A5006192040- Head and Neck Cancer Studies
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Sinusitis and nasal conditions
- Tumors and Oncological Cases
- Ear Surgery and Otitis Media
- Cardiac tumors and thrombi
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Facial Nerve Paralysis Treatment and Research
- Vascular Tumors and Angiosarcomas
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
Iwate Medical University
2016-2025
National Institute of Advanced Industrial Science and Technology
2024
Iwate University
2023
Showa University Koto Toyosu Hospital
2022
Showa University
2022
Kyoto Prefectural University of Medicine
1990-2017
Tohoku University
2003-2016
Miyagi Prefectural Hospital Organization
1997-2015
Tohoku University Hospital
2006-2012
Nanjing University
2005
Administration of poly(ADP-ribose) synthetase inhibitors such as nicotinamide to 90% depancreatized rats induces regeneration pancreatic islets, thereby ameliorating the surgical diabetes (Yonemura, Y.,
PURPOSE The standard treatment for postoperative high-risk locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) is chemoradiotherapy with 3-weekly cisplatin (100 mg/m 2 ). However, whether weekly (40 ) yields comparable efficacy in LA-SCCHN unknown. PATIENTS AND METHODS In this multi-institutional open-label phase II/III trial, patients were randomly assigned to receive either or confirm noninferiority cisplatin. primary end point II was proportion completion, that III...
Background. Many studies have reported the increased expression of epidermal growth factor receptor (EGFR) in various human malignancies and its association with biologic behavior tumors. Methods. We performed an immunohistochemical analysis EGFR 217 cases esophageal squamous cell carcinoma, 161 lymph node metastases 23 foci dysplasias. The findings were correlated clinicopathologic features, including clinical outcome. Southern blot was 42 for detection DNA amplification gene subsequently...
Integrated hepatitis B virus (HBV) DNA is found in hepatocellular carcinomas which develop HBV carriers. Presented here are the results of analyses four integrants that show chromosomal rearrangements associated with integrated DNA. Two clones (p4 and C15) were to have large inverted repeating structures, each consisting genome along flanking cellular sequences. The structure must arisen by duplication primary integrant, including DNA, followed recombination within viral One two arms clone...
It has been suggested that Helicobacter pylori (H. pylori) infection might be associated with not only gastric ulcers but also malignancies. Recently, it was reported the Streptococcus anginosus (S. anginosus) DNA sequence found in samples extracted from esophageal cancers. Because smoking and alcohol abuse are regarded as risk factors for both esophgeal cancer head neck cancer, of S. carcinogenesis cancer. To investgate involvement we analyzed 217 prepared squamous cell carcinomas. We...
Anti-EGFR therapy is among the most promising molecular targeted therapies against cancer developed in past decade. However, drug resistance eventually arises most, if not all, treated patients. Emerging evidence has linked epigenetic changes, such as DNA methylation at CpG islands, to development of multiple anticancer drugs. In addition, genes that are differentially methylated have increasingly been appreciated a source clinically relevant biomarker candidates. To identify specifically...
We have found previously that human plasma-membrane-associated sialidase (NEU3), a key glycosidase for ganglioside degradation, was markedly up-regulated in colon cancers, with an involvement suppression of apoptosis. To elucidate the molecular mechanisms underlying increased NEU3 expression, present study we investigated its role cell adhesion cancer cells. DLD-1 cells transfected exhibited to laminins and consequent proliferation, but decreased fibronectin collagens I IV, compared control...
We sought to characterize the effectiveness of concomitant chemoradiotherapy (CCRT) for patients with squamous cell carcinoma temporal bone. performed a retrospective chart review 14 cancer bone who were provided initial treatment in our hospital from December 2001 November 2008. Four stage I tumors treated by radiation therapy alone or oral administration S1. One patient II tumor was low dose docetaxel. Nine IV CCRT using TPF regimen (docetaxel, cisplatin, and 5-fluorouracil). As an...
Objective: This study evaluated the sensitivity and accuracy of ultra‐high‐resolution computed tomography (U‐HRCT) in predicting relationship between chorda tympani long crus incus patients with otosclerosis or middle ear anomalies. Methods: Thirteen anomalies were enrolled this (three males ten females; mean age, 41.6 years; range, 7–67 years). The underwent U‐HRCT (Aquilion Precision; Canon Medical Systems, Japan). Multiplanar reconstruction images obtained, distance was measured a plane...
Objective We sought to assess the efficacy of combined therapy after superselective arterial cisplatin infusion (SACI) treat maxillary squamous cell carcinoma. Study Design conducted a retrospective chart review 50 patients. After completion two courses SACI, 25 patients were successively treated by concurrent SACI and radiotherapy (AR), while other surgery with postoperative (ASR). Results Patients (ASR) had an 88% local control rate 75% disease‐free survival at 60 months Kaplan‐Meier...
Abstract Background Mucosal melanoma of the head and neck is rare associated with a poor prognoses because locoregional failure distant metastasis. The aim our study was to review characteristics these patients in northern Japan analyze their outcomes. Methods medical records 94 who had been provided initial treatment 12 institutes from 1998 2007 were reviewed. Results When 5‐year overall survival rates evaluated, we found that treated by chemotherapy significantly lower than those surgery...
Regional lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) is a crucial event for its progression, associated with high rate of mortality. Sialidase, key enzyme the regulation cellular sialic acids through catalyzing initial step degradation glycoproteins glycolipids, has been implicated cancer progression. To facilitate development novel treatments HNSCC, we have investigated whether sialidase involved progression this cancer. We found plasma membrane-associated (NEU3)...
The role of lenvatinib as neoadjuvant chemotherapy for patients with advanced thyroid cancer has not been firmly established. In some cases, surgery may be considered when treatment becomes challenging to continue.
For the purpose of analyzing mechanisms related to cis ‐diamminedichloroplatinum resistance in head and neck squamous cell carcinoma, we analyzed RPMI 2650 its derived previously established resistant line CR . To identify phenotype‐related micro RNA s, compared expressions between by microarray. One s as downregulated, mi R ‐34a, was further investigated. Decreased expression ‐34a confirmed quantitative reverse transcription‐polymerase chain reaction, but introduction precursor into or...
There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed CBT throughout Japan by gathering information on these from institutions that performed head and neck surgeries. Information a total 150 25 past 20 years was employed present survey. were 87 females 63 males, their mean age 48.0 old. The most common chief complaint mass suffering period 46.1 months. Eighteen had family history paragangliomas fifteen...
Abstract Background Here, we report the results of Japanese subgroup phase 3 KEYNOTE-048 study pembrolizumab alone, plus platinum and 5-fluorouracil (pembrolizumab–chemotherapy), or cetuximab (EXTREME) in previously untreated recurrent/metastatic (R/M) head neck squamous cell carcinoma (HNSCC). Methods Primary end points were overall survival (OS) progression-free (PFS). Efficacy was evaluated patients with PD-L1 combined positive score (CPS) ≥ 20 1 total ( n = 67). Results At data cutoff...