A5042613825- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Breastfeeding Practices and Influences
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Congenital Diaphragmatic Hernia Studies
- Sinusitis and nasal conditions
- Pregnancy and Medication Impact
- Noise Effects and Management
- Climate Change and Health Impacts
- Infant Nutrition and Health
- Tracheal and airway disorders
- Reproductive System and Pregnancy
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Infant Health and Development
- Occupational exposure and asthma
University of Arizona
2015-2025
Dermatology Research Center
2018-2024
Arizona Science Center
2006-2015
British Association for Immediate Care Scotland
2015
BASilar artery International Cooperation Study
2015
Arizona Research Center
2013
University of Colorado Health
2005
National Jewish Health
2005
University of Colorado Denver
2005
The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based the occurrence lower illnesses before age 3 yr active wheeze at 6 yr: never wheezers (n = 425), transient 164), persistent 113), late-onset 124).We sought to determine prognosis for these phenotypes, with reference lung symptoms, adolescence.Current...
The relationships of asthma and allergic rhinitis with individual immediate skin test responses were examined for preferential associations changes age in children raised a semiarid environment. Prevalence physician-diagnosed was 9.8% at 6 (n = 948) 15.5% 11 895). Immediate to Bermuda grass the most prevalent among control subjects, whereas mold, Altenaria alternata, asthmatics. Skin crude house dust, Dermatophagoides farinae, cat had low prevalences all groups. By logistic regression,...
Rationale: Low maximally attained lung function increases the risk of chronic obstructive pulmonary disease irrespective subsequent rate decline.Objectives: We aimed to determine if there were individuals with a distinct, persistently low trajectory in CRS (Tucson Children’s Respiratory Study).Methods: The CRS, an ongoing birth cohort study, enrolled 1,246 participants between 1980 and 1984. Latent class linear mixed effects modeling ratio FEV1 FVC was used identify distinct trajectories...
Diminished lung function and increased prevalence of asthma have been reported in children with a history early lower respiratory illnesses (LRIs), including pneumonia. Whether these associations persist up to adulthood has not established.As part the prospective Tucson Children's Respiratory Study, LRIs during first 3 years life were ascertained by pediatricians. Spirometry was performed at ages 11, 16, 22, 26 years. The occurrence asthma/wheeze previous year 13, 18, 24, 26, 29 Longitudinal...
Background: Italy has one of the world's oldest populations, and suffered highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), in particular hypertension, are at higher risk hospitalization for COVID-19. Whether hypertension medications may increase older COVID 19 inpatients is currently unknown. Methods: Data 5,625 COVID-19 were manually extracted medical charts 61 hospitals across Italy. From initial patients, 3,179...
Genetic factors are known to strongly influence susceptibility allergic inflammation. The Th2 cytokine IL-13 is a central mediator of allergy and asthma, common single-nucleotide polymorphisms in IL13 associated with phenotypes several ethnically diverse populations. In particular, IL13+2044G→A expected result the nonconservative replacement arginine 130 (R130) glutamine (Q). We examined impact on functional properties by directly comparing activity WT R130Q primary human cells involved...
Genetic factors are known to strongly influence susceptibility allergic inflammation. The Th2 cytokine IL-13 is a central mediator of allergy and asthma, common single-nucleotide polymorphisms in IL13 associated with phenotypes several ethnically diverse populations. In particular, IL13+2044G→A expected result the nonconservative replacement arginine 130 (R130) glutamine (Q). We examined impact on functional properties by directly comparing activity WT R130Q primary human cells involved...
Cord serum IgE levels are predictive of subsequent atopic diseases early in life. Lower respiratory illnesses (LRI) have often been included with infancy but not examined as a separate entity for relation to cord levels. Among 767 healthy newborns Tucson, Arizona studied longitudinally, were directly related the incidence eczema. In contrast, LRI only failed show direct relationship actually decreased increasing from 34.8% lowest group 22.2% highest (> 1.0 IU/ml IgE; p trend chi-square <...
IL-13 is a central mediator of allergic inflammation. The single nucleotide polymorphism IL13-1112C>T (rs1800925) associated with phenotypes in ethnically distinct populations, but the underlying mechanism(s) remain unknown. Using vivo, vitro, and silico analysis, we show that IL13-1112T allele enhanced IL13 promoter activity primary human murine CD4(+) Th2 lymphocytes. Increased expression cells was creation Yin-Yang 1 binding site overlapped STAT motif involved negative regulation...
Regulation of human immune cell cytokine production in vivo is not well understood due part to limitations on imposing experimental conditions. We proposed that life-imposed conditions (pregnancy, birth, age, gender), combined with large sample size, repeat sampling, and family-based recruitment would serve reveal peripheral blood cell-derived patterns reflective regulation regarding Th1/Th2 balance familial correlation. Mononuclear cells were obtained from 483 trios the Tucson Infant Immune...
<h3>Background</h3> Cross-sectional reports have suggested that, among active smokers, previous exposure to parental smoking may increase susceptibility development of chronic obstructive pulmonary disease. We assessed prospectively whether enhances the effects on early deficits lung function in young adults. <h3>Methods</h3> used data from prospective birth cohort, Tucson Children9s Respiratory Study. Maternal and paternal was via questionnaires completed by parents at time participant9s...
Rationale: CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one most abundant proteins in normal airway secretions and has been described as serum biomarker for obstructive lung diseases.Objectives: To determine whether low marker pathology or implicated pathophysiology progressive damage these conditions.Methods: Using human data from birth cohort Tucson Children's Respiratory Study, we examined relation circulating levels with pulmonary function responses to...