A5027026850- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Infective Endocarditis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Coronary Interventions and Diagnostics
- Viral Infections and Immunology Research
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Coronary Artery Anomalies
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Issues in Pregnancy
- Advanced X-ray and CT Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging Techniques and Applications
Charité - Universitätsmedizin Berlin
2016-2025
German Centre for Cardiovascular Research
2016-2025
Deutsches Herzzentrum der Charité
2016-2025
Deutsches Herzzentrum München
2015-2025
Humboldt-Universität zu Berlin
2019-2025
Freie Universität Berlin
2019-2025
Berlin Heart (Germany)
2009-2023
LMU Klinikum
2018
Ludwig-Maximilians-Universität München
2018
Swiss Paediatric Oncology Group
2016
Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, older children contributes to significant morbidity mortality. However, current approaches caring for pediatric patients pulmonary have been limited by the lack of consensus guidelines from experts field. In a joint effort American Heart Association Thoracic Society, panel experienced clinicians clinician-scientists was assembled review literature make recommendations on...
Background— The aims of this study were to validate MRI-derived right ventricular (RV) pressure-volume loops for assessment RV myocardial contractility and then apply technique in patients with chronic pressure overload contractility, pump function, VA coupling. Methods Results— Flow-directed catheters guided under MR fluoroscopy (1.5 T) into the invasive measurements. Simultaneously, volumes mass assessed from cine MRI. From sampled data, constructed, maximal elastance indexed (E max_i )...
Dysfunction of valved conduits in the right ventricular outflow tract (RVOT) limits durability and enforces repeated surgical interventions. We report on our combined two-centre experience with percutaneous pulmonary valve implantation (PPVI). One hundred two patients RVOT dysfunction [median weight: 63 kg (54.2–75.9 kg), median age: 21.5 years (16.2–30.1 years), diagnoses: TOF/PA 61, TAC 14, TGA 9, other 10, AoS post-Ross-OP 8] were scheduled for PPVI since December 2006. Percutaneous was...
Cardiac MRI is important in the treatment of children with congenital heart disease, but sufficient normative data are lacking. For ventricular volumes and mass, we sought to deliver reference centiles investigate sex effects.We included 114 healthy adolescents, uniformly distributed spanning an age range 4 20 years, as required by Lambda-Mu-Sigma method achieve a percentile distribution, thus avoiding arbitrary categories. Subjects underwent axial volumetry (1.5-T scanner) using...
The concentration of gadopentetate dimeglumine in myocardium and blood can be assessed from T1 measurements used to calculate the extracellular volume (ECV) myocardium. We hypothesized that diffuse myocardial fibrosis a small-animal model could quantitatively by measuring ECV using Look-Locker inversion recovery mapping.Sprague-Dawley rats (n=10) were subjected continuous angiotensin-2 (AT2) infusion for 2 weeks via subcutaneously implanted minipump system. Magnetic resonance imaging (MRI)...
Purpose To reduce the need for diagnostic catheterization and optimize treatment in a variety of congenital heart diseases, magnetic resonance imaging (MRI)‐based computational fluid dynamics (CFD) is proposed. However, data about accuracy CFD clinical context are still sparse. fill this gap, study compares MRI‐based to coarctation aorta (CoA) setting. Materials Methods Thirteen patients with CoA were investigated by routine MRI prior catheterization. 3D whole‐heart was used reconstruct...
<h3></h3> The European Paediatric Pulmonary Vascular Disease (PVD) Network is a registered, non-profit organisation that strives to define and develop effective, innovative diagnostic methods treatment options in all forms of paediatric pulmonary hypertensive vascular disease, including specific such as arterial hypertension (PAH)-congenital heart (PH) associated with bronchopulmonary dysplasia, persistent PH the newborn, related cardiac dysfunction. <h3>Methods</h3> writing group members...
Abstract Purpose: To further validate the quantitative use of flow‐sensitive four‐dimensional velocity encoded cine magnetic resonance imaging (4D VEC MRI) for simultaneously acquired venous and arterial blood flow in healthy volunteers abnormal patients with congenital heart disease. Materials Methods: Stroke volumes (SV) obtained thoracic vessels were compared between standard two‐dimensional (2D), 4D MRI without respiratory navigator gating (gated/nongated) ( n = 7). In addition, SV...
Abstract Purpose: To evaluate the use of four‐dimensional (4D) velocity‐encoded magnetic resonance imaging (VEC MRI) for blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow. Materials Methods: Peak velocities (Vmax) stroke volumes (SV) were quantified by 2D 4D VEC MRI volunteers ( n = 7) 18). Measurements performed above aortic pulmonary both techniques and, additionally, at multiple predefined planes ascending aorta trunk within dataset. In...
Systemic-to-pulmonary collateral flow (SPCF) may constitute a risk factor for increased morbidity and mortality in patients with single-ventricle physiology (SV). However, clinical research is limited by the complexity of multi-vessel two-dimensional (2D) cardiovascular magnetic resonance (CMR) measurements. We sought to validate four-dimensional (4D) velocity acquisition sequence concise quantification SPCF distribution SV. 29 SV prospectively underwent CMR (1.5 T) (n = 14 bidirectional...
<b>Objectives:</b> To validate in vivo a magnetic resonance imaging (MRI) method for measurement of pulmonary vascular resistance (PVR) and subsequently to apply this technique patients with hypertension (PHT). <b>Methods results:</b> PVR was assessed from velocity encoded cine MRI derived artery (PA) flow volumes simultaneously determined invasive PA pressures. For pressure measurements directed catheters were guided under fluoroscopy at 1.5 T into the PA. In preliminary validation studies...
Abstract Purpose: To investigate the impact of interinstitutional variance (=interobserver between institutions) for volumetric and flow cardiac MR (CMR) data if training on image reading could improve bias. Materials Methods: In a three‐center study, total 32 adults with repaired Tetralogy Fallot 23 controls underwent CMR using standardized protocols ventricular volumes/mass (by transverse short‐axis cine‐MRI) pulmonary/aortic blood by velocity‐encoded MRI (VEC‐MRI). Data were analyzed...
Background— Anatomic and functional observations suggest that the right ventricle (RV) can be analyzed in terms of its inlet, apical trabecular, outlet components. Our study was designed to evaluate regional adaptation these components different conditions loading, with additional analysis surgical techniques used for primary repair. Methods Results— We studied prospectively 45 patients tetralogy Fallot (age, 20.5�8.1 years) 24 control subjects 20.1�5.8 years). All were by using cardiac MRI....
The role, interplay, and relative importance of the multifactorial hemodynamic myocardial mechanisms causing dysfunction Fontan circulation remain incompletely understood.Using an MRI catheterization technique, we performed a differential analysis pulmonary vascular resistance aortopulmonary collateral blood flow in conjunction with global ventricular pump function, myocontractility (end-systolic pressure-volume relation), diastolic compliance (end-diastolic relation) 10 patients at rest...
The impact of gender and age on cardiac function by magnetic resonance (CMR) in repaired tetralogy Fallot (TOF) is unknown, which limits the value currently discussed volumetric thresholds accuracy individual follow-up.In a nationwide, prospective, 14-center study, 407 consecutive patients with TOF (age, 17.9±8.3 years; range, 8-59 226 male patients) underwent standardized CMR ventricular volumetry flow quantification (pulmonary artery/ascending aorta). There were no sex differences for at...
The atria play an important role in cardiac performance. We evaluated their function and the atrioventricular interaction operated patients with tetralogy of Fallot (TOF). Twenty who had undergone surgical repair TOF seven controls were investigated. Patients residual pulmonary but no major tricuspid valve insufficiency. Atrial ventricular strain rates obtained by echocardiographic speckle tracking. Cine MRI-derived volumetric analysis provided atrial time volume change curves yielding...
Computational models of cardiac electromechanics (EM) are increasingly being applied to clinical problems, with patient-specific generated from high fidelity imaging and used simulate patient physiology, pathophysiology response treatment. Current structured meshes limited in their ability fully represent the detailed anatomical data available images capture complex varied anatomy geometric accuracy. In this paper, we review state art image-based personalization for biophysically detailed,...
Purpose To validate the use of particle traces derived from four-dimensional (4D) flow magnetic resonance (MR) imaging to quantify in vivo caval contribution pulmonary arteries (PAs) patients who had been treated with Fontan procedure. Materials and Methods The institutional review boards approved this study, informed consent was obtained. Twelve healthy volunteers 10 circulation were evaluated. trace method consists creating a region interest (ROI) on blood vessel, which is used emit...
This study was conducted to determine the effects of chronic pulmonary insufficiency (PI) on right (RV) and left (LV) ventricular function in young growing swine.Six PI 5 control animals were studied. induced by transcatheter placement stents across valve. Indices systolic (ejection fraction, cardiac output, functional reserve), diastolic (compliance), myocardial contractility (the slope relationship end-systolic pressure versus volume [Emax] dP/dtmax-end-diastolic [MdP/dt]) assessed within...