A5041034753- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Pediatric health and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Drug-Induced Adverse Reactions
- Diabetes and associated disorders
- RNA and protein synthesis mechanisms
- Contact Dermatitis and Allergies
- Pharmaceutical studies and practices
- Cytokine Signaling Pathways and Interactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Colorado Anschutz Medical Campus
1992-2025
American Academy of Allergy, Asthma and Immunology
2001-2024
University of Missouri–Kansas City
2013-2023
Children's Mercy Hospital
2012-2021
Mercy Hospital
2008-2020
Tufts University
1981-2018
Tufts Medical Center
1981-2018
National Institute of Allergy and Infectious Diseases
1978-2017
Medical University of Warsaw
2017
World Allergy Organization
2009-2015
Interleukin 1 (IL-1) is a protein with several biological activities regulating host defense and immune responses. We report here the isolation of human IL-1 cDNA. It encodes precursor polypeptide 269 amino acids (30,747 Mr). mRNA isolated by hybridization to this cDNA was translated in reticulocyte cell-free system, yielding immunoprecipitable IL-1. Furthermore, hybrid-selected injected into Xenopus laevis oocytes, which subsequently secreted biologically active The nucleotide sequence...
We have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of originally published paper, 2009", available at http://www.waojournal.org. Namely, these comprise: "Mechanisms sublingual immunotherapy;" "Clinical efficacy immunotherapy" - reporting all data controlled trials after 2009; "Safety with recently Grading System for adverse reactions; "Impact immunotherapy...
The hypereosinophilic syndrome is a group of diseases characterized by persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ involvement and no recognized secondary cause. Although most patients have response to corticosteroids, side effects are common can lead considerable morbidity.We conducted an international, randomized, double-blind, placebo-controlled trial evaluating the safety efficacy anti-interleukin-5 monoclonal antibody, mepolizumab, in...
Background Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% reaches 20–30% those with an first-degree relative. Intestinal microbiota may modulate immunologic inflammatory systemic responses and, thus, influence development sensitization allergy. Probiotics been reported to immune their supplementation has proposed as a preventive intervention.Objective The World Allergy Organization (WAO) convened guideline panel develop...
Abstract Hereditary Angioedema ( HAE ) is a rare and disabling disease. Early diagnosis appropriate therapy are essential. This update revision of the global guideline for provides up‐to‐date consensus recommendations management . In development this guideline, an international expert panel reviewed existing evidence developed 20 that were discussed, finalized consented during conference in June 2016 Vienna. The final version incorporates contributions board reviewers endorsing societies....
Routine immunization, one of the most effective public health interventions, has effectively reduced death and morbidity due to a variety infectious diseases. However, allergic reactions vaccines occur very rarely can be life threatening. Given large numbers administered worldwide, there is need for an international consensus regarding evaluation management vaccines.Following review literature, with active participation representatives from World Allergy Organization (WAO), European Academy...
Corticosteroids mediate a variety of immunological actions and are commonly utilized in the treatment wide range diseases. Unfortunately, therapy with this class medications is associated large proportion non-responders significant side effects. Inhaled corticosteroids most used asthma controller therapy. However, asthmatic response to also varies widely between individuals. We investigated genetic contribution variation inhaled corticosteroid asthma. The association longitudinal change lung...
Interleukin-10 (IL-10) and transforming growth factor beta (TGF- β ) are inhibitory for B T cells, IgE production, mast cell proliferation, they induce apoptosis in eosinophils. These cytokines therefore candidate genes which could contribute to the development of asthma or allergies. We investigated hypothesis that polymorphic nucleotides within IL-10 TGF- gene promoters would link expression allergies asthma. DNA taken from families with an asthmatic proband was examined base exchanges by...
Adherent human blood monocytes were stimulated with heat-killed Staphylococcus albus or Escherichia coli lipopolysaccharide in the presence of 35S-methionine-, [3H]leucine-, 14C-labeled amino acids. After incubation, interleukin 1 (IL 1) activity supernatant medium was purified over an anti-human IL immunoadsorbent followed by gel filtration and chromatofocusing. The purity assessed fluorography one- two-dimensional SDS-polyacrylamide electrophoresis. Isoelectric chromatofocusing low m.w....
Leukocytic pyrogen (LP) is a polypeptide product of activated mononuclear phagocytes that has been established as the endogenous mediator fever. Recent studies show LP may be identical to lymphocyte-activating factor (LAF or interleukin 1). In present experiments, chromatographic separations human indicate fractions produce fever in rabbits and enhance phytohemagglutinin- (PHA) induced murine thymocyte proliferation activity) also stimulate monocyte monolayers release prostaglandin E (PGE)....
A macrophage-dependent, antigen-specific murine T-cell proliferation assay was utilized to examine the role of soluble products and human adherent cells in activation T lymphocytes. Highly purified leukocytic pyrogen, supernates from both mononuclear phagocytes-macrophages stimulated immune proliferative response multideterminant antigens dinitrophenyl-ovalbumin keyhole limpet hemocyanin. The implications these studies relationship pyrogen lymphocyte-activating factor are discussed.
The role of factors released by monocytes (M phi) in the activation human B lymphocytes was examined studying effect an antiserum against leukocytic pyrogen (LP) on mitogen-stimulated cell proliferation and generation immunoglobulin-secreting cells (ISC) peripheral blood mononuclear (PBM). Antiserum LP obtained from rabbits immunized with LP-containing M phi supernatants. globulin fraction this inhibited pokeweed mitogen- (PWM) stimulated ISC a concentration-dependent manner, 50% inhibition...