A5068655629- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Conditions and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Vascular anomalies and interventions
- Speech and Audio Processing
- Aortic Disease and Treatment Approaches
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
- Kawasaki Disease and Coronary Complications
- Congenital Diaphragmatic Hernia Studies
- Phonetics and Phonology Research
- Cardiac tumors and thrombi
- Language, Metaphor, and Cognition
- Speech Recognition and Synthesis
- Trauma Management and Diagnosis
- Tracheal and airway disorders
Northwestern University
2020-2023
Children's Hospital of Michigan
2012-2022
Prince of Wales Hospital
2022
Corewell Health Children's
2021
Wayne State University
2007-2019
Driscoll Children's Hospital
2017
Children's Hospital Central California
2017
University of Virginia
2017
East Carolina University
2017
Michigan United
2015-2017
Abstract Background: We report a multi‐institutional experience with intravascular stenting (IS) for treatment of coarctation the aorta. Methods and Results: Data was collected retrospectively by review medical records from 17 institutions. The data broken down to prior 2002 after further analysis. A total 565 procedures were performed median age 15 years (mean = 18.1 years). Successful reduction in post stent gradient (<20 mm Hg) or increase descending aorta (DAo) ratio >0.8 achieved...
We report a multiinstitutional study on intermediate-term outcome of intravascular stenting for treatment coarctation the aorta using integrated arch imaging (IAI) techniques.Medical records 578 patients from 17 institutions were reviewed. A total 588 procedures performed between May 1989 and Aug 2005. About 27% (160/588) followed up by further IAI their (MRI/CT/repeat cardiac catheterization) after initial stent procedures. Abnormal studies included: presence dissection or aneurysm...
Background— Prospective data on the medium-term safety and effectiveness of AMPLATZER Septal Occluder in clinical practice are not available. The objective this study was to prospectively evaluate risk hemodynamic compromise obtain survival patients implanted with for percutaneous closure secundum atrial septal defects. Methods Results— Subjects were enrolled at 50 US sites followed 2 years. Between 2008 2012, defect attempted 1000 (aged 0.3–83.6 years, mean 21±22 years). Procedural occurred...
To evaluate postdiscovery outcome of coronary artery fistulae (CAF). CAF treatment sequelae and risk factors for thrombosis have not been adequately evaluated.Outcome on follow-up 16 patients with was reviewed. Risk adverse events were assessed based type, size, CAF.Median age 10 years (0.01-56). Seven had large, four medium, five small sizes CAF. Eight proximal 8 distal type There 7 in the intervention group (IG) 9 nonintervention (NIG). In IG, 1 myocardial infarction (MI) <24 hr following...
This study was conducted to determine the effects of chronic pulmonary insufficiency (PI) on right (RV) and left (LV) ventricular function in young growing swine.Six PI 5 control animals were studied. induced by transcatheter placement stents across valve. Indices systolic (ejection fraction, cardiac output, functional reserve), diastolic (compliance), myocardial contractility (the slope relationship end-systolic pressure versus volume [Emax] dP/dtmax-end-diastolic [MdP/dt]) assessed within...
To assess the feasibility of using magnetic resonance (MR) imaging to guide stent deployment in pulmonary valve and artery evaluate, after deployment, position morphology blood flow through stent.Angiography 1.5-T MR were performed a dual-imaging suite. Nitinol stents placed main five pigs by guidance. For interactive monitoring catheter manipulation delivery, balanced fast field-echo T1-weighted turbo sequences used. Visualization delivery system was based on T2* (with air as contrast...
Abstract Background : Over the past three decades, transcatheter occlusion of patent ductus arteriosus (PDA) has evolved to be procedure choice. Gianturco and Flipper coils are most commonly used in United States for closure small moderate size PDAs. For larger PDAs, interventionalists use Amplatzer Duct Occluder (ADO) those Europe ADO or Nit‐Occlud Coils (NOC). A comparison between coils, ADO, NOC never been made. Objective To compare success complication rate associated with four different...
To investigate whether age and valve size at implant contribute to outcomes after Melody transcatheter pulmonary replacement (TPVR).Patient longevity of surgical valves.All patients discharged with a in the position, as part three prospective multicenter studies, comprised study cohort. Acute time-related were analyzed according age: children (≤12 years), adolescents (13-18 young adults (19-29 older (≥30 years).Successful implantation occurred 49 children, 107 adolescents, 96 adults, 57...
Stem cell-derived organoid models hold great promise to model tissue-specific disease. To enable this, it is crucial determine how their composition compares endogenous organs. However, technologies such as spatial transcriptomics (STs) that can inform on regional molecular identity have been challenging apply organoids. Here we present the first systematic profiling of multiple organoids (brain, heart muscle,heart valve, kidney, lung, cartilage, and blood) using Stereo-seq. We describe...
Background Patients with endovascular stent implantation for the treatment of right ventricular outflow tract obstruction are often left incomplete relief and significant pulmonary regurgitation. A noninvasive reproducible method monitoring such patients is desirable. MRI in presence a stent, however, has to overcome problem potential metallic artifacts. Methods Results Under x-ray fluoroscopic guidance, nitinol stents were placed across valve 6 young pigs induce Five additional served as...
Untreated thoracic aortic coarctation leads to early death predominantly because of hypertension and its cardiovascular sequelae. Surgical treatment has been available for > 50 years improved survival. More recently, endovascular techniques have offered a minimally invasive alternative traditional open repair. Early intermediate results suggest angioplasty stenting an important role in the management coarctation, particularly adults older children.
Background The number of low birth weight infants with congenital heart disease is increasing and catheterizations may have an increased risk for mortality morbidity. Objectives We investigate the outcome complications cardiac in weighing < 2.5 kg. Methods Retrospective review catheterization records from 1995 to 2010 demographics, procedure, outcome, follow‐up data were collected. Results Of 101 performed 88 patients, 45 (45%) interventional. Balloon atrial septostomy ( n = 23),...
Abstract Background Acute pulmonary embolism is a life-threatening condition and rarely occurs in children. In adults, catheter-directed therapy emerges as potentially safer effective therapeutic option. However, there paucity of data on the safety efficacy for We report single-centred experience acute Methods This retrospective study children who had no CHD underwent at Detroit Medical Center during 12-year period from 2005 to 2017. Demographic clinical associated with were collected along...
Abstract Transcatheter occlusion of patent ductus arteriosus (PDA) using Gianturco coils (GCs) has been performed for the past decade. However, little written regarding anatomical and hemodynamic predictors successful PDA in infants. This report is to evaluate outcome transcatheter symptomatic infants less than 8 kg assess occlusion. Retrospective review catheterization charts cineangiograms 42 who underwent cardiac attempted their was conducted. The angiographic data evaluated included...
Adjustment of myocardial mass to work load is a fundamental characteristic the heart. We studied effect verapamil, calcium channel blocker, on growth and function chick embryonic ventricle. treated stage 18 embryos with verapamil delivered extraembryonic vascular bed by miniosmotic pump compared them saline-treated control untreated embryos. At stages 24, 27, 29, we measured ventricular pressure dP/dt servo-null system, dorsal aortic stroke volume dV/dt pulsed-Doppler, embryo wet weights....
This study was conducted to determine the effects of chronic combined pulmonary stenosis and insufficiency (PSPI) on right (RV) left ventricular (LV) function in young, growing swine. Six pigs with PSPI were studied, data compared previously published animals isolated controls. Indexes systolic (stroke volume, ejection fraction, cardiac functional reserve), myocardial contractility (slope end-systolic pressure-volume change pressure over time-end-diastolic volume relationship), diastolic...
Abstract Background Atrial transseptal puncture (TSP) for cardiac catheterization procedures remain challenging in children and adults with complex congenital heart disease (CHD). Objectives We sought to evaluate our experience using radiofrequency (RF) current via surgical electrocautery needle TSP facilitate diagnostic interventional procedures. Methods Retrospective chart review of all patients (pts) who underwent RF energy (10–25 W) from three centers January 2011 2017 were evaluated....