A5021045413- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Ethics in Clinical Research
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical industry and healthcare
- Nitric Oxide and Endothelin Effects
- Health and Medical Research Impacts
- Neuropeptides and Animal Physiology
- Biomedical Ethics and Regulation
- Inflammatory mediators and NSAID effects
- Meta-analysis and systematic reviews
- Clinical practice guidelines implementation
- Pediatric health and respiratory diseases
- Receptor Mechanisms and Signaling
- Pharmaceutical studies and practices
- IL-33, ST2, and ILC Pathways
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Assays
- Academic Publishing and Open Access
Harvard University
2007-2023
Brigham and Women's Hospital
2010-2023
Harvard University Press
1999-2023
Woman's Hospital
2003-2021
United States National Library of Medicine
2005-2019
University of Oxford
2019
Public Library of Science
2019
World Health Organization - Pakistan
2019
Dana-Farber Cancer Institute
2018
Medical Research Institute of New Zealand
2005-2017
Asthma is a serious health problem throughout the world. During past two decades, many scientific advances have improved our understanding of asthma and ability to manage control it effectively. However, recommendations for care need be adapted local conditions, resources services. Since was formed in 1993, Global Initiative Asthma, network individuals, organisations public officials, has played leading role disseminating information about patients with based on process continuous review...
The analysis of subgroups is often used as a way to glean additional information from data sets. strengths and weaknesses this approach new Journal policies concerning the reporting subgroup analyses are discussed in article.
Nitric oxide synthase (NOS) produces nitric oxide, a mediator of potential importance in numerous physiologic and inflammatory processes the lung. We localized constitutive NOS (c-NOS) inducible (i-NOS) within lung tissue by immunoperoxidase labeling with specific antibodies or histochemical demonstration characteristic NADPH diaphorase activity NOS. analyzed human airway (n = 4) parenchyma 10) specimens obtained from uninvolved areas surgical tumor resections. also studied fetal samples 6)...
Human asthma is associated with airway infiltration by T helper 2 (T H 2) lymphocytes. We observed reduced expression of the 1 transcription factor, T-bet, in cells from airways patients compared that nonasthmatic patients, suggesting loss T-bet might be asthma. Mice a targeted deletion gene and severe combined immunodeficient mice receiving CD4 + knockout spontaneously demonstrated multiple physiological inflammatory features characteristic Thus, deficiency, absence allergen exposure,...
The pharmacologic activities of leukotrienes C-1 and D(LTC-1 LTD), constituents slow reacting substance anaphylaxis (SRS-A), were evaluated in vitro on airway contractile tissues vivo pulmonary mechanical function, mean systemic arterial pressure, cutaneous microcirculation. In both LTC-1 LTD potent selective peripheral agonists, being more active than histamine; furthermore, was airways at concentrations 1/100th those LTC-1. concentration-effect relationship for the profile antagonism by...
Recent discoveries suggesting essential bioactivities of nitric oxide (NO.) in the lung are difficult to reconcile with established pulmonary cytotoxicity this common air pollutant. These conflicting observations suggest that metabolic intermediaries may exist modulate bioactivity and toxicity NO.. We report S-nitrosothiols (RS-NO), predominantly adduct glutathione, present at nano- micromolar concentrations airways normal subjects their levels vary different human pathophysiologic states....
Histochemical activity and immunoreactivity of nitric oxide synthase (NOS, EC 1.14.13.39) have been recently demonstrated in human lung epithelium. However, the molecular nature NOS regulation function enzyme(s) airway is not known. A549 cells (human alveolar type II epithelium-like), BEAS 2B (transformed bronchial epithelial cells), primary cultures all exhibited constitutive that was calcium dependent inhibitable by inhibitor NG-monomethyl-L-arginine. Nitric production enhanced culture...
Inhaled β -adrenergic agonists are the most commonly used medications for treatment of asthma although there is evidence that regular use may produce adverse effects in some patients. Polymorphisms β2-adrenergic receptor ( β2-AR) can affect regulation receptor. Smaller studies examining such polymorphisms on response to -agonist therapy have produced inconsistent results. We examined whether at codon 16 β2-AR-16) and 27 β2-AR-27) β2-AR might versus as-needed albuterol by genotyping 190...
Slow reacting substance(s) of anaphylaxis (SRS-A) was isolated from both human (lung) and rat sources compared with three synthetic SRS-As known structure—leukotrienes (LTs) C-1, C-2, D. Reversed-phase liquid chromatography used as a final purification step means comparison biologically derived substances. Two major peaks SRS-A activity origin corresponded chromatographically LTC-1 LTD, respectively, had equivalent specific activities on the guinea pig ileum. With ileum, (units/pmol) for...
Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index airway obstruction in comparing the effects leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene was 600 9500 times more potent than on a molar basis producing equivalent decrement maximum volume. The response slow onset prolonged, reminiscent allergen challenge asthmatic allergic subjects.
Severe alpha-1-antitrypsin deficiency is the only proven genetic risk factor for chronic obstructive pulmonary disease (COPD). We have assembled a cohort of 44 probands with severe, early-onset COPD, who do not severe deficiency. A surprisingly high prevalence females (79.6%) was found. Assessment to relatives these COPD airflow obstruction and bronchitis performed determine whether significant familial aggregation independent deficiency, could be demonstrated. First- degree had...