A5060782005- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Eosinophilic Esophagitis
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Voice and Speech Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Contact Dermatitis and Allergies
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Statistical Methods in Clinical Trials
- Gastroesophageal reflux and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
- Nail Diseases and Treatments
- Receptor Mechanisms and Signaling
University of Pittsburgh Medical Center
2016-2025
University of Pittsburgh
2015-2024
Children's Hospital of Pittsburgh
2008-2024
Pulmonary and Allergy Associates
2017-2022
UPMC Montefiore
2009-2021
Brigham and Women's Hospital
2019
Pennsylvania State University
2006
Penn State Milton S. Hershey Medical Center
2006
Reducing asthma exacerbation frequency is an important criterion for approval of therapies, but the clinical features exacerbation-prone (EPA) remain incompletely defined.To describe clinical, physiologic, inflammatory, and comorbidity factors associated with EPA.Baseline data from NHLBI Severe Asthma Research Program (SARP)-3 were analyzed. An was defined as a burst systemic corticosteroids lasting 3 days or more. Patients classified by their number exacerbations in past year: none, few...
Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in pathogenesis, but it unknown how their phenotype, location, and activation relate to severity.
Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation IL-1β secretion from monocytes cause airway epithelial cell injury, but the role of eDNA, NETs, asthma is uncertain.
We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated 50% of patients with severe asthma, despite high dose corticosteroid (CS) treatment. hypothesized a downstream target IFN-γ, CXCL10, which recruits Th1 cells via cognate receptor CXCR3, is an important contributor to Th1high asthma and CS unresponsiveness. show CXCL10 mRNA closely associated IFNG BAL asthmatics also mice subjected model, both context high-dose The inability...
Phenotypic distinctions between severe asthma (SA) and nonsevere (NONSA) may be confounded by differential adherence or incorrect use of corticosteroids.
Severe asthma is characterized by decreased NK cell cytotoxicity, and corticosteroids further disable function.
Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, females. The surge of sex hormones with might explain this gender switch. To examine the effects on lung function and symptoms puberty, Tanner stage was assessed 187 children 6–18 years age (59% severe) enrolled NIH/NHLBI Severe Asthma Research Program (SARP). circulating (n = 68; testosterone, dehydroepiandrosterone sulfate (DHEA-S), estrogen, progesterone) 4 week symptom control (ACQ6) cross-section...
The role of obesity-associated insulin resistance (IR) in airflow limitation asthma is uncertain.
The relative utility of eosinophil peroxidase (EPX) and blood sputum counts as disease biomarkers in asthma is uncertain.
Vocal cord dysfunction (VCD) is frequently misdiagnosed and mistreated as asthma, which leads to morbidity secondary unnecessary medication use increased health care utilization.We identified discriminating symptoms triggers, analyzed the costs, morbidity, burden associated with misdiagnosis of VCD asthma. We sought determine if current measures asthma control contributed these findings. evaluated a simple set breathing exercises would be an effective low-cost treatment option for those...
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Abstract Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute lung pathophysiology. We also test the therapeutic potential of nitro-oleic (NO 2 -OA), a regulator metabolic and inflammatory signaling pathways, mitigate allergen obesity-induced function decline murine model acids were measured plasma healthy subjects asthma serum tissue mice without allergic airway disease (AAD). Lung function,...