A5045166286- Hearing Loss and Rehabilitation
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Acoustic Wave Phenomena Research
- Lung Cancer Treatments and Mutations
- nanoparticles nucleation surface interactions
- Noise Effects and Management
- Quantum chaos and dynamical systems
- Speech and Audio Processing
- Lung Cancer Research Studies
- Spectroscopy and Quantum Chemical Studies
- Epigenetics and DNA Methylation
- Advanced Thermodynamics and Statistical Mechanics
- RNA modifications and cancer
- Material Dynamics and Properties
- Chemotherapy-induced organ toxicity mitigation
- Salivary Gland Tumors Diagnosis and Treatment
- Music Technology and Sound Studies
- Head and Neck Surgical Oncology
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Advanced Chemical Physics Studies
- Colorectal and Anal Carcinomas
- Theoretical and Computational Physics
- Neuroendocrine Tumor Research Advances
Hokkaido University
2016-2025
Sapporo Medical University
2014-2025
Hokkaido University Hospital
1984-2025
Daido University
2010-2022
Tokyo Medical and Dental University
2020
East Japan Railway (Japan)
2020
Weatherford College
2020
Ritsumeikan University
2002-2019
Abu Dhabi National Oil (United Arab Emirates)
2018
Creative Research Enterprises (United States)
2016
To assess efficacy and safety of nivolumab versus investigator's choice therapy (IC) in Asian patients with platinum-refractory recurrent or metastatic squamous cell carcinoma the head neck (SCCHN). Thirty-four from Japan, Taiwan, Hong Kong, Korea received 3 mg/kg (n = 23) every 2 weeks IC 11), as part a global trial 361), until intolerable toxicity disease progression. The primary endpoint was overall survival (OS). Median OS 9.5 months (95% confidence interval [CI] 9.1–NR) 6.2 CI 2.6–NR)...
The polycomb group genes Bmi1 ring finger oncogene (Bmi1) and enhancer of zeste homolog 2 (EZH2) function as transcriptional repressors involved in gene silencing the malignant transformation biologic aggressiveness several human carcinomas. In current study, authors evaluated EZH2 protein expression specimens nonsmall cell lung cancer (NSCLC).The conducted an immunohistochemical assessment 157 surgically resected NSCLCs to evaluate correlation between various features, including clinical,...
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<b><i>Objecitive:</i></b> Fucosyltransferase 8 (FUT8), the only enzyme responsible for core α1,6-fucosylation of asparagine-linked oligosaccharides glycoproteins, is a vital in cancer development and progression. We examined FUT8 expression non-small cell lung cancers (NSCLCs) to analyze its clinical significance. also guanosine diphosphate-mannose-4,6-dehydratase (GMD), which imperative synthesis fucosylated oligosaccharides....
Recent discoveries have revealed that human cancer involves aberrant epigenetic alterations. We and others previously shown the histone methyltransferase EZH 2, catalytic subunit of polycomb repressive complex 2 ( PRC 2), is frequently overexpressed in non‐small‐cell lung NSCLC ) an inhibitor, 3‐deazaneplanocin A, inhibits proliferation cells. Transcriptional silencing by was recently to be required for activity deacetylases HDAC s) interact with another protein, EED . To develop a more...
Abstract Background To fill the data gap between clinical trials and real-world settings, this study assessed overall effectiveness safety of nivolumab in patients with head neck cancer (HNC) during Japanese practice. Methods This was a multicenter, retrospective recurrent or metastatic HNC who received for first time July December 2017. Data on use, effectiveness, were extracted from patient medical records. Results Overall, 256 enrolled study. The median duration treatment 72.5 days,...
Abstract Background The present study evaluated the 2‐year survival of Asian population in CheckMate 141 trial. Methods trial included patients with recurrent or metastatic (R/M) squamous cell carcinoma head and neck (SCCHN). In study, 34 (nivolumab group: 23 patients; investigator's choice therapy [IC] 11 patients) were analyzed. Results median overall (OS) was 12.1 6.2 months for nivolumab IC groups, respectively. estimated OS rates 22.7% 0% group, any treatment‐related adverse events...
Precision medicine plays an important role in the treatment of patients with advanced melanoma. Despite its high incidence White patients, melanoma is rare Asian countries, hampering prospective clinical trials targeting population. This retrospective study aimed to elucidate real-world molecular diagnoses and outcomes Japanese using comprehensive genome profiling (CGP). Patients who completed standard anticancer medical treatments (including those expected complete treatments) underwent...
An improved statistical-acoustics model of high-frequency sound fields in coupled rooms is developed by incorporating into prior models geometrical-acoustics corrections for both energy decay within subrooms and transfer between subrooms. The conditions under which are valid approximations to geometrical acoustics examined comparison computational predictions curves two- three-room systems with those models. accuracy the used found have a primary influence on systems. Likewise, nondiffuse...
An extensive numerical study of level-spacing properties rational and irrational polygonal billiard systems is carried out. It found that level statistics both billiards deviate from a Gaussian-orthogonal-ensemble-type fluctuation. also explored in detail whether the with infinite genus number provide different characteristics those finite number. Some delicate problems dealing several types pseudointegrable are discussed.
The ability of computational geometrical acoustics to accurately model energy decay in systems coupled rooms is investigated both theoretically and experimentally. Unlike single-volume rooms, have reflection density that not described by a single quadratic function time. It shown tail-correction procedures used beam-axis-tracing algorithms, which assume growth density, can lead inaccurate predictions rooms. Further, beam-axis tracing implemented as ray with growing detection sphere...
Abstract Background Induction chemotherapy (IC) in locally advanced squamous cell carcinoma of the head and neck (LA‐SCCHN) often compromises compliance with subsequent chemoradiotherapy (CRT), which negatively affects outcomes. Here, we assessed combination paclitaxel (PTX), carboplatin (CBDCA), cetuximab (Cmab) as IC for unresectable LA‐SCCHN. Methods consisted weekly CBDCA area under plasma concentration‐time curve = 1.5, PTX 80 mg/m 2 Cmab an initial dose 400 followed by 250 8 weeks....
Abstract Background Platinum and anti-PD-1 antibodies are the front-line systemic therapy for recurrent or metastatic head neck squamous cell carcinoma (RM-HNSCC). However, limited data available on clinical outcomes appropriate regimens patients with RM-HNSCC following treatment failure these agents. Patients methods We retrospectively analyzed of from 10 Japanese institutions in whom platinum nivolumab failed. Results Of 480 included study, 236 were treated best supportive care had a...
Abstract E1AF/PEA3, an Ets family transcription factor, is frequently overexpressed in non–small-cell lung cancers (NSCLCs). Overexpression of E1AF increases motility and invasion VMRC-LCD NCI-H226 NSCLC cells, which lack endogenous expression, the effect synergistically increased by hepatocyte growth factor (HGF). The small GTPase Rho/Rho-associated kinase (ROCK) pathway also involved invasion. To determine role Rho/ROCK malignant phenotypes induced E1AF, we analyzed cells transfected with...
Abstract Background Here, we report the results of Japanese subgroup phase 3 KEYNOTE-048 study pembrolizumab alone, plus platinum and 5-fluorouracil (pembrolizumab–chemotherapy), or cetuximab (EXTREME) in previously untreated recurrent/metastatic (R/M) head neck squamous cell carcinoma (HNSCC). Methods Primary end points were overall survival (OS) progression-free (PFS). Efficacy was evaluated patients with PD-L1 combined positive score (CPS) ≥ 20 1 total ( n = 67). Results At data cutoff...
cJun, a major constituent of AP-1 transcription factor transducing multiple mitogen growth signals, is frequently overexpressed in non-small cell lung cancers (NSCLCs). The purpose this study to determine the effects blockade on NSCLC cells using cJun dominant-negative mutant, TAM67. Transiently transfected TAM67 inhibited transcriptional activity lines, NCI-H1299 (H1299), A549 and NCI-H520 (H520). colony-forming efficiency H1299 was reduced by TAM67, while that H520 not. To elucidate H1299,...