A5025519045- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Cerebral Venous Sinus Thrombosis
- Ear and Head Tumors
- Noise Effects and Management
- Facial Nerve Paralysis Treatment and Research
- Veterinary Equine Medical Research
- Meningioma and schwannoma management
- Cancer Cells and Metastasis
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Anomalies
- Glaucoma and retinal disorders
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Cancer Research and Treatments
- Oral and Maxillofacial Pathology
- Immune Response and Inflammation
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Planetary Science and Exploration
- Inflammatory mediators and NSAID effects
- Tracheal and airway disorders
University of Occupational and Environmental Health Japan
2008-2025
Kyoto Biken Laboratories (Japan)
2025
Iwate Medical University
2015-2024
Chiba University
2018-2024
Ohkawara Neurosurgical Hospital
2017-2024
Japan Racing Association
2001-2024
Okayama University
2002-2023
Nitto (Japan)
2022
Tokyo Institute of Technology
1983-2022
McGill University Health Centre
2022
Purpose: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a central role progression. We investigated whether CAFs can regulate tumor-infiltrating lymphocytes (TILs) and their immunosuppression.Experimental Design: A total of 140 cases esophageal cancer were analyzed for CD8+ or forkhead box protein 3 (FoxP3+) TILs by IHC. cytokines using murine human cells. Murine-derived cells also inoculated into BALB/c BALB/c-nu/nu mice tumors treated with recombinant IL6...
Four full-thickness skin wounds made in normal mice led to the significant increase levels of nerve growth factor (NGF) sera and wounded tissues. Since sialoadenectomy before inhibited rise serum NGF, NGF may be released from salivary gland into blood stream after wounds. In contrast, fact that messenger RNA protein were detected newly formed epithelial cells at edge wound fibroblasts consistent with granulation tissue produced space, suggests was also site. Topical application accelerated...
We investigated whether inflammatory biomarkers and stress are involved in the pathophysiology of idiopathic sensorineural hearing loss (ISHL).Individual cohort study.Two tertiary centers.Forty-three ISHL 10 non-ISHL patients seen our ENT departments from 2004 to 2010 within a week onset new symptoms without steroid administration before visiting departments.Multiple audiologic evaluations, blood tests including leukocyte counts, natural killer cell activity (NKCA), interleukin 6 (IL-6),...
Lymph node metastasis is a pathognomonic feature of spreading tumors, and overcoming challenge in attaining more favorable clinical outcomes. Esophageal cancer an aggressive tumor for which lymph strong poor prognostic factor, the microenvironment (TME), cancer-associated fibroblasts (CAFs) particular, has been implicated esophageal progression. CAFs play central role TME have reported to provide suitable conditions progression cancer, similar their other malignancies. However, little known...
Cancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs multifunctionality which strongly support cancer progression and acquisition of therapeutic resistance by cells. Near-infrared photoimmunotherapy (NIR-PIT) is a novel treatment that uses highly selective monoclonal antibody (mAb)-photosensitizer conjugate. We developed fibroblast activation protein (FAP)-targeted NIR-PIT, IR700 was conjugated to FAP-specific target (CAFs-targeted NIR-PIT:...
IgE hyperproduction frequently observed in patients with atopic dermatitis (AD) may greatly contribute to the pathogenesis of AD, but its mechanisms are still unclear. NC/Nga mice raised nonsterile circumstances spontaneously suffered from AD-like skin lesions elevation plasma levels. We investigated mice. Splenic T cells SPF had a level CD40 ligand (CD40L) expression comparable that BALB/c Although there was no difference on B between and mice, produced much more presence soluble CD40L...
Conclusion: An epidemiological survey of hospitals and private clinics in Japan regarding idiopathic sudden sensorineural hearing loss (SSNHL) revealed that the incidence SSNHL was 60.9 per 100 000 population. There were more females than males younger generation. Objective: The varies largely by country. Because Japanese criteria for diagnosing have changed accordance with those widely used other parts world, a clinicoepidemiological study undertaken using new criteria. Methods: Ehime,...
Using a large-scale nationwide survey database, we investigated the epidemiological characteristics for idiopathic SSNHL in Japan.The subjects this analysis were patients registered Japanese multicentre database between April 2014 and March 2016. A total of 3419 clinical obtained. Several factors associated with severity hearing impairment prognosis then investigated. Statistical was performed to clarify prognosis.There significant correlations loss diabetes mellitus, kidney disease, past...
Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment and play central role in progression. Previously, we reported that CAFs might induce immunosuppression via interleukin-6 (IL-6) promote progression by blocking local IL-6 with neutralizing antibody. Here, explore whether an anti-IL-6 receptor antibody could be used as systemic therapy to treat cancer, further investigate mechanisms which induces immunosuppression. In clinical samples, expression was...
The second-order nonlinear optical coefficients of 4H-SiC and 6H-SiC have been measured by use two second-harmonic generation methods, the rotational Maker-fringe wedge techniques, at fundamental wavelength 1.064 μm. Measurements on high-quality (0001) (112¯0) plane samples as well rigorous analyses taking into account multiple-reflection effects allowed us to accurately determine magnitudes coefficients. obtained values are d31=6.7 pm/V, d15=6.5 d33=−12.5 pm/V for 6H-SiC; d31=6.5 d15=6.7...
Objectives: Screening for MYO15A mutations was carried out using a large cohort to clarify the frequency and clinical characteristics of patients with (DFNB3) in hearing loss population. Methods: Genetic analysis 63 previously reported deafness genes based on massively parallel DNA sequencing (MPS) 1120 Japanese from 53 otorhinolaryngology departments performed. Detailed features were then collected analyzed. Results: Eleven 10 families found have compound heterozygosity MYO15A. Audiograms...
Objectives: The aim of this study was to investigate the differences between idiopathic sudden sensorineural hearing loss (SSNHL), and acute low-tone (ALHL) using results a nationwide survey database in Japan analyze variables associated with their clinical features severity impairment, treatment, prognosis.Methods: Participants were patients registered April 2014 March 2016 multicenter epidemiological involving 30 university hospitals medical centers across Japan. Statistical analysis...
Chondrodysplastic dwarfism in Japanese brown cattle is an autosomal recessive disorder characterized by short limbs. Previously, we mapped the locus responsible for disease on distal end of bovine chromosome 6. Here, narrowed critical region to ≈2 cM using linkage analysis, constructed a BAC and YAC contig covering this region, identified gene, LIMBIN ( LBN ), that possessed disease-specific mutations affected calves. One mutation was single nucleotide substitution leading activation cryptic...
Matrix metalloproteinase (MMP)-9 and tissue inhibitors of (TIMP)-1 concentrations are increased in the sputum asthma chronic bronchitis patients, thought to be related airflow obstruction. However, serum these enzymes have not been clearly evaluated patients with obstructive pulmonary disease (COPD). The aim this study was examine COPD asthmatic order determine their relationship airway Serum samples were obtained from 72 COPD: 66 control subjects 26 asthma. Smoking histories matched those...
We reviewed 165 cases of traumatic tympanic membrane perforation treated in the last 9 years (2000-2008). Of these, 103 sustained direct injury and 62 indirect injury. Ear picking accounted for 90.3% injuries. Perforation size followed classification Yoshikawa, with Grade I most common, according 129 (78.2%). The anteroinferior quadrant site was 98 (59.4%). 165, 66 were lost during followup. remaining 99, perforations closed spontaneously 85 (85.9%), within a mean 25.9 days. Tympanoplasty...
Usher syndrome is an autosomal recessive disorder manifesting hearing loss, retinitis pigmentosa and vestibular dysfunction, having three clinical subtypes. type 1 the most severe subtype due to its profound lack of responses, that appears in prepuberty. Six corresponding genes have been identified, making early diagnosis through DNA testing possible, with many immediate several long-term advantages for patients their families. However, conventional genetic techniques, such as direct...
Abstract Cancer-associated fibroblasts (CAFs) play a significant role in tumor progression within the microenvironment. Previously, we used near-infrared photoimmunotherapy (NIR-PIT), next-generation cancer cell-targeted phototherapy, to establish CAF-targeted NIR-PIT. In this study, investigated whether dual-targeted NIR-PIT, targeting cells and CAFs, could be therapeutic strategy. A total of 132 cases esophageal were analyzed for epidermal growth factor receptor (EGFR), human 2 (HER2),...
Using a computer‐aided three‐dimensional reconstruction and measurement method, 12 measurements were made to determine the dimensions of maculae, cristae ampullares, semicircular canals in 18 temporal bones from nine pairs age‐matched male female individuals (1 day 76 years old). The surface areas utricular saccular maculae significantly larger than specimens (two‐way analysis variance, F = 9.00, df 1, p<0.01; 4.57, p < 0.05, respectively). width macula length also greater 5.17, 0.05;...
Abstract Background Mucosal melanoma of the head and neck is rare associated with a poor prognoses because locoregional failure distant metastasis. The aim our study was to review characteristics these patients in northern Japan analyze their outcomes. Methods medical records 94 who had been provided initial treatment 12 institutes from 1998 2007 were reviewed. Results When 5‐year overall survival rates evaluated, we found that treated by chemotherapy significantly lower than those surgery...