A5037297396- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Esophagitis
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- IL-33, ST2, and ILC Pathways
- Pharmaceutical studies and practices
- Indoor Air Quality and Microbial Exposure
- Neonatal Respiratory Health Research
- Eosinophilic Disorders and Syndromes
- Sinusitis and nasal conditions
- Medical and Biological Ozone Research
- Extracellular vesicles in disease
- Delphi Technique in Research
- Respiratory Support and Mechanisms
- Occupational Health and Safety Research
- Drug-Induced Adverse Reactions
- Air Quality Monitoring and Forecasting
- Health Systems, Economic Evaluations, Quality of Life
- Occupational and environmental lung diseases
University of Pisa
2016-2025
Nuovo Ospedale di Prato
2021
Azienda Ospedaliera Universitaria Pisana
2012-2020
University of Ferrara
2019-2020
Ospedale Maggiore
2020
IRCCS Humanitas Research Hospital
2020
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2020
Nicolet Chartrand Knoll (Canada)
2019
Ospedale Cisanello
1999-2019
Ninewells Hospital
2018
Some patients with asthma have frequent exacerbations and persistent airflow obstruction despite treatment inhaled glucocorticoids long-acting beta-agonists (LABAs).
Treatment guidelines recommend the regular use of inhaled corticosteroids for patients with mild persistent asthma. We investigated whether symptom-driven a combination beclomethasone dipropionate and albuterol (also known as salbutamol) in single inhaler would be effective superior to as-needed albuterol.We conducted 6-month, double-blind, double-dummy, randomized, parallel-group trial. After 4-week run-in, asthma were randomly assigned receive one four treatments: placebo twice daily plus...
Transient increases in blood eosinophil counts have been observed dupilumab clinical trials.To assess and eosinophilia-related treatment-emergent adverse events (TEAEs) across 11 trials, comparing adult adolescent patients with asthma chronic rhinosinusitis nasal polyps (CRSwNP), atopic dermatitis, eosinophilic esophagitis.Eosinophil counts, rates of TEAEs or eosinophilia (>1,500 cells/μL), discontinuations, symptoms, efficacy CRSwNP are presented.Transient mean were dupilumab-treated (mean...
BackgroundAsthma is one of the most common non-communicable respiratory diseases, affecting about 6% general population. Severe asthma, even if afflicts a minority asthmatics, drives majority costs disease. The aim this study to create pharmacoeconomic model predict corticosteroid-related adverse events in severe asthmatics and applying it first published epidemiologic data from Asthma Network Italy (SANI) registry.MethodsThe analysis was conducted perspective Italian National Healthcare...
Many patients with asthma remain symptomatic despite treatment inhaled corticosteroids (ICS) or without long-acting β2-agonists (LABAs). Tiotropium add-on to ICS plus a LABA has been shown improve lung function and reduce exacerbation risk in asthma.To determine whether the efficacy of tiotropium therapy is dependent on patients' baseline characteristics.Two randomized, double-blind, parallel-group, twin trials (NCT00772538 NCT00776984) once-daily Respimat(®) 5 μg were performed parallel...
BackgroundTiotropium, a once-daily long-acting anticholinergic bronchodilator, has demonstrated efficacy in patients with asthma who were symptomatic despite treatment medium- to high-dose inhaled corticosteroids (ICS).ObjectiveThe objective of this study was evaluate the and safety tiotropium Respimat (5 μg or 2.5 μg), compared placebo Respimat, as add-on therapy low- medium-dose ICS for adults asthma.MethodsA phase III, double-blind, placebo-controlled trial conducted (NCT01316380). Adults...
Background: Benralizumab has been shown to restore good control of severe eosinophilic asthma (SEA). Robust data on benralizumab effectiveness over periods longer than 2 years are scarce. Methods: This retrospective multicentric study was conducted 108 Italian SEA patients treated with for up 36 months. Partial and complete clinical remission (CR) were assessed. Data analyzed descriptive statistics or using linear, logistic, negative binomial mixed-effect regression models. Results: At...
The burden of severe asthma on patients, especially those with concomitant chronic rhinosinusitis nasal polyps (CRSwNP), is substantial. Treatment intensification oral corticosteroids a common strategy for managing exacerbations; however, prolonged exposure to systemic associated multisystem toxicity. This study aimed quantify the association between corticosteroid use and annual asthma-related costs in patients or without CRSwNP. pharmacoeconomic analysis was based data from Severe Asthma...
The present study was designed to compare the fixed combination of beclomethasone and formoterol in a hydrofluoroalkane Modulite® (Chiesi Farmaceutici, Parma, Italy) pressurised metered-dose inhaler (pMDI), with budesonide administered via Turbuhaler® (AstraZeneca, Lund, Sweden) dry powder (DPI). This phase III, multinational, multicentre, double-blind, double-dummy, randomised, two-arm parallel groups, controlled design. After 2-week run-in period, 219 patients moderate-to-severe asthma...
Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much known about its relationship with other disease features. Aim. To compare airway inflammatory markers clinical and functional findings in subjects stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent cross-sectional evaluation, including microbiologic cell profile sputum, exhaled breath condensate malondialdehyde (EBC-MDA). severity...
Purpose: After adolescence, asthma is more frequent in females than males due to different hormonal, immunologic, and occupational/environmental factors.The higher prevalence severity of the disease have already been reported international registries.The aim this study was explore difference terms clinical, functional, biological characteristics between male female patients with severe a reallife, registry-based setting.Methods: Baseline data from Severe Asthma Network Italy registry were...
Abstract Cell-derived microparticles (MP) are membrane fragments shed by virtually all eukaryotic cells upon activation or during apoptosis that play a significant role in physiologically relevant processes, including coagulation and inflammation. We investigated whether MP derived from monocytes/macrophages have the potential to modulate human airway epithelial cell activation. Monocytes/macrophages were isolated buffy coats of blood donors Ficoll gradient centrifugation, followed overnight...