A5056342735- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Delphi Technique in Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
- Birth, Development, and Health
- Pulmonary Hypertension Research and Treatments
- Pregnancy and preeclampsia studies
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Chronic Disease Management Strategies
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Centro de Investigación Biomédica en Red
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Universitat de Barcelona
2016-2025
Fundació Clínic per a la Recerca Biomèdica
2015-2025
Centre for Biomedical Network Research on Rare Diseases
2016-2024
Instituto de Salud Carlos III
2017-2024
Hospital Clínic de Barcelona
2017-2023
Departament de Salut
2022-2023
Institute for Research in Biomedicine
2023
Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume 1 second (FEV1) over time. Yet it possible that a normal FEV1 could also lead COPD persons whose maximally attained less than population norms.We stratified participants three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and Lovelace Smokers Cohort) according lung function (FEV1 ≥80% or <80% of predicted value) at cohort inception...
On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine chronic airway diseases such as asthma and obstructive pulmonary disease. It is now clear that both are complex heterogeneous diseases, often overlap require individualised assessment treatment. This paper summarises the presentations discussions took place during seminar. Specifically, we need for new taxonomy of human role different players this scenario...
Abstract Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading fatal diseases. Senescent cells are main driver fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). Here, we report cellular senescence, multiple types in mice humans characterized by the accumulation iron. We show vascular hemolytic injuries efficient triggering iron accumulation, which turn cause senescence...
Abstract Background Some individuals never achieve normal peak FEV 1 in early adulthood. It is unknown if this due to airflow limitation and/or lung restriction. Methods To investigate this, we: (1) looked forward 19,791 participants the Dutch Lifelines general population cohort aged 25–35 years with 5‐year follow‐up; and (2) backwards 2032 Swedish BAMSE birth spirometry at 24 of age but also 16 8 years. Results In 8.5% had reduced years, 68% Preserved Ratio Impaired Spirometry (‘PRISm’) 32%...
Lung function during childhood is an important predictor of subsequent health and disease. Understanding patterns lung development airflow limitation through necessary to inform trajectories in relation chronic airway We aimed derive from (age 5-8 years) into early adulthood 20-26 using repeated spirometry data birth cohorts. In this study, we drew forced expiratory volume 1 s (FEV1) vital capacity (FVC) six population-based cohorts: the UK-based Avon Longitudinal Study Parents Children...
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused a combination of airways (bronchiolitis) and parenchymal destruction (emphysema), whose relative proportion varies from patient to patient.Objectives: To explore contrast the molecular pathogenesis emphysema bronchiolitis in COPD.Methods: We used network analysis lung transcriptomics (Affymetrix arrays) 70 former smokers with COPD compare differential expression gene coexpression...
Rationale: Treatment of chronic obstructive pulmonary disease (COPD) with inhaled corticosteroids (ICS) is controversial, because it can reduce the risk future exacerbations at expense increasing pneumonia.Objectives: To assess relationship between presence bronchial infection (CBI), reduced number circulating eosinophils, ICS treatment, and pneumonia in patients COPD.Methods: This was a post hoc long-term observational study an historical cohort 201 COPD (Global Initiative for Chronic...
Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. Objectives: To explore plasticity individual function states childhood. Methods: Prebronchodilator FEV1 z-scores determined at age 8, 16, and 24 years in Swedish population-based birth cohort BAMSE (Swedish abbreviation Child [Barn], Allergy, Milieu, Stockholm, Epidemiological study) (N = 3,069) were used. An unbiased, data-driven dependent mixture model was applied...
Abstract Background and objective Asthma chronic obstructive pulmonary disease (COPD) are two prevalent complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence relationship of TTs to diagnostic label severity established by attending physician in real‐world setting unknown. We assessed how presence/absence specific relate diagnosis ‘asthma’, ‘COPD’ or ‘asthma + COPD’. Methods The authors selected 30...
Some COVID-19 survivors present lung function abnormalities during follow-up, particularly reduced carbon monoxide diffusing capacity (DLCO). To investigate risk factors and underlying pathophysiology, we compared the clinical characteristics levels of circulating pulmonary epithelial endothelial markers in with normal or DLCO 6 months after discharge.
The treatable traits approach represents a strategy for patient management. It is based on the identification of characteristics susceptible to treatments or predictive treatment response in each individual patient. With objective accelerating progress research and clinical practice relating such approach, Portraits event was convened Barcelona, Spain, November 2022. Here, while reporting key concepts that emerged from discussions during meeting, we review current state art related chronic...