A5045468227- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Platelet Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Viral-associated cancers and disorders
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
Kindai University
2016-2025
Kindai University Hospital
2015-2024
Kanazawa University Hospital
2022
NTT Medical Center
2022
National Hospital Organization Kyushu Cancer Center
2022
Sapporo Hokuyu Hospital
2022
Tosei General Hospital
2022
Saitama Medical University
2022
Tokyo Medical and Dental University
2022
Kanazawa University
2022
Significance In BCP ALL, molecular classification is used for risk stratification and influences treatment strategies. We reanalyzed the transcriptomic landscape of 1,223 ALLs identified 14 subgroups based on their transcriptional profiles. Eight these (G1 to G8) are previously well-known subgroups, harboring specific genetic abnormalities. The sample size allowed identification six undescribed consisting cases PAX5 or CRLF2 fusions (G9), (p.P80R) mutations (G10), IKZF1 (p.N159Y) (G11),...
Although thrombopoietin (TPO) is known to play a fundamental role in both megakaryopoiesis and thrombopoiesis, the molecular mechanism of TPO-induced megakaryocytic differentiation not known. In human megakaryoblastic leukemia cell line, CMK, that showed some degree after culture with TPO, cyclin-dependent kinase (Cdk) inhibitor p21WAF1/Cip1, but p27Kip1, p16INK4A, p15INK4B, or p18INK4C, was found be upregulated an immediately early response TPO. The expression p21 sustained over period 5...
Key Points KIT exon 17 mutation is a poor prognostic factor in AML patients with RUNX1-RUNX1T1, but not those CBFB-MYH11. NRAS
Abstract Background To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, Clinical and Cancer Association, jointly published “Clinical practice guidance for next-generation sequencing cancer diagnosis treatment” 2017. Since new information on genomic medicine has emerged since 1st edition was released, including reimbursement NGS-based multiplex gene panel tests 2019, revision made. Methods A working group organized with 33 researchers from designated...
Cell cycle machinery controls not only cell growth but also survival and death. For example, overexpression of c-Myc or E2F1, which are involved in G1/S transition, causes apoptosis under certain conditions. Furthermore, endogenous E2F1 participates apoptosis, as evidenced by the defect E2F1-deficient mice. Candidate molecules that mediate c-Myc- E2F1-enhanced include p14/p19ARF, ornithine decarboxylase lactate dehydrogenase-A (for c-Myc) well p73, Apaf-1 caspase-3 E2F1). activates...
Notch and HOXB4 have been reported to expand hematopoietic stem cells (HSCs) in vitro. However, their critical effector molecules remain undetermined. We found that the expression of c-myc, cyclin D2, D3, E, E2F1 was induced or enhanced during Notch1- HOXB4-induced self-renewal murine HSCs. Since c-Myc can act as a primary regulator G1/S transition, we examined whether alone induce In culture with cell factor, FLT3 ligand, IL-6, 4-hydroxytamoxifen-inducible form (Myc/ERT) enabled Lin–Sca-1+...
Interleukin (IL)-10, a cytokine with anti-inflammatory effects, is produced by blood cells and of various organs. Ischemia-reperfusion injury (IRI) systemic inflammatory disease caused circulation pro-inflammatory cytokines chemokines from or organs damaged ischemia. Apoptosis, key event after IRI, correlated the degree injury. Here we investigated effects mechanism IL-10 in renal IRI. Compared to wild-type (WT) mice knockout (IL-10 KO) IRI demonstrated decreased function as represented urea...
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of progenitors, known to be a heterogeneous disease in pediatric and adult patients. Here we attempted better understand the at molecular level based on transcriptomic landscape 707 T-ALL patients (510 pediatric, 190 patients, 7 with unknown age; 599 from published cohorts 108 newly investigated). Leveraging information gene expression enabled us identify 10 subtypes (G1–G10), including previously...
Many growth factors and cytokines prevent apoptosis. Using an expression cloning method, we identified a novel antiapoptotic molecule named Anamorsin, which does not show any homology to known apoptosis regulatory molecules such as Bcl-2 family, caspase or signal transduction molecules. The of Anamorsin was completely dependent on stimulation with interleukin 3, stem cell factor, thrombopoietin in factor-dependent hematopoietic lines, forced conferred resistance caused by factor deprivation...