A5010966426- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Endometrial and Cervical Cancer Treatments
- Hormonal Regulation and Hypertension
- Respiratory Support and Mechanisms
- Uterine Myomas and Treatments
- Statistical Methods in Clinical Trials
- Pelvic floor disorders treatments
- Neonatal Respiratory Health Research
- Endometriosis Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Respiratory and Cough-Related Research
- Gynecological conditions and treatments
- Prostate Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Adrenal Hormones and Disorders
- Pharmacological Effects and Assays
- Dental Radiography and Imaging
- Advanced X-ray and CT Imaging
- Cervical Cancer and HPV Research
- Food Allergy and Anaphylaxis Research
- Silk-based biomaterials and applications
- Optimal Experimental Design Methods
- Gestational Trophoblastic Disease Studies
Université Laval
1999-2025
Hôtel-Dieu de Québec
2009-2025
National Heart Lung and Blood Institute
2004-2023
National Institutes of Health
2001-2022
Centre hospitalier universitaire de Québec
2013-2015
Montreal General Hospital
2012
McGill University
2012
Yale University
2004
UW Health University Hospital
2004
Wilfrid Laurier University
1999
Because of the widespread use cytologic screening programs in industrialized nations, cervical carcinoma is being diagnosed younger patients and at an earlier stage. The traditional therapy for early-stage disease radical hysterectomy with pelvic lymphadenectomy, which leads to infertility. In past 20 years, fertility-sparing therapies, such as conization trachelectomy, have emerged show good oncologic obstetric outcomes. selection criteria vaginal trachelectomy include stages IA2 IB1, a...
Significance Although resistance to glucocorticoids is a major clinical problem, the underlying mechanisms are unknown. It known that glucocorticoid use can suppress adrenal androgen production. In population studies, animal models, and cell culture experiments, androgens associated with several benefits in asthma, but neither glucocorticoid-resistant asthma nor genetic determinants of responsiveness have been studied humans. A missense-encoding variant HSD3B1 regulate conversion from...
Section:ChooseTop of pageAbstract <<PRIORITY 1: INNATE IMMUNI...PRIORITY 2: MECHANISMS AN...PRIORITY 3: OF...PRIORITY 4: GENETICS/GENE...INITIATIVE 5: INTERVENTIO...INITIATIVE 6: VASCULAR BA...ReferencesCITING ARTICLES
The Precision Interventions for Severe and/or Exacerbation-prone Asthma (PrecISE) study is an adaptive platform trial designed to investigate novel interventions severe asthma. conducted under a master protocol and utilizes crossover design with each participant receiving up five at least one placebo. Treatment assignments are based on the patients' biomarker profiles precision health methods incorporated into interim final analyses. We describe key elements of PrecISE including multistage...
INTRODUCTION The National Heart, Lung and Blood Institute (NHLBI) convened the Heart Tolerance Working Group on December 4, 2000 in Bethesda, MD to determine whether data from animal studies are sufficient justify initiating tolerance induction protocols human heart or lung transplant patients. comprised experts basic clinical aspects of transplantation, transplantation immunology, bioethics, assisted by staff Institutes Health (NIH), Food Drug Administration (FDA), Department Human Services...
Purpose To determine the optimal single shot fast spin echo (SSFSE) technique by varying interval between image acquisitions for cine MRI of uterine peristalsis. Materials and Methods was performed in 13 premenopausal women (4 normal 9 with benign pelvic pathology) various phases their menstrual cycle. Midsagittal uterus scanned using a multiphasic SSFSE at 2-, 3-, 4-s intervals over 2 min. Three readers independently randomly evaluated peristaltic frequency/2 min, longitudinal direction...
Since their discovery ~70 years ago, glucocorticoids (GC) have been widely used to elicit a systemic anti-inflammatory response, and currently play major role in the treatment of asthma other inflammatory diseases (1). However, unresponsiveness GC some individuals is limitation asthma, mechanisms underlying this clinical entity are not fully elucidated Indeed, severe generally defined as that remains symptomatic despite high-dose inhaled and/or therapy. GCs inhibit production adrenal...
Abstract Aims To investigate the intra‐ and inter‐rater reliability of two‐dimensional (2D) transperineal ultrasound imaging (USI) measures bladder wall thickness (BWT), urethral length (UL), parameters related to levator plate (LP) transient changes in LP during pelvic floor muscle (PFM) contraction, on Valsalva women who received radiation therapy (RT) for treatment cancer. Methods Twenty with a history RT cancer were assessed independently by two raters same day. Five outcomes...
21-year-old National Heart Institute to become the and Lung (NHLI) consolidate pulmonary research from across NIH under one office.Over last 50 years, this office, which became Division of Diseases (DLD) in July 1972, has grown a budget $5 million $734 2018, released over 350 initiatives, expanded now fund about 1,800 grants contracts each year.Simultaneously, attendance at annual American Thoracic Society meetings soared approximately 2,000 1969 16,000 2017.Many partners stakeholders have...