A5032630701- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Ion channel regulation and function
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Mechanical Circulatory Support Devices
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diet and metabolism studies
- Adipose Tissue and Metabolism
Osaka City General Hospital
2020-2025
Osaka Prefectural Medical Center
2020-2025
Tokyo Metropolitan University
2022-2025
Osaka Metropolitan University
2022-2025
Metropolitan University
2024
Hyogo Prefectural Nishinomiya Hospital
2023
Sapporo Science Center
2020-2023
Osaka City University
2011-2022
Sakurabashi Watanabe Hospital
2018-2022
Fukuyama Cardiovascular Hospital
2014-2021
The molecular mechanism for the transition from cardiac hypertrophy, an adaptive response to biomechanical stress, heart failure is poorly understood. mitogen-activated protein kinase p38alpha a key component of stress pathways in various types cells. In this study, we attempted explore vivo physiological functions hearts. First, generated mice with floxed alleles and crossbred them expressing Cre recombinase under control alpha-myosin heavy-chain promoter obtain cardiac-specific knockout...
Left ventricular remodeling that occurs after myocardial infarction (MI) and pressure overload is generally accepted as a determinant of the clinical course heart failure. The molecular mechanism this process, however, remains to be elucidated. Apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein plays an important role in stress-induced apoptosis. We used ASK1 knockout mice (ASK -/- ) test hypothesis involved development left remodeling. ASK hearts showed no morphological...
Background— The time course of neointimal formation after stent implantation has not been studied extensively by angioscopy in the drug-eluting era. Methods and Results— Serial angioscopic findings at first follow-up (3.6±1.1 months), second (10.5±1.6 third (21.2±2.2 months) were compared between sirolimus-eluting stents (SES, n=17) bare-metal (BMS, n=11). Neointimal coverage, thrombus, presence yellow plaques underneath assessed. coverage was graded as follows: grade 0, struts fully...
The Raf/MEK/extracellular signal–regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis is implicated an important contributor to the pathogenesis of cardiac hypertrophy heart failure. To examine in vivo role Raf-1 heart, we generated muscle–specific Raf-1–knockout (Raf CKO) mice with Cre-loxP–mediated recombination. demonstrated left ventricular systolic dysfunction dilatation without or lethality. Raf CKO showed a...
Substantial portion of early arrhythmia recurrence after catheter ablation for atrial fibrillation (AF) is considered to be due irritability in left atrium (LA) from the procedure. We sought evaluate whether 90-day use antiarrhythmic drug (AAD) following AF could reduce incidence and thereby promote reverse remodelling LA, leading improved long-term clinical outcomes. A total 2038 patients who had undergone radiofrequency paroxysmal, persistent, or long-lasting were randomly assigned either...
Most of recurrent atrial tachyarrhythmias after pulmonary vein isolation (PVI) for fibrillation (AF) are due to reconnection PVs. The aim the present study was evaluate whether elimination adenosine triphosphate (ATP)-induced dormant PV conduction by additional energy applications during first ablation procedure could reduce incidence tachyarrhythmias. We randomly assigned 2113 patients with paroxysmal, persistent, or long-lasting AF either ATP-guided PVI (1112 patients) conventional (1001...
Background: Empagliflozin reduces the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular disease. We sought to elucidate effect empagliflozin as an add-on therapy on decongestion renal function admitted acute decompensated failure. Methods: The study was terminated early due COVID-19 pandemic. enrolled 59 consecutive Patients were randomly assigned receive either (n=30) or conventional glucose-lowering (n=29). performed laboratory tests at baseline...
The Raf/MEK/extracellular signal–regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis is implicated an important contributor to the pathogenesis of cardiac hypertrophy heart failure. To examine in vivo role Raf-1 heart, we generated muscle–specific Raf-1–knockout (Raf CKO) mice with Cre-loxP–mediated recombination. demonstrated left ventricular systolic dysfunction dilatation without or lethality. Raf CKO showed a...
Previous studies could not demonstrate any benefit of more intensive ablation in addition to pulmonary vein isolation (PVI) including complex fractionated atrial electrogram (CFAE) and linear for recurrence the initial catheter persistent fibrillation (AF). This study aimed establish non-inferiority PVI alone plus these additional strategies.Patients with AF who underwent an (n = 512, long-standing AF; 128 cases) were randomly assigned a 1:1 ratio either (PVI-alone group) or CFAE and/or...
Ultrasound (US)-guided percutaneous needle biopsy is a useful diagnostic technique with short examination time and real-time monitoring at the bedside. However, there are only few studies that report on thoracic lesions, whereas computed tomography (CT)-guided well established. There also limited data comparing US- CT-guided biopsy. We aimed to clarify efficacy safety of US-guided for lesions adjacent chest wall.We retrospectively enrolled consecutive patients who underwent or biopsies wall...
Cigarette smoking-induced oxidative stress is known to be a key mechanism in COPD pathogenesis. Nuclear factor erythroid 2-related 2 (Nrf2) central transcription that regulates the antioxidant defense system. The aim of this study was compare Nrf2 expression subjects and control subjects, determine role protecting against stress-induced apoptosis. We enrolled 8 7 study. performed bronchial brushing by bronchoscopy obtained epithelial cells from airways. evaluated real-time PCR Western...
Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The activation nuclear factor erythroid 2-related 2 (Nrf2) is a key cellular defense mechanism against oxidative stress. Recent studies have shown that astaxanthin protects via Nrf2. In this study, we investigated emphysema suppression effect Nrf2 mice. Mice were divided into four groups: control, smoking, astaxanthin, and + smoking. mice smoking groups exposed to cigarette smoke for...
Differences in carcinogenesis and therapeutic efficacy according to ethnicity have been reported for lung cancer, understanding differences genetic mutation profiles among ethnicities is important interpreting the results of clinical trials, preventing carcinogenesis, individualizing treatment. However, no studies focused on different using large-scale genomic analysis data with detailed information smoking history, main cause cancer.To clarify between Caucasian Japanese subjects, we...
Background An optimal strategy for left atrial ablation in addition to pulmonary vein isolation (PVI) patients with persistent fibrillation (AF) has not been determined. Methods and Results We conducted an extended follow-up of the multicenter randomized controlled EARNEST-PVI (Efficacy Pulmonary Vein Isolation Alone Patients With Persistent Atrial Fibrillation) trial, which compared 12-month rhythm outcomes AF between a PVI-alone (n=248) or PVI-plus (n=248; PVI followed by additional...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a diagnostic procedure with adequate performance; however, its ability to provide specimens of sufficient quality and quantity for treatment decision-making in advanced-stage lung cancer may be limited, primarily due blood contamination. The use 0.96-mm miniforceps biopsy (MFB) permits true histological sampling, but the resulting small are unsuitable intended applications. Therefore, we introduced 1.9-mm...
The free radical scavenger 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone) is used to treat patients with ischemic brain damage. We and others reported previously that in vitro vivo reactive oxygen species (ROS) act as second messengers develop cardiac hypertrophy. In this study, we an murine model of pressure overload-induced hypertrophy examine the effects edaravone on left ventricular animals were subjected transverse thoracic aorta constriction, (10 mg/kg) was infused intraperitoneally...
Calpains make up a family of Ca(2+)-dependent intracellular cysteine proteases that include ubiquitously expressed μ- and m-calpains. Both are heterodimers consisting distinct large catalytic subunit (calpain 1 for μ-calpain calpain 2 m-calpain) common regulatory 4). The physiological roles remain unclear in the organs, including heart, but it has been suggested is activated by Ca(2+) overload diseased hearts, resulting cardiac dysfunction. In this study, cardiac-specific 4-deficient mice...
Abstract Background and objective Irisin is a recently identified hormone secreted by skeletal myocytes, which has been proposed to mediate the beneficial effects of exercise. Physical activity emphasized as one principal targets treatment for chronic obstructive pulmonary disease ( COPD ). This study was designed evaluate possibility using serum irisin level novel biomarker associated with physical in patients . Methods We measured 72 27 control subjects, investigated its correlation...
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