconsin–Madison
2016-2025
UW Health University Hospital
2011-2025
Pulmonary and Allergy Associates
2007-2022
Pulmonary and Critical Care Associates
1998-2022
National Jewish Health
2021
University of Colorado Denver
2021
Wisconsin Institutes for Discovery
2021
Hunter Medical Research Institute
2019
Brigham and Women's Hospital
2019
Harvard University
2019
Rationale: The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma.Objectives: To identify novel phenotypes using an unsupervised hierarchical cluster analysis.Methods: Reduction the initial 628 variables to 34 core was achieved by elimination redundant data transformation categorical into ranked ordinal composite variables....
Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy applied to the airway wall decrease smooth muscle.To evaluate effectiveness and safety of BT versus sham subjects with severe asthma who remain symptomatic despite treatment high-dose inhaled corticosteroids long-acting beta(2)-agonists.A total 288 adult (Intent-to-Treat [ITT]) randomized or control underwent three bronchoscopy procedures. Primary outcome was difference Asthma Quality Life...
IgE plays an important role in allergic asthma. We hypothesized that reducing the airway mucosa would reduce inflammation. Forty-five patients with mild to moderate persistent asthma sputum eosinophilia of 2% or more were treated humanized monoclonal antibody against (omalizumab) (n = 22) placebo 23) for 16 weeks. Outcomes included inflammatory cells induced and bronchial biopsies, methacholine responsiveness. Treatment omalizumab resulted marked reduction serum a IgE+ mucosa. The mean...
The evolutionarily conserved 18-glycosyl-hydrolase family contains true chitinases and chitinase-like proteins that lack enzymatic activity. Acidic mammalian chitinase has recently been associated with animal models of asthma. related protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] 3-like 1), can be readily measured in the serum. However, its relationship to asthma not evaluated.We quantified serum levels three cohorts patients asthma--one recruited from patient...
This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available relevant European Respiratory Society/American Thoracic Society Task Force's questions. The was appraised using GRADE (Grading Recommendations, Assessment, Development and Evaluation) approach results summarised in profiles. syntheses discussed formulated by a multidisciplinary Force asthma experts, who made...
Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled are needed.
BACKGROUND. The link between mucus plugs and airflow obstruction has not been established in chronic severe asthma, the role of eosinophils their products plug formation is unknown.
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells. We reasoned that differences in or gene expression sputum cells among patients with asthma may identify subgroups at risk for COVID-19 morbidity.
Reducing asthma exacerbation frequency is an important criterion for approval of therapies, but the clinical features exacerbation-prone (EPA) remain incompletely defined.To describe clinical, physiologic, inflammatory, and comorbidity factors associated with EPA.Baseline data from NHLBI Severe Asthma Research Program (SARP)-3 were analyzed. An was defined as a burst systemic corticosteroids lasting 3 days or more. Patients classified by their number exacerbations in past year: none, few...
Five to ten percent of asthma cases are poorly controlled chronically and refractory treatment, these severe account for disproportionate asthma-associated morbidity, mortality, health care utilization. While persons with tend have more airway obstruction, it is not known whether they represent the tail a unimodal population, or phenotype. We hypothesized that has characteristic physiology we evaluated spirometry, lung volumes, reversibility during stable interval in 287 382 nonsevere...
Rationale: Exhaled nitric oxide (FeNO) is a biomarker of airway inflammation in mild to moderate asthma. However, whether FeNO levels are informative regarding patients with severe asthma, who refractory conventional treatment, unknown. Here, we hypothesized that classification asthma based on as defined by would identify more reactive, at-risk phenotype.Methods: and major features including inflammation, airflow limitation, hyperinflation, hyperresponsiveness, atopy, were determined 446...
The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals severe asthma. SARP collaboration led to a rapid recruitment of subjects efficient sharing samples among participating sites conduct independent mechanistic investigations Enrolled underwent detailed clinical, physiologic, genomic, radiological evaluations. In addition, investigators developed safe procedures for...
Neutrophil cytoplasts promote T H 17 inflammation.
Mast cells are present in the airways of patients who have severe asthma despite glucocorticoid treatment; these associated with disease characteristics including poor quality life and inadequate control. Stem cell factor its receptor, KIT, central to mast-cell homeostasis. We conducted a proof-of-principle trial evaluate effect imatinib, KIT inhibitor, on airway hyperresponsiveness, physiological marker asthma, as well numbers activation asthma.We randomized, double-blind,...
Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans the Severe Asthma Research Program (SARP)-3 showed a high plug phenotype.
Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) an arachidonic acid-derived mediator that serves as agonist for resolution of inflammation.Airway levels LXA(4), well the expression lipoxin biosynthetic genes and receptors, asthma.Samples bronchoalveolar lavage fluid were obtained from subjects LXA(4) related eicosanoids measured. Expression was determined whole blood, cells, endobronchial biopsies by quantitative...
Although rhinovirus (RV) infections can cause asthma exacerbations and alter lower airway inflammation physiology, it is unclear how important bronchial infection to these processes. To study the kinetics, location, frequency of RV appearance in tissues during an acute infection, immunohistochemistry quantitative polymerase chain reaction analysis were used analyze presence virus cells from nasal lavage, sputum, bronchoalveolar brushings, biopsy specimens 19 subjects with experimental...
Persistent asthma is associated with airway inflammation, tissue damage, and deposition of extracellular matrix (ECM) proteins, which may be mediated, in part, through release metalloproteinases (MMPs) inhibitor metalloproteinase-1 (TIMP-1). To investigate the role allergen induction MMP-9 TIMP-1, bronchoscopy segmental bronchoprovocation (SBP) saline (SAL) antigen (AG) were performed 17 allergic subjects. Bronchoalveolar lavage (BAL) was done 5 min 48 h after challenge concentrations TIMP-1...