A5101628367- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Respiratory viral infections research
- Obstructive Sleep Apnea Research
- Immune Cell Function and Interaction
- Gut microbiota and health
- Circadian rhythm and melatonin
- Respiratory Support and Mechanisms
- Microbial infections and disease research
- Pharmaceutical studies and practices
- Classical Antiquity Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive tract infections research
- Gastroesophageal reflux and treatments
- Tracheal and airway disorders
Philipps University of Marburg
2025
University of Colorado Denver
2014-2024
Denver Health Medical Center
2024
Health and Hospital Corporation
2024
Institut National de Santé Publique du Québec
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Centre for Life
2023
National Jewish Health
2013-2022
Jewish Hospital
1983-2020
L'Oréal (France)
2007-2017
The role of inflammation in the pathogenesis severe asthma chronically treated with high doses glucocorticoids is poorly understood. Despite this, treatment has been aimed at advancing anti- inflammatory and immunomodulator therapy. This study was designed to evaluate both presence type airway patients asthma. A prospective bronchoscopic evaluated 14 severe, high-dose oral glucocorticoid dependent asthmatics. Bronchoalveolar lavage fluid analyzed for cytology mediators. Endobronchial...
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As physiologic and autopsy evidence suggests that peripheral airways parenchyma are involved in asthma, we hypothesized significant alveolar tissue inflammation is present patients with stable, chronic asthma. Eleven nocturnal asthma (NA) 10 non-nocturnal (NNA) were studied. Each subject underwent two bronchoscopies proximal airway endobronchial distal transbronchial biopsy a random order at 4:00 P.M. A.M. Morphometric analysis was used to determine the number per volume (Nv) of inflammatory...
Inhaled β -adrenergic agonists are the most commonly used medications for treatment of asthma although there is evidence that regular use may produce adverse effects in some patients. Polymorphisms β2-adrenergic receptor ( β2-AR) can affect regulation receptor. Smaller studies examining such polymorphisms on response to -agonist therapy have produced inconsistent results. We examined whether at codon 16 β2-AR-16) and 27 β2-AR-27) β2-AR might versus as-needed albuterol by genotyping 190...
Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled are needed.
One-quarter to one-third of individuals with asthma smoke, which may affect response therapy and contribute poor control.To determine if the an inhaled corticosteroid or a leukotriene receptor antagonist is attenuated in who smoke.In multicenter, placebo-controlled, double-blind, double-dummy, crossover trial, 44 nonsmokers 39 light smokers mild were assigned randomly treatment twice daily beclomethasone once oral montelukast.Primary outcome was change prebronchodilator FEV(1) versus...
Nocturnal asthma represents a unique subset of patients with who experience worsening symptoms and airflow obstruction at night. The basis for this phenotype is not known, but beta 2-adrenergic receptors (beta 2AR) are known to downregulate overnight in nocturnal asthmatics normal subjects or nonnocturnal asthmatics. We have recently delineated three polymorphic loci within the coding block 2AR which alter amino acids positions 16, 27, 164 impart specific biochemical pharmacologic phenotypes...
Although guidelines recommend daily therapy for patients with mild persistent asthma, prescription patterns suggest that most such use these so-called controller therapies intermittently. In we evaluated the efficacy of intermittent short-course corticosteroid treatment guided by a symptom-based action plan alone or in addition to either inhaled budesonide oral zafirlukast over one-year period.In double-blind trial, 225 adults underwent randomization. The primary outcome was morning peak...
Rationale: The role of airway microbiome in corticosteroid response asthma is unknown.Objectives: To examine composition patients with corticosteroid-resistant (CR) and compare it corticosteroid-sensitive (CS) normal control subjects explore whether bacteria the airways may direct alterations cellular responses to corticosteroids.Methods: 16S rRNA gene sequencing was performed on bronchoalveolar lavage (BAL) samples 39 12 healthy subjects. In asthma, responsiveness characterized, BAL...
IMPORTANCEIn asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes.It not known if supplementing inhaled corticosteroids oral 3 improves outcomes in patients insufficiency.OBJECTIVE To evaluate supplementation would improve the clinical efficacy of symptomatic lower levels. DESIGN, SETTING, AND PARTICIPANTSThe VIDA (Vitamin Add-on Therapy Enhances Corticosteroid Responsiveness Asthma) randomized, double-blind, parallel, placebo-controlled trial studying adult...
ContextLong-acting β2-agonists are prescribed for patients with persistent asthma and sometimes used without inhaled corticosteroids (ICSs). No evidence exists, however, to support their use as monotherapy in adults asthma.ObjectiveTo examine the effectiveness of salmeterol xinafoate, a long-acting β2-agonist, replacement therapy whose is well controlled by low-dose triamcinolone acetonide, an ICS.Design SettingA 28-week, randomized, blinded, placebo-controlled, parallel group trial...
In steroid-resistant (SR) asthma, there is a lack of clinical responsiveness to oral prednisone. Previous studies indicate that this may be explained by the effect combination interleukin 2 (IL-2) and IL-4 on glucocorticoid receptor binding affinity. By contrast, steroid-sensitive (SS) asthmatics respond well glucocorticoids, accompanied decrease in numbers bronchoalveolar lavage (BAL) messenger RNA+ (mRNA+) cells expressing IL-5, an increase interferon gamma (IFN-gamma) transcripts. present...
Inhaled beta-agonists are the most commonly used treatment for asthma, but data suggest that regularly scheduled use of these agents may have deleterious effect on control asthma. We compared effects inhaled albuterol with those only as needed in patients mild chronic, stable asthma.In a multicenter, double-blind study, we randomly assigned 255 asthma to inhale either regular schedule (126 patients) or (129 patients). The were followed 16 weeks.The primary outcome indicator, peak expiratory...
Infection with Mycoplasma pneumoniae has been shown to exacerbate asthma in humans. However, the role of M. pathogenesis chronic not defined. Eighteen asthmatics chronic, stable and 11 nonasthmatic control subjects underwent evaluation upper lower airways serologic analysis determine presence pneumoniae, Chlamydia seven respiratory viruses through culture, enzyme-linked immunoassay (EIA) polymerase chain reaction (PCR). was detected by PCR 10 18 one (p = 0.02). In nine patients, organism...
Nocturnal asthma is a frequent problem, but the mechanism unclear. We investigated possibility that airways inflammation occurred during night. Bronchoalveolar lavage fluid was analyzed in asthmatic patients with (n = 7) and without nocturnal at 1600 0400 h. The group had an increase total leukocyte count (24.0 ± 7.0 to 41.1 9.9 × 104 cells/ml, p < 0.05), neutrophils (1.1 0.6 3.7 1.5 #x00D7; eosinophils(0.5 0.1 1.7 0.7 0.05) from Cellular components for non-nocturnal did not change. Between...
We conducted a double-blind, randomized, placebo-controlled study to evaluate the efficacy of telithromycin in patients with acute exacerbations asthma.A total 278 adults diagnosed asthma were enrolled within 24 hours after an exacerbation requiring short-term medical care. The randomly assigned receive 10 days oral treatment (at dose 800 mg daily) or placebo addition usual Primary end points change from baseline over period symptoms (as recorded by diary card) and peak expiratory flow...