A5068474273- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Air Quality and Health Impacts
- Sarcoidosis and Beryllium Toxicity Research
- Neuroscience of respiration and sleep
- Occupational exposure and asthma
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Nitric Oxide and Endothelin Effects
- Pleural and Pulmonary Diseases
- Allergic Rhinitis and Sensitization
- Delphi Technique in Research
- Gastroesophageal reflux and treatments
- Indoor Air Quality and Microbial Exposure
- Advanced Chemical Sensor Technologies
- Noise Effects and Management
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
Prince of Wales Hospital
2015-2025
UNSW Sydney
2016-2025
Royal Brisbane and Women's Hospital
2020-2024
The University of Queensland
2024
Westmead Hospital
2022-2023
Westmead Institute
2022-2023
University of Uyo
2023
GlaxoSmithKline (United Kingdom)
2023
The University of Sydney
1996-2022
Queensland Health
2020
Nitric oxide (NO) is produced by a variety of cells within the respiratory tract, including inflammatory epithelial cells. NO has been detected in exhaled air normal human subjects, and its concentration raised asthmatic patients. To study whether arises from we administered synthase (NOS) inhibitor, NG-monomethyl-L-arginine (L-NMMA), inhalation (490 mg) double-blind randomized manner nine six subjects. Because may arise an inducible isoform that be inhibited glucocorticosteroids, also...
Rationale: The burden of chronic obstructive pulmonary disease (COPD) is increasing, yet there are limited data on early life risk factors.Objectives: To investigate the role childhood lung function in adult COPD phenotypes.Methods: Prebronchodilator spirometry was performed for a cohort 7-year-old Tasmanian children (n = 8,583) 1968 who were resurveyed at 45 years, and selected subsample 1,389) underwent prebronchodilator post-bronchodilator spirometry. For this analysis, spirometrically...
Rationale: The contribution by asthma to the development of fixed airflow obstruction (AO) and nature its effect combined with active smoking atopy remain unclear.Objectives: To investigate prevalence relative influence lifetime asthma, smoking, on AO in middle age.Methods: population-based Tasmanian Longitudinal Health Study cohort born 1961 (n = 8,583) studied prebronchodilator spirometry 1968 was retraced 7,312) resurveyed 5,729 responses) from 2002 2005. A sample enriched for chronic...
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought establish more robust measures this association and potential gene-environment interactions using longitudinal data an established cohort study.Associations between TRAP (nitrogen dioxide (NO2) distance major roads) wheeze, asthma prevalence lung function were investigated in participants Tasmanian Longitudinal Health...
The term "pre-chronic obstructive pulmonary disease" ("pre-COPD") refers to individuals at high risk of developing COPD who do not meet conventional spirometric criteria for airflow obstruction. New approaches identifying these are needed, particularly in younger populations.
ABSTRACT Background and Objective The impact of lifetime body mass index (BMI) trajectories on adult lung function abnormalities has not been investigated previously. We associations BMI from childhood to mid‐adulthood with deficits COPD in mid‐adulthood. Methods Five ( n = 4194) age 5 43 were identified the Tasmanian Longitudinal Health Study. Lung outcomes defined using spirometry at 45 53 years. Associations between these multivariable regression. Results Compared average trajectory,...
Noninvasive markers of airway inflammation are needed for use in research and clinical practice childhood asthma. Induced sputum exhaled nitric oxide well established as direct asthma research. Sputum can be induced from children >6 yrs using inhalation hypertonic saline, and, if appropriate, combined with an assessment responsiveness to saline. The success rate induction is 68-100%. Most studies have processed the plug selection method, show that dominant cell normal macrophage, upper...
Exhaled nitric oxide (NO) may be derived from constitutive NO synthase (NOS) in normal airways, but the increased concentration asthma is likely to inducible NOS expressed inflamed airways. To investigate this, we administered a nonselective inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), and selective inhibitor of NOS, aminoguanidine, by nebulization double-blind, placebo-controlled manner both subjects with asthma. L-NAME resulted significant reduction exhaled compared saline control...
Exhaled breath condensate (EBC) is increasingly studied as a noninvasive research method of sampling the lungs, measuring several biomarkers. The exact site origin substances measured in EBC unknown, clinical applicability technique. Special techniques might be needed to measure biomarkers.To assess biomarker concentrations disease and investigate EBC, we compared bronchoalveolar lavage (BAL) biomarkers 49 patients undergoing bronchoscopy for indications.We exhaled nitric oxide,...
Phosphodiesterase (PDE) inhibitors have potential as alternatives or adjuncts to glucocorticoid therapy in asthma. We compared roflumilast (a selective PDE4 inhibitor) with pentoxifylline nonselective and dexamethasone ameliorating the lesions of chronic asthma a mouse model. BALB/c mice sensitized ovalbumin were chronically challenged aerosolized antigen for 6 weeks. During weeks 5 6, groups animals treated by daily gavage intraperitoneal injection. Airway hyper-reactivity (AHR) was...
Inhaled tumour necrosis factor alpha (TNF alpha) has previously been shown to induce airway neutrophilia and increased reactivity in normal subjects. It was hypothesised that a similar challenge would increase those with mild asthma, but the inflammatory profile may differ.Ten asthmatic subjects were recruited on basis of clinical asthma either sensitivity methacholine within range defined for or 20% improvement forced expiratory volume (FEV(1)) after 200 micro g salbutamol. Subjects inhaled...
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Soluble mesothelin-related protein (SMRP) is raised in epithelial-type malignant mesothelioma (MM), but the utility of SMRP screening for MM unknown.We aimed to evaluate an asbestos-exposed cohort.A total 538 subjects were studied. Those with elevated (> or =2.5 nM) underwent further investigation including positron emission tomography/computed tomography.Mean (+/-SD) healthy exposed asbestos (n = 223) was 0.79 (+/-0.45) nM. Fifteen had SMRP, whom one lung cancer, which successfully...
A syndrome of subacute respiratory distress, severe metabolic bone disease affecting the thoracic cage, and mild cholestasis occurred in 4 small preterm infants during first three months life was associated with considerable morbidity. The early radiological features chest resembled thos Mikity-Wilson syndrome, which disorder may be confused. After spontaneous improvement hepatic function 3 fully recovered. fourth died paralytic ileus. Various nutritional absorptive abnormalities probably...