A5061766876- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal cell carcinoma treatment
- Renal Transplantation Outcomes and Treatments
- Cancer Immunotherapy and Biomarkers
- Motor Control and Adaptation
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Bladder and Urothelial Cancer Treatments
- Alcohol Consumption and Health Effects
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Muscle activation and electromyography studies
- Blood Pressure and Hypertension Studies
- Sleep and related disorders
- Dental Health and Care Utilization
- Cytomegalovirus and herpesvirus research
- Prostate Cancer Treatment and Research
- Cryospheric studies and observations
- Potassium and Related Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vasculitis and related conditions
- Sodium Intake and Health
Osaka University
2016-2025
Osaka University of Health and Sport Sciences
2025
Korea Health Promotion Institute
2024-2025
Counseling Center
2024-2025
Osaka Health Science University
2016-2025
Akita University
2015-2024
Kumamoto Health Science University
2022-2024
Molina Center for Energy and the Environment
2024
Fukushima Medical University
2024
Creative Commons
2023
Keap1 and Cul3 constitute a unique ubiquitin E3 ligase that degrades Nrf2, key activator of cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity this complex is inhibited fails degrade resulting in transcriptional activation Nrf2 target possesses several reactive cysteine residues covalently bond with electrophiles vitro. To clarify functional significance each residue under physiological conditions, we established transgenic complementation rescue model. The...
We recently used positional cloning to identify the transcription factor Nrf2 (NF-E2 related 2) as a susceptibility gene in murine model of oxidant-induced acute lung injury (ALI). NRF2 binds antioxidant response elements (ARE) and up-regulates protective detoxifying enzymes oxidative stress. This led us investigate candidate for risk development ALI humans. identified multiple single nucleotide polymorphisms (SNPs) by resequencing ethnically diverse subjects, one (-617 C/A) significantly...
The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; this study, we modified improve its variability and consistency. had lower among trials days than the young C57BL6 mice, especially by improving variabilities male. was more sensitive detect difference motor between female male or old mice. When performed on mice during aging process, reduction of manifested 18 24 months age at group level individual level. similar detecting...
Abstract D-Amino acids, the enantiomers of L-amino are increasingly recognized as novel biomarkers. Although amounts D-amino acids usually very trace in human, some them have sporadically been detected blood from patients with kidney diseases. This study examined whether multiple chiral amino would be associated functions, comorbidities, and prognosis chronic disease (CKD) by enantioselective analyses all a micro-two-dimensional high-performance liquid chromatograph (2D-HPLC)-based...
Abstract We sought to verify the reliability of machine learning (ML) in developing diabetes prediction models by utilizing big data. To this end, we compared gradient boosting decision tree (GBDT) and logistic regression (LR) using data obtained from Kokuho-database Osaka prefecture, Japan. develop models, focused on 16 predictors health checkup April 2013 December 2014. A total 277,651 eligible participants were studied. The developed a light (LightGBM), which is an effective GBDT...
Significance Statement Developing strategies for managing coronary artery calcification (CAC) in patients with CKD remains a clinical challenge. Previous experimental studies showed that magnesium inhibits vascular calcification, whereas the uremic toxin indoxyl sulfate aggravates it. In 2-year, open-label, randomized, controlled trial two-by-two factorial design, authors investigated whether oral oxide or carbon adsorbent AST-120 affected CAC progression stage 3−4 risk factors CAC. an...
Although multiple studies have identified skipping breakfast as a risk factor for weight gain, there is limited evidence on the clinical impact of lunch and dinner gain. This retrospective cohort study including 17,573 male 8860 female university students at national in Japan, assessed association frequency breakfast, lunch, with incidence gain (≥10%) overweight/obesity (body mass index ≥ 25 kg/m2), using annual participant health checkup data. Within observation period 3.0 ± 0.9 years, ≥10%...
The aim of this study was to investigate the relationship between preoperative patient factors and postoperative half-year health care utilization reflecting recovery, common complications, comorbidities, significant concerns, identifying strong risk protective factors. This retrospective cohort utilized linear, quantile, ordinal regressions analyze Osaka National Health Insurance data from 26 606 elderly patients who underwent hip fracture surgery 2012 2018. key associated with multiple...
Background and objectives Shorter or longer sleep duration poor quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, mortality in subjects with normal kidney function. The association of health outcomes patients CKD remains uncertain. Design, setting, participants, & measurements A 4-year prospective cohort study 17 nephrology centers Japan, the Japan Cohort (CKD-JAC) Study, assessed an self-reported quality, on basis Pittsburgh Sleep Quality Index...
Hypomagnesemia (Hypo-Mg) predicts mortality and chronic kidney disease (CKD) progression. However, in CKD, its prevalence, kidney-intrinsic risk factors, the effectiveness of oral magnesium (Mg) therapy on serum Mg levels is uncertain.In a cross-sectional study enrolling pre-dialysis outpatients with prevalence electrolyte abnormalities (Mg, sodium, potassium, calcium phosphorus) was compared. In an open-label randomized controlled trial (RCT), we randomly assigned CKD patients to either...
Key Points Restarting renin-angiotensin system inhibitor after discontinuation was associated with a lower risk of kidney outcomes and mortality but not related to hyperkalemia. Our findings support proactive approach restarting among patients CKD. Background While inhibitors (RASi) have been the mainstream treatment for CKD, they are often discontinued because adverse effects such as hyperkalemia AKI. It is unknown whether RASi improves clinical outcomes. Methods Using Osaka Consortium...
Nrf2-small Maf heterodimer activates the transcription of many cytoprotective genes through antioxidant response element and serves as a key factor in xenobiotic oxidative stress responses. Our surface plasmon resonance-microarray binding analysis revealed that both Nrf2-MafG MafG homodimer bind to consensus recognition with high affinity but differentially suboptimal sequences degenerated from consensus. We examined molecular basis distinguishing profile found Ala-502 residue basic region...
Hepcidin is a central regulator of iron homeostasis. Increased hepcidin concentrations could cause iron-restricted erythropoiesis in chronic kidney disease (CKD)-associated anemia. This cross-sectional observational study was conducted to evaluate the association between and CKD-associated anemia non-dialysis CKD patients. A total 505 patients not treated with parenteral were recruited, serum hepcidin-25 levels measured by liquid chromatography tandem mass spectrometry. Multiple linear...
Abstract A critical issue in the management of chronic kidney disease (CKD) is to prevent patients from progression end-stage (ESKD), however, there only limited number biomarkers for discrimination high-risk CKD patients. We aimed identify metabolites which possess ability predict earlier deterioration. performed capillary electrophoresis and liquid chromatography mass spectrometry (CE-MS)-based metabolic profiling a prospective cohort, consisted referred 112 with median follow-up period...
The Agatston score, commonly used to quantify coronary artery calcification (CAC), is determined by the plaque area and density. Despite an excellent predictability of score for cardiovascular events, density CAC has never been studied in patients with pre-dialysis chronic kidney disease (CKD). This study aimed analyze its association serum mineral levels CKD.We enrolled CKD who had diabetes mellitus, prior history, elevated low-density lipoprotein cholesterol levels, or smoking history....
Abstract Background Despite recent advances in immunosuppressive therapy for patients with primary nephrotic syndrome, its effectiveness and safety have not been fully studied nationwide real-world clinical data Japan. Methods A 5-year cohort study, the Japan Nephrotic Syndrome Cohort Study, enrolled 374 syndrome 55 hospitals Japan, including 155, 148, 38, 33 minimal change disease (MCD), membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), other glomerulonephritides,...
Small Maf transcription factors possess a basic region‐leucine zipper motif through which they form homodimers or heterodimers with CNC and Bach proteins. Different combinations of small CNC/Bach protein dimers bind to cis ‐acting DNA elements, collectively referred as Maf‐recognition elements (MAREs), either activate repress transcription. As MAREs defined by function are often divergent from the consensus sequence, we speculated that sequence variations in basis for selective Maf:Maf...
Population-based studies have reported outcomes and risk factors for patients with chronic kidney disease (CKD), defined primarily by decreased estimated GFR (eGFR). They are characterized old age, low proteinuria level, stage 3 CKD. However, many referred to nephrologists younger overt advanced This study evaluated the association between those among CKD patients.We retrospectively reviewed 461 5 from January 2003 December 2007. Key were death ESRD. Patients followed time of first serum...