A5006713800- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- earthquake and tectonic studies
- Cancer therapeutics and mechanisms
- Renal Diseases and Glomerulopathies
- Earthquake and Tsunami Effects
- Cancer Treatment and Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Trace Elements in Health
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- NF-κB Signaling Pathways
- Marine Sponges and Natural Products
- Glycosylation and Glycoproteins Research
- Chronic Kidney Disease and Diabetes
- Cancer-related Molecular Pathways
- Autoimmune Bullous Skin Diseases
- Biochemical and Molecular Research
- Seismology and Earthquake Studies
- Toxin Mechanisms and Immunotoxins
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- T-cell and Retrovirus Studies
Tohoku University
2023-2025
Nagoya University
2013-2024
Tokyo Medical University
2024
Tokyo University of Pharmacy and Life Sciences
2021
Kagoshima University
2005-2019
National Hospital Organization Kyushu Cancer Center
1979-2018
Mie University
2007-2016
Tokushima University
2010-2013
Molecular Oncology (United States)
2004-2008
Fujitsu (Japan)
2007-2008
Platelet-derived endothelial cell growth factor (PD-ECGF) is known to promote the development of new blood vessels, which are fundamental tumor and metastasis. We previously found that thymidine phosphorylase (dThdPase) PD-ECGF same protein.We retrospectively examined expression dThdPase in primary colorectal carcinomas, its association with angiogenesis clinicopathologic findings, prognostic value.Tissues were obtained from tumors 163 patients whose carcinomas completely removed by surgery....
The serine/threonine protein phosphatase (PP) 2A inhibitor, microcystin-LR, selectively induces liver damage and promotes hepatocarcinogenesis. It is thought that microcystin-LR affects hepatocellular viability mainly through inhibition of PP2A, partially PP1, and, in addition, by generation reactive oxygen species (ROS). However, the molecular basis selective balance between cell death survival remained unclear. We analyzed cytotoxicity low doses using HEK293 cells stably expressing human...
PURPOSE Thymidine phosphorylase (TP) is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and has angiogenic activity. We examined whether TP expression in renal carcinoma (RCC) associated with microvessel density as a marker of angiogenesis, clinicopathologic characteristics, outcome. PATIENTS AND METHODS The enzymatic activity were 18 RCCs 19 kidney tissues not grossly involved tumor from 24 patients 13 paired samples 11 unpaired by spectrophotometry immunoblotting....
The activity of thymidine phosphorylase (dThdPase) has been reported to increase in several types malignant tumors. Experimental evidence shown that dThdPase is identical platelet-derived endothelial cell growth factor, and angiogenic activity. We examined the expression investigate whether correlates with angiogenesis, clinicopathologic features prognosis patients human gastric carcinomas. Microvessels were assessed by immunostaining cells for factor VIII. counted microvessels tumors 158...
The overexpression of a cell-surface glycoprotein termed P-glycoprotein (P-gp) is frequently associated with multidrug resistance (MDR) in cell lines vitro. To evaluate the implications P-gp expression clinical drug-resistance, we examined fresh leukaemia cells from chronic myelogenous (CML) patients blast crisis. By using immunoblotting monoclonal antibody against P-gp, C219, showed that three CML crisis were negative at stage when these complete remission, and high levels times same had...
Abcb10, member 10 of the ABC transporter family, is reportedly a part complex in mitochondrial inner membrane with mitoferrin-1 (Slc25a37) and ferrochelatase (Fech) responsible for heme biosynthesis utero. However, it unclear whether loss Abcb10 causes pathological changes adult mice. Here, we show that Abcb10(-/-) mice lack erythropoiesis abilities die midgestation. Moreover, generated Abcb10(F/-); Mx1-Cre mice, hematopoietic cells deleted, which showed accumulation protoporphyrin IX...
Gemcitabine is widely used for pancreatic, lung, and bladder cancer. However, drug resistance against gemcitabine a large obstacle to effective chemotherapy. Nucleoside transporters, nucleoside nucleotide metabolic enzymes, efflux transporters have been reported be involved in resistance. Although most of the resistant factors are supposed related each other, it unclear how one factor can affect other one. In this study, we established gemcitabine-resistant pancreatic cancer cell lines....
Background: Several case reports have described the concurrence of chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN). The presence autoantibodies against podocyte antigens phospholipase A2 receptor (PLA2R) thrombospondin type 1 domain containing 7A (THSD7A) in MN suggests an autoimmune mechanism. Some CIDP patients also harbor paranodal proteins such as neurofascin 155 (NF155) contactin-1 (CNTN1). We investigated relationship between by assaying a...
BACKGROUND Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial factor (VEGF) thymidine phosphorylase (TP)/platelet-derived cell (PD-ECGF) are involved in increased angiogenic activity disease progression solid tumors. However, there no information regarding the association of these factors with clinicopathologic findings testicular germ tumors (GCTs). METHODS The authors examined expression VEGF TP as well microvessel density GCTs their findings. Expression were...
To investigate the possible involvement of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and/or other glutathione S-conjugate export pump (GS-X pump) family members on active efflux irinotecan [(7-ethyl-10-[4-(1-piperidino)-1-pipertidino)-1-piperidino]carb onylox y camptothecin (CPT-11)] and its metabolites, as well their contribution to acquisition resistance, we studied uptake CPT-11, metabolite SN-38, glucuronide conjugate (SN38-Glu) using membrane vesicles from...
We measured expression of the MDR1 gene (also known as PGY1 gene) in human gastrointestinal tract. messenger RNA (mRNA) levels were elevated 13 15 colorectal carcinoma specimens and six gastric specimens. Well-differentiated carcinomas contained significantly higher concentrations mRNA than moderately differentiated carcinomas. Similarly, poorly normal tissues adjacent to was similar that xenografts nude mice also investigated. Elevated seen only four 18 not any carcinoma. P-glycoprotein...
Human KB carcinoma cells were selected in four sequential steps for increasing resistance to colchicine and found be cross-resistant multiple drugs. Thioridazine, a phenothiazine calmodulin inhibitor, almost completely reversed the of multiple-drug-resistant doxorubicin, vinblastine, dactinomycin, daunorubicin, partially vincristine. Other inhibitors, trifluoperazine chlorpromazine, also show similar but somewhat weaker effects on drug resistance. However, well-known naphthalenesulfonamide...
STI571, an Abl‐specific tyrosine kinase inhibitor, selectively kills Bcr‐Abl‐containing cells in vitro and vivo . However, some chronic myelogenous leukemia (CML) cell lines are resistant to STI571. We evaluated whether STI571 interacts with P‐glycopro‐tein (P‐gp) multidrug resistance protein 1 (MRP1), examined the effect of agents that reverse (MDR) on SI571 MDR cells. inhibited [ 125 l]azidoagosterol A‐photolabeling P‐gp, but not MRP1. K562/MDR overexpress P‐gp were 3.67 times more than...