A5062979528- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical studies and practices
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Adrenal Hormones and Disorders
- Child and Adolescent Health
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Pharmacological Effects and Assays
- IL-33, ST2, and ILC Pathways
- Delphi Technique in Research
- Eosinophilic Esophagitis
- Sinusitis and nasal conditions
- Respiratory Support and Mechanisms
- Drug-Induced Adverse Reactions
- Infant Health and Development
- Studies on Chitinases and Chitosanases
- Respiratory viral infections research
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
AstraZeneca (United States)
2023-2025
Wilmington University
2023
AstraZeneca (Brazil)
2023
University of Colorado Denver
2012-2022
National Jewish Health
2010-2022
Research Triangle Park Foundation
2005-2021
GlaxoSmithKline (United States)
2006-2021
Children's Hospital Colorado
2015-2020
Denver School of Nursing
1994-2020
University of Colorado System
2016
For children who have uncontrolled asthma despite the use of low-dose inhaled corticosteroids (ICS), evidence to guide step-up therapy is lacking.We randomly assigned 182 (6 17 years age), had while receiving 100 microg fluticasone twice daily, receive each three blinded therapies in random order for 16 weeks: 250 daily (ICS step-up), plus 50 a long-acting beta-agonist (LABA or 5 10 mg leukotriene-receptor antagonist (LTRA step-up). We used triple-crossover design and composite outcomes...
ContextLong-acting β2-agonists are prescribed for patients with persistent asthma and sometimes used without inhaled corticosteroids (ICSs). No evidence exists, however, to support their use as monotherapy in adults asthma.ObjectiveTo examine the effectiveness of salmeterol xinafoate, a long-acting β2-agonist, replacement therapy whose is well controlled by low-dose triamcinolone acetonide, an ICS.Design SettingA 28-week, randomized, blinded, placebo-controlled, parallel group trial...
N PATIENTS WITH PERSISTENT ASTHMA inadequately controlled by treatment with a low dose of inhaled corticosteroids (ICSs), the addition long-acting  2 -agonist 1-4 provides an incremental improvement in asthma control exceeding that achieved increasing dosages ICS.We anticipated once this occurred, many patients would question whether their dosage ICS could be reduced or even eliminated.Evidence both supporting 5,6 and refut-
From the Childhood Asthma Management Program cohort, which was randomly assigned to receive budesonide, nedocromil, or placebo for 4–6 years, we determined prevalence of and factors associated with at least 1% per year loss in postbronchodilator FEV1% predicted. Participants who had a significant reduction predicted (SRP), comprised 25.7% cohort (n = 990). Using logistic regression, predictors SRP baseline were younger age (p 0.0005), male sex < 0.0001), clinic 0.02), higher 0.02)....
We have recently demonstrated that the combination of IL-2 and IL-4 blunts T cell responses to glucocorticoids in steroid resistant (SR) asthma by reducing glucocorticoid receptor (GCR)-binding affinity. Since immune activation appears be involved acquisition resistance, we sought identify whether other cytokines could also induce diminished GCR-binding In current report, utilizing a [3H]dexamethasone radioligand-binding assay Scatchard analysis, found IL-13, cytokine with similar actions as...
Allergen exposure can confound the management of asthma. To understand potential mechanisms by which allergens increase steroid requirements in atopic asthmatics, we examined effects on glucocorticoid receptor (GCR) binding affinity and (GC) responsiveness peripheral blood mononuclear cells (PBMC) from asthmatics. A significant reduction (p < 0.001) GCR (Kd) was observed ragweed-allergic asthmatics during ragweed pollen season compared with PBMC obtained before after season. In vitro...
Although National Heart Lung Institute (NHLBI) guidelines categorize asthma severity based on spirometry, few studies have evaluated the utility of these spirometric values in grading children. Asthma is thought to be progressive, but little known about loss lung function childhood. This study sought determine indices children from 4-18 years age. Retrospective cross-sectional analysis was performed all spirometries done at Jewish Medical and Research Center 1999-2002. In total, 2,728 24,388...
The aim of this study was to compare air-trapping as quantified by high-resolution computed tomography (HRCT) the chest with measures lung function and airway inflammation in children mild moderate asthma. Plethysmography indices, respiratory resistance, reactance before after bronchodilator impulse oscillation (IOS), exhaled nitric oxide (eNO), total eosinophil count (TEC), serum cationic protein (ECP) levels were measured 21 subjects. A single-cut HRCT image at end-expiration obtained....