A5080208801- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Genomics and Rare Diseases
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Neutropenia and Cancer Infections
- Brain Metastases and Treatment
- Pancreatitis Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Economic and Financial Impacts of Cancer
- Multiple and Secondary Primary Cancers
- Neuroblastoma Research and Treatments
Hokkaido University Hospital
2016-2025
Hokkaido University
2007-2020
Sapporo Medical University
2012-2020
Daido University
2018
Misawa City Hospital
2005
Ikeda Municipal Hospital
2004
Health First
2002
Abstract Background To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, Clinical and Cancer Association, jointly published “Clinical practice guidance for next-generation sequencing cancer diagnosis treatment” 2017. Since new information on genomic medicine has emerged since 1st edition was released, including reimbursement NGS-based multiplex gene panel tests 2019, revision made. Methods A working group organized with 33 researchers from designated...
Abstract Background Since June 2019, cancer genomic profiling (CGP) tests have been reimbursed by the National Health Insurance system in Japan, with restrictions for government-designated hospitals a molecular tumor board composed of multidisciplinary specialists, known as an expert panel (EP). The standardization EPs is critical challenge implementing precision oncology clinical setting. Methods Data on consecutive cases who underwent CGP at 11 core between 2019 and January 2020 were...
In Japan, comprehensive genomic profiling (CGP) tests for refractory cancer patients have been approved since June 2019, under the requirement that all cases undergoing CGP are annotated by molecular tumor board (MTB) at each government-designated hospital. To investigate improvement in precision oncology, we evaluated and compared proportion of receiving matched treatments according to results those recommended receive genetic counseling core hospitals between first period (11 hospitals,...
Heart failure (HF) causes organ congestion, which is thought to increase stiffness. The virtual touch quantification (VTQ) method can be used assess liver stiffness in patients with chronic diseases. This study aimed measure and kidney using VTQ determine its value for assessing congestion HF.This included 10 normal subjects 38 HF (age 52.3±16.7 years, left ventricular ejection fraction 27.0±9.4%, plasma B-type natriuretic peptide [BNP] 1,297.3±1,155.1 pg/ml). We investigated the...
Abstract Precision medicine is a promising strategy for cancer treatment. In this study, we developed an in‐house clinical sequencing system to perform comprehensive genomic profiling test as examination and analyzed the utility of system. Genomic DNA was extracted from tumor tissues peripheral blood cells collected 161 patients with different stages types cancer. A targeted amplicon exome 160 cancer‐related genes performed using next‐generation (NGS). The data were original bioinformatics...
Substantial heterogeneity exists in treatment recommendations across molecular tumor boards (MTBs), especially for biomarkers with low evidence levels; therefore, the learning program is essential.
Precision medicine plays an important role in the treatment of patients with advanced melanoma. Despite its high incidence White patients, melanoma is rare Asian countries, hampering prospective clinical trials targeting population. This retrospective study aimed to elucidate real-world molecular diagnoses and outcomes Japanese using comprehensive genome profiling (CGP). Patients who completed standard anticancer medical treatments (including those expected complete treatments) underwent...
Tumour budding is a risk factor for poor prognosis in various cancers. buds may present an epithelial-mesenchymal transition (EMT) morphological phenotype. This study aimed to elucidate the prognostic impact of tumour grade and its association with clinicopathological EMT-related features perihilar cholangiocarcinoma (PHCC) or distal (DCC).Subjects included 195 PHCC 115 DCC patients. The numbers different patients were stratified postoperative survival using recursive partitioning technique....
Background/Aims: Delayed bleeding is among the adverse events associated with therapeutic gastrointestinal endoscopy. The aim of this study was to evaluate risk factors for delayed after endoscopic resection in patients receiving oral anticoagulants as well compare rates occurrence between used. Methods: We retrospectively analyzed a total 772 anticoagulants. Of these, 389 and 383 were direct (DOACs) warfarin, respectively. Therapeutic procedures performed included submucosal dissection...
Comprehensive cancer genomic profiling has been used recently for patients with advanced solid cancers. Two tests no standard treatment are covered by Japanese public health insurance since June 2019.We prospectively analyzed data of 189 cancers who underwent either the two-cancer at Hokkaido University Hospital and its liaison hospitals whose results were discussed in molecular tumor board between August 2019 July 2020.All had appropriate results. Actionable gene alterations identified 93...
Importance Quality assurance of molecular tumor boards (MTBs) is crucial in cancer genome medicine. Objective To evaluate the concordance recommendations by MTBs and centrally developed consensus treatment at all 12 leading institutions for genomic medicine Japan using 50 simulated cases. Design, Setting, Participants This was a prospective quality improvement study Molecular from core hospitals independently recommended cases blinded to recommendations. The study’s central committee...
Abstract Background The role of antithrombotic chemoprophylaxis in prevention venous thromboembolism (VTE) laparoscopic surgery for gastric and colorectal malignancies is unknown. This study compared the addition enoxaparin following intermittent pneumatic compression (IPC) with IPC alone patients undergoing gastrointestinal malignancy. Methods In this multicentre RCT, eligible were older than 40 years had a WHO performance status 0 or 1. Exclusion criteria prescription antiplatelet...
Abstract Comprehensive genomic profiling (CGP) tests have been covered by public insurance in Japan for patients with advanced solid tumors who completed or are completing standard treatments do not them. Therefore, genotype‐matched drug candidates often unapproved off‐label, and improving clinical trial access is critical, involving the appropriate timing of CGP tests. To address this issue, we analyzed previous treatment data 441 from an observational study on discussed expert panel at...
The herbal medicine rikkunshito has the potential to improve chemotherapy-induced nausea and vomiting (CINV) by stimulating ghrelin secretion. We aimed evaluate efficacy safety of in preventing CINV for patients with lung cancer. Two separate prospective, randomized, phase II parallel design studies were conducted Fifty-eight 62 scheduled receive highly emetogenic chemotherapy (HEC) moderately (MEC), respectively, randomized 1:1 either standard antiemetic therapy accordance international...
Obstructive jaundice has been reported to influence liver elasticity, independent of fibrosis. The aim our prospective study was evaluate the changes in before and after biliary drainage, patients with obstructive jaundice, correlation between elasticity measures serum markers fibrosis.This is a cohort 20 jaundice. Liver assessed by Transient Elastography (TE) Virtual Touch™ Quantification (VTQ). Serum total bilirubin (T-Bil) level measured drainage (Day 0), repeated at 2 days 2) 7 7)...