A5003111166- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Respiratory and Cough-Related Research
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Inhalation and Respiratory Drug Delivery
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Cardiovascular and Diving-Related Complications
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Issues in Pregnancy
- Hemodynamic Monitoring and Therapy
- Neonatal Respiratory Health Research
- Cardiovascular and exercise physiology
- Coronary Artery Anomalies
- Smoking Behavior and Cessation
- Delphi Technique in Research
- Chronic Disease Management Strategies
- Health Promotion and Cardiovascular Prevention
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
University of Copenhagen
2016-2025
Copenhagen University Hospital
2016-2025
Charité - Universitätsmedizin Berlin
2000-2025
Frederiksberg Hospital
2015-2024
Gentofte Hospital
2015-2024
Population Council
2015-2024
Hvidovre Hospital
2012-2023
Herlev Hospital
2005-2023
Poliklinik für Zahnärztliche Prothetik
2021
Bispebjerg Hospital
2002-2020
Although the prevalence of asthma and morbidity related to are increasing, little is known about natural history lung function in adults with this disease.
Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume 1 second (FEV1) over time. Yet it possible that a normal FEV1 could also lead COPD persons whose maximally attained less than population norms.We stratified participants three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and Lovelace Smokers Cohort) according lung function (FEV1 ≥80% or <80% of predicted value) at cohort inception...
<b>Background:</b> Information about the influence of regular physical activity on course chronic obstructive pulmonary disease (COPD) is scarce. A study was undertaken to examine association between and both hospital admissions for COPD all-cause specific mortality in subjects. <b>Methods:</b> From a population-based sample recruited Copenhagen 1981–3 1991–4, 2386 individuals with (according lung function tests) were identified followed until 2000. Self-reported at baseline classified into...
The association between low body mass index (BMI) and poor prognosis in patients with chronic obstructive pulmonary disease (COPD) is a common clinical observation. We prospectively examined whether BMI an independent predictor of mortality subjects COPD from the Copenhagen City Heart Study. In total, 1,218 men 914 women, aged 21 to 89 yr, airway obstruction defined as FEV1-to-FVC ratio less than 0.7, were included analyses. Spirometric values, BMI, smoking habits, respiratory symptoms...
The benefits of triple therapy for chronic obstructive pulmonary disease (COPD) with an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and β2-agonist (LABA), as compared dual (either glucocorticoid–LABA or LAMA–LABA), are uncertain.
Smokers are more prone to develop chronic obstructive pulmonary disease (COPD) than non-smokers, but this finding comes from studies spanning 10 years or less. The aim of study was determine the 25 year absolute risk developing COPD in men and women general population.As part Copenhagen City Heart Study, 8045 aged 30-60 with normal lung function at baseline were followed for years. Lung measurements collected mortality during observation period analysed.The percentage ranged 96% never...
Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population, harmful effect low BMI due to deleterious effects fat-free (FFMI; mass/weight(2)).We explored distribution FFMI and its association with population-based cohort patients COPD.We used data on 1,898 COPD identified epidemiologic study Copenhagen. FFM was measured using bioelectrical impedance analysis. Patients were followed up for mean 7 yr between mortality...
Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased CRP in individuals airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study median of 8-yr follow-up 1,302 selected the Copenhagen City Heart Study.Measurements Main Results: measured at baseline, recorded COPD admissions deaths...
We have previously reported that regular physical activity reduces risk of chronic obstructive pulmonary disease (COPD) exacerbation. hypothesized higher levels could reduce the COPD by modifying smoking-related lung function decline.To estimate longitudinal association between and FEV(1) FVC decline risk.A population-based sample (n = 6,790) was recruited assessed with respect to activity, smoking, function, other covariates, in Copenhagen 1981-1983, followed until 1991-1994. Mean level...
Recent findings suggest that females may be more susceptible than males to the deleterious influence of tobacco smoking in developing chronic obstructive pulmonary disease (COPD). This paper studies interaction gender and on development COPD as assessed by lung function hospital admission. A total 13,897 subjects, born after 1920, from two population studies, 9,083 Copenhagen City Heart Study (CCHS) 4,814 Glostrup Population Studies (GPS), were followed for 7-16 yrs. Data linked with...
Whether high blood eosinophils are associated with chronic obstructive pulmonary disease (COPD) exacerbations among individuals COPD in the general population is largely unknown.To test hypothesis that predict exacerbations.Among 81,668 Copenhagen General Population Study, we examined 7,225 based on spirometry. We recorded at baseline and future longitudinally, defined as moderate (short-course treatment systemic corticosteroids) or severe (hospitalization). also assessed exacerbation risk a...
<h3>Importance</h3>Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients.<h3>Objective</h3>To test the hypothesis that elevated levels inflammatory biomarkers individuals with stable COPD are associated an increased risk having exacerbations.<h3>Design, Setting, Participants</h3>Prospective cohort study examining 61 650 participants spirometry measurements from Copenhagen City Heart Study (2001-2003)...
Background— The aims of this study were to validate MRI-derived right ventricular (RV) pressure-volume loops for assessment RV myocardial contractility and then apply technique in patients with chronic pressure overload contractility, pump function, VA coupling. Methods Results— Flow-directed catheters guided under MR fluoroscopy (1.5 T) into the invasive measurements. Simultaneously, volumes mass assessed from cine MRI. From sampled data, constructed, maximal elastance indexed (E max_i )...
The new Global Initiative for Obstructive Lung Disease (GOLD) stratification of chronic obstructive pulmonary disease (COPD) into categories A, B, C, and D is based on symptoms, level lung function, history exacerbations.To investigate the abilities this to predict clinical course COPD.Two similar population studies were performed in an area Copenhagen including 6,628 individuals with COPD.The patients monitored average period 4.3 years regarding COPD exacerbations, hospital admissions,...
Rationale: Patients with chronic obstructive pulmonary disease (COPD) have evidence of systemic inflammation that may be implicated in the development comorbidities.Objectives: To test hypothesis elevated levels three inflammatory biomarkers are associated increased risk comorbidities COPD.Methods: We examined 8,656 patients COPD from two large Danish population studies and during a median 5 years' follow-up recorded hospital admissions due to major as endpoints.Measurements Main Results:...
Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatment) trial demonstrated a significant reduction in all-cause mortality (ACM) risk with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI patients chronic obstructive pulmonary disease (COPD) at future exacerbations. Five hundred seventy-four were censored original analysis owing to incomplete vital status information.Objectives: Report ACM and impact stepping down therapy,...
Background It is unclear if type-2 inflammation associated with accelerated lung function decline in individuals asthma and chronic obstructive pulmonary disease (COPD). We tested the hypothesis that indicated by elevated blood eosinophils (BE) fraction of exhaled nitric oxide (FeNO) general population. Methods included adults from Copenhagen General Population Study measurements BE (N=15 605) FeNO (N=2583) a follow-up examination assessed forced expiratory volume 1 s (FEV ) preceding 10...
In the recently published guidelines of Global Initiative for Chronic Obstructive Lung Disease (GOLD) chronic obstructive pulmonary disease (COPD), staging system included a Stage 0 subjects without airways obstruction but with respiratory symptoms, denoting these “at risk” COPD. Our aim was to validate this approach using data from three surveys in The Copenhagen City Heart Study, which sample general population examined at baseline and which, after 5 15 years, spirometry performed all...
Chronic obstructive pulmonary disease has been associated with a high frequency of arrhythmias. Few studies have analysed the role reduced lung function in predicting atrial fibrillation (AF). The aim present study was to investigate relationship between forced expiratory volume one second (FEV 1 ) and risk first episode AF prospective study. Data from 13,430 males females without previous myocardial infarction, who participated Copenhagen City Heart Study, were analysed. New assessed at...
An association between low body mass index (BMI) and poor prognosis in patients with chronic obstructive pulmonary disease (COPD) has been found a number of studies. The prevalence prognostic importance weight change unselected subjects COPD was examined. Subjects COPD, defined as forced expiratory volume one second/forced vital capacity <0.7 the Copenhagen City Heart Study who attended two examinations 5 yrs apart, were followed for 14 COPD-related all-cause mortality. proportion lost...
The association of chronic mucus hypersecretion and mortality is a matter debate. We wished to determine whether the relationship between obstructive pulmonary disease (COPD)-related could be explained by proneness infection. followed 14,223 subjects both sexes for 10-12 yrs. Cases where COPD was an underlying or contributory cause death (n = 214) were included, hospital records obtained when possible 101). From presence increased mucus, purulent fever, leucocytosis infiltration on chest...