A5055039341- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Animal Genetics and Reproduction
- Hematopoietic Stem Cell Transplantation
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
- Pressure Ulcer Prevention and Management
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Reproductive biology and impacts on aquatic species
- Porphyrin Metabolism and Disorders
- Chromosomal and Genetic Variations
- Tracheal and airway disorders
- Fish Ecology and Management Studies
- Renal Diseases and Glomerulopathies
- Neonatal Health and Biochemistry
- Clinical Nutrition and Gastroenterology
- Burn Injury Management and Outcomes
- Genetic diversity and population structure
- Acute Myeloid Leukemia Research
- Sepsis Diagnosis and Treatment
- Wound Healing and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Tokyo Metropolitan University
2023-2025
Osaka Metropolitan University
2023-2025
Tottori University Hospital
2020-2024
Izumi City General Hospital
2019-2024
Pharmaceuticals and Medical Devices Agency
2009-2024
University of Toyama
2018-2024
Tottori University
2022-2023
Jichi Medical University
2023
Jichi Medical University Saitama Medical Center
2023
Kyushu University
2002-2021
Backgrounds A mouse receptor tyrosine kinase (RTK), mRor2, which belongs to the Ror‐family of RTKs consisting at least two structurally related members, is primarily expressed in heart and nervous system during development. To elucidate function we generated mice with a mutated mRor2 locus. Results Mice homozygous mutation died just after birth, exhibiting dwarfism, severe cyanosis, short limbs tails. Whole‐mount situ hybridization analysis showed that was branchial arches, limb/tailbuds,...
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.
Chronic obstructive pulmonary disease (COPD) is closely related to skeletal muscle dysfunction, and the evaluation of respiratory function has recently been recommended. We aimed investigate effects dysfunction on clinical outcomes. retrospectively reviewed medical records patients with COPD whose strength was measured between June 2015 December 2021. then analysed moderate-to-severe exacerbations after adjusting for confounding factors, including sex, age, forced expiratory volume in 1-s...
Defects in the xeroderma pigmentosum type B (XPB) gene (ERCC3), a DNA helicase involved nucleotide excision repair (NER) and an essential subunit of basal transcription factor, TFIIH, have been described only three families. We report new XPB families: one has two sisters with relatively mild (XP) symptoms not previously associated mutations severe XP/Cockayne syndrome (CS) complex symptoms. All XP-B cells had reduced NER post-ultraviolet (UV) cell viability. Surprisingly, from milder XP...
Backgrounds Drosophila neurospecific receptor tyrosine kinases (RTKs), Dror and Dnrk, as well Ror1 Ror2 RTKs, isolated from human neuroblastoma, have been identified a structurally related novel family of RTKs (Ror‐family RTKs). Thus far, little is known about the expression function mammalian Ror‐family RTKs. Results We murine mRor1 mRor2. Both mRor2 genes are induced upon neuronal differentiation P19EC cells. During in vitro , transiently induced, although that increases continuously....
Xeroderma pigmentosum group C (XP-C) is a rare autosomal recessive disorder. Patients with two mutant alleles of the XPC DNA repair gene have sun sensitivity and 1000-fold increase in skin cancers. Clinically normal parents XP-C patients one allele allele. As step toward evaluating cancer risk these heterozygotes we characterized cells from 16 XP families. We identified 15 causative mutations (5 frameshift, 6 nonsense 4 splicing) probands. All had premature termination codons (PTC) absence...
1. Minute but appreciable amounts of d-amino acids were detected in normal human plasma. 2. The content was significantly higher an elderly population (age 76 ± 6 years, mean sd, n = 41) than a younger group 42 4 26), i.e. 6.9 4.8 nmol/ml (mean range 0–18.8 nmol/ml) and 2.5 1.8 (range 0–6.3 for the groups, respectively. 3. Elevation plasma acid level observed patients with renal disease (3.6–52.6 nmol/ml), proportion to serum creatinine (n 50, r 0.726, P < 0.001), β2-microglobulin 34,...
The Mycoses Forum in Japan has developed management bundles for candidaemia to incorporate into bedside practice. aim of this study was investigate nationwide compliance with the and their impact on clinical outcomes. Non-neutropenic patients treated antifungals were surveyed. Bundles consist nine items complete. Data sent central office between July 2011 April 2012. Six hundred eight analysed. rate achieving all elements 6.9%, it increased 21.4% when analysed by bundle except oral switch....
The micronucleus test using fish peripheral blood has been introduced to assess the contamination of water with some mutagenic chemicals. applicability erythrocytes combining acridine orange (AO) fluorescent staining was evaluated as compared chromosomal aberration method. Peripheral cells were smeared on glass slides, fixed methanol, and stained AO. AO fluorescence microscopy could differentiate between young mature erythrocytes, thus only be observed. sensitivity detect clastogenic effects...
On March 11, 2011, a 9.1 magnitude earthquake occurred in the eastern Pacific Ocean off coast of northern Japan. A resulting tsunami struck Japan coast, causing >20,000 deaths, injuries and missing persons. Survivors' post-tsunami health nutritional status were surveyed one month after disaster school shelter Ishinomaki City. Hyogo College Medicine's relief team observations survivors' questionnaires used to assess disaster's effects on lifestyles gastrointestinal symptoms while residing...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a diagnostic procedure with adequate performance; however, its ability to provide specimens of sufficient quality and quantity for treatment decision-making in advanced-stage lung cancer may be limited, primarily due blood contamination. The use 0.96-mm miniforceps biopsy (MFB) permits true histological sampling, but the resulting small are unsuitable intended applications. Therefore, we introduced 1.9-mm...
The effects of DNA repair and transcription gene abnormalities in human pre-natal life have never been studied. Trichothiodystrophy (TTD) is a rare (affected frequency 10(-6)) recessive disorder caused by mutations genes involved nucleotide excision (NER) pathway transcription. Based on our novel clinical observations, we conducted genetic epidemiologic study to investigate gestational outcomes associated with TTD. We compared pregnancies resulting TTD-affected offspring (n = 24) respect...
Haemophilus influenzae (H. influenzae) and Moraxella catarrhalis (M. catarrhalis) are associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD); however, their role in the pathogenesis COPD is unknown. We retrospectively analysed clinical data patients AECOPD (modified British Medical Research Council scale score, Global Initiative for Chronic Obstructive Lung Disease [GOLD] classification, pre-admission antibiotic inhalant usage, sputum culture epidemic influenza...