A5000358315- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Diabetes Treatment and Management
- Acute Kidney Injury Research
- Systemic Sclerosis and Related Diseases
- Renal and Vascular Pathologies
- Hemodynamic Monitoring and Therapy
- Dialysis and Renal Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetes Management and Research
- Lysosomal Storage Disorders Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Connective Tissue Growth Factor Research
- Vasculitis and related conditions
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Muscle and Compartmental Disorders
- TGF-β signaling in diseases
- Monoclonal and Polyclonal Antibodies Research
Nara Medical University
2014-2023
Osaka University
2023
Nara Medical University Hospital
2007-2023
Research Network (United States)
2020
Rakuwakai Otowa Hospital
2012
National Archives and Records Administration
2012
University of Pennsylvania
2005
Nagasaki University
2002
GTx (United States)
2002
Miyazaki Welfare Medical College
1995
Hypoxia has been proposed as an important microenvironmental factor in the development of tissue fibrosis; however, underlying mechanisms are not well defined. To examine role hypoxia-inducible factor–1 (HIF-1), a key mediator cellular adaptation to hypoxia, fibrosis mice, we inactivated Hif-1α primary renal epithelial cells and proximal tubules kidneys subjected unilateral ureteral obstruction (UUO) using Cre-loxP–mediated gene targeting. We found that enhanced epithelial-to-mesenchymal...
CTGF plays a significant role in the development of renal fibrosis by mediating fibrotic effects transforming growth factor (TGF)-β 1 and has been shown to be hypoxia inducible human breast cancer cells. It suggested that is an important underlying cause for through modulation profibrotic genes. One key mediators cell's response lowered oxygen environments hypoxia-inducible-factor-1 (HIF-1), basic helix-loop-helix transcription factor, which enables cells adapt regulating expression genes...
Chronic hypoxia accelerates renal fibrosis. The chief mediator of the hypoxic response is hypoxia-inducible factor 1 (HIF-1) and its oxygen-sensitive component HIF-1α. HIF-1 regulates a wide variety genes, some which are closely associated with tissue To determine specific role in fibrosis, we generated knockout mouse tubular epithelial expression von Hippel-Lindau tumor suppressor (VHL), acts as ubiquitin ligase to promote proteolysis HIF-1α, was targeted. We investigated effect VHL...
Objective To investigate plasma concentrations of adrenomedullin in patients with septic shock and the potential association these relaxation vascular tone. Design Prospective, case series. Setting Department Emergency Critical Care Medicine, Nara Medical University. Patients Twelve who fulfilled clinical criteria for severe sepsis or (as defined by Members American College Chest Physicians/Society Medicine Consensus Conference Committee) 13 healthy volunteers. Interventions Arterial blood...
We measured the plasma levels of adrenomedullin (AM), a novel vasodilating peptide, in 89 patients with various forms systemic inflammatory response syndrome (SIRS) and 13 healthy volunteers serving as controls. Plasma AM SIRS (burns: 20.5 ± 3.2 fmol/ml [mean SEM]; pancreatitis: 13.8 3.8 fmol/ml; trauma: 14.9 2.5 traumatic shock: 41.1 7.8 severe sepsis: 59.9 11.2 septic 193.5 30.1 fmol/ml) were significantly increased over those controls (5.1 0.2 fmol/ml). The shock or especially had higher...
Our objective was to investigate the plasma levels of brain and atrial natriuretic peptides (BNP ANP, respectively) in patients with septic shock/severe sepsis study association BNP ANP hemodynamic parameters, severity disease, prognosis those patients. This is a prospective case series 22 shock, 11 severe sepsis, 20 healthy volunteers at Department Emergency Critical Care Medicine, Nara Medical University Hospital, Japan. Blood collection performed on admission days 1, 2, 4. Plasma were...
Abstract This retrospective cohort study examined the roles of inflammation in acute kidney injury (AKI). Serum albumin and C-reactive protein (CRP) were used as markers inflammation. Adults who underwent non–cardiac surgery from 2007 to 2011 included. Exclusion criteria urological surgery, obstetric missing data, pre-operative dialysis. Subjects followed until end 2015 or loss follow-up. Associations between pre–operative CRP post-operative AKI association mortality by logistic Cox...
Abstract Background Despite recent advances in immunosuppressive therapy for patients with primary nephrotic syndrome, its effectiveness and safety have not been fully studied nationwide real-world clinical data Japan. Methods A 5-year cohort study, the Japan Nephrotic Syndrome Cohort Study, enrolled 374 syndrome 55 hospitals Japan, including 155, 148, 38, 33 minimal change disease (MCD), membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), other glomerulonephritides,...
Introduction This study was conducted to investigate the incidence and time trend of lower limb amputation (LLA) among people with without diabetes. Research design methods retrospective population-based cohort based on national claims data in Japan, comprising a total population 150 million. Data all individuals who had LLA from April 2013 March 2018 were obtained. We analysed sex-adjusted age-adjusted annual rate (every fiscal year) diabetes for major minor amputation. To test trend,...
Renal dysfunction is commonly accompanied by a worsening of atherosclerosis; however, the underlying molecular mechanism not fully understood. We examined role played soluble fms-like tyrosine kinase-1 (sFlt-1), an endogenous antagonist proatherogenic cytokine placental growth factor (PlGF), in atherosclerosis patients with renal and animal model failure.In this study, 329 who received cardiac catheterization 76 underwent biopsy were enrolled. Both plasma sFlt-1 levels mRNA expression...
OBJECTIVE Type 2 diabetes accompanied by renal damage is a strong risk factor for atherosclerotic events. The purpose of this study was to investigate the efficacy low-dose aspirin therapy on primary prevention events in patients with type and coexisting dysfunction. RESEARCH DESIGN AND METHODS Japanese Primary Prevention Atherosclerosis With Aspirin Diabetes (JPAD) trial prospective, randomized, open-label conducted throughout Japan that enrolled 2,539 diabetic without history diseases....
Placental growth factor (PlGF) contributes to atherogenesis through vascular inflammation and plaque destabilization. High levels of PlGF may be associated with mortality cardiovascular disease, but the relationship between level adverse outcomes in patients CKD is unclear. We conducted a prospective cohort study 1351 consecutive participants enrolled Novel Assessment Risk management for Atherosclerotic diseases (NARA-CKD) April 1, 2004, December 31, 2011. During median follow-up 3 years,...
The accumulation of extracellular matrix in the glomeruli human and experimental models diabetic nephropathy is associated with disease progression. Transforming growth factor beta 1 (TGF-β1), which a multifunctional peptide factor, plays key role synthesis protein vitro, expression TGF-β1 elevated rat nephropathy. In this study, we measured urinary excretion 57 patients non-insulin-dependent diabetes mellitus 20 healthy volunteers to examine whether determination would facilitate evaluation...
We evaluated the significance of urinary IL-6 levels in prediction long-term renal outcome patients with IgA nephropathy (IgAN). Fifty-nine biopsy-proven IgAN were enrolled this study. All had a creatinine clearance (Ccr) greater than 80 ml/min and normal serum concentration (Scr) on enrollment followed for 8.07 +/- 1.72 years. Twenty- four-hour urine samples obtained was measured by ELISA. Fifteen exhibited worsening function (progressor). Renal remaining 44 stable during follow-up...
SUMMARY TGF-β1 is involved in the pathogenesis of glomerular sclerosis. We studied intraglomerular expression mRNA patients with glomerulonephritis using competitive polymerase chain reaction (PCR). This method sensitive enough to quantify cDNA copies present small amounts samples. Renal biopsy specimens were obtained from 42 various kinds glomerulonephritis. Ten glomeruli dissected renal specimens. Normal also resected kidneys eight cell cancer. Total RNA was extracted and reverse...