A5010809550- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Allergic Rhinitis and Sensitization
- Climate Change and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical and Biological Ozone Research
- Pediatric health and respiratory diseases
- Noise Effects and Management
- Occupational exposure and asthma
- Inhalation and Respiratory Drug Delivery
- Air Quality Monitoring and Forecasting
- Respiratory and Cough-Related Research
- Glutathione Transferases and Polymorphisms
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Energy and Environment Impacts
- Genomics, phytochemicals, and oxidative stress
- Food Allergy and Anaphylaxis Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Human Health and Disease
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Respiratory Support and Mechanisms
University of North Carolina at Chapel Hill
2016-2025
Center for Environmental Health
2005-2025
Boston Children's Hospital
2024
Harvard University
2024
American Academy of Allergy, Asthma and Immunology
2023-2024
Ministry of Culture
2019-2021
National Sagamihara Hospital
2019-2021
Lung Institute
2015-2021
Délégation Provence et Corse
2016-2020
Clinical Research Center Kiel
2016-2020
We present our efforts toward enabling a wearable sensor system that allows for the correlation of individual environmental exposures with physiologic and subsequent adverse health responses. This will permit better understanding impact increased ozone levels other pollutants on chronic asthma conditions. discuss inefficiency existing commercial off-the-shelf components to achieve continuous monitoring system-level nano-enabled improving wearability power consumption. Our consists wristband,...
Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, has not been firmly established long-term increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COPD). This Workshop brought together experts on mechanistic, epidemiological, and clinical aspects to review current knowledge regarding whether a causal factor in development and/or COPD. Speakers presented recent evidence their respective areas expertise related new...
Allergic rhinitis affects the quality of life millions people worldwide. Air pollution not only causes morbidity, but nearly 3 million per year die from unhealthy indoor air exposure. Furthermore, allergic and interact. This report summarizes discussion an International Expert Consensus on management aggravated by pollution. The begins with a review outdoor pollutants followed epidemiologic evidence showing impact climate change upper airway rhinitis. Mechanisms, particularly oxidative...
Ozone may play a significant role in the exacerbation of airway disease asthmatics, either by priming mucosa such that cellular responses to allergen are enhanced or exerting an intrinsic effect on inflammation. Previous investigations nonasthmatic subjects revealed ozone induces both nasal and bronchial inflammation, suggesting be used as surrogate marker for this pollutant mucosal In study, exposure 0.4 ppm inflammation 11 allergic asthmatics sensitive Dermatophygoides farinae was...
Exposure to ozone causes a decrease in spirometric lung function and an increase airway inflammation healthy young adults at concentrations as low 0.08 ppm, close the National Ambient Air Quality Standard for ground level ozone.
Airway mucosal surfaces are potentially subjected to a variety of oxidant stresses. submucosal glands secrete compounds that may protect the airways from injury. Cholinergically induced nasal gland secretion has recently been found contain low molecular weight antioxidant. In this report, isolation and identification secretory antioxidant described. Concentrated, cholinergically human secretions were fractionated through 10-kDa sieve DEAE anion-exchange chromatography. Fractions containing...
We investigated whether markers of airway and systemic inflammation, as well heart rate variability (HRV) in asthmatics, change response to fluctuations ambient particulate matter (PM) the coarse [PM with aerodynamic diameter 2.5-10 microm (PM(2.5-10))] fine (PM(2.5)) size range.Twelve adult living within a 30-mile radius an atmospheric monitoring site Chapel Hill, North Carolina, were followed over 12-week period. Daily PM(2.5-10) PM(2.5) concentrations measured separately for each 24-hr...
Rationale: Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration increased partial osmotic pressure, in part caused abnormal purine nucleotide regulation of ion transport, contribute the pathogenesis CB.Objectives: We tested hypothesis that CB hyperconcentration, pressures, reduced clearance.Methods: measured subjects with as compared normal asymptomatic smoking control indices concentration...
Abstract Exposome research can improve the understanding of mechanistic connections between exposures and health to help mitigate adverse outcomes across life span. The exposomic approach provides a risk profile instead single predictors thus is particularly applicable allergic diseases asthma. Under PRACTALL collaboration European Academy Allergy Clinical Immunology ( EAACI ) American Allergy, Asthma, AAAAI ), we evaluated current concepts unmet needs on role exposome in
This article was originally published online on 27 April 2018