A5060126327- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Mast cells and histamine
- CAR-T cell therapy research
- Vector-Borne Animal Diseases
National Kyushu Medical Center
2016-2025
The University of Tokyo
2023-2024
Kyushu University Hospital
2012-2024
Clinical Research Institute
2019-2023
Tachikawa Medical Center
2023
Sendai Medical Center
2023
Nagoya Medical Center
2023
Kurume University
2023
Kyushu University Beppu Hospital
2023
Nagoya City University
2022
Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. However, the specific BCL-2 family member(s) that regulate HSC homeostasis are not precisely defined. We tested myeloid leukemia-1 (MCL-1) as an attractive candidate highly expressed HSCs and regulated by growth factor signals. Inducible deletion of Mcl-1 mice resulted ablation bone marrow. This loss early marrow progenitor populations, including HSCs. Moreover, factors increased transcription gene required MCL-1 to...
The t(8;21) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML). translocation, which involves AML1 gene on chromosome 21 and ETO 8, generates an AML1-ETO fusion transcription factor. To examine effect protein leukemogenesis, we made transgenic mice in expression under control human MRP8 promoter (hMRP8-AML1-ETO). specifically expressed cells, including common progenitors hMRP8-AML1-ETO mice. were healthy during their life spans, suggesting that...
Basophils and mast cells, which are selectively endowed with the high-affinity IgE receptor mediate a range of adaptive innate immune responses, have an unknown developmental relationship. Here, by evaluating expression β7 integrin, molecule that is required for selective homing cell progenitors (MCPs) to periphery, we identified bipotent capable differentiating into either type in mouse spleen. These basophil/mast (BMCPs) gave rise basophils cells at single-cell level reconstituted both...
The mechanism of lineage specification in multipotent stem cells has not been fully understood. We recently isolated progenitors with the eosinophil, basophil, or mast cell potential, all which originate from granulocyte/monocyte (GMPs). By using these prospectively purified progenitors, we show here that expression timing GATA-2 and CCAAT enhancer-binding protein alpha (C/EBPalpha) can differentially control their commitment. instructed C/EBPalpha-expressing GMPs to commit exclusively into...
Eosinophil lineage–committed progenitors (EoPs) are phenotypically isolatable in the steady-state murine bone marrow. Purified granulocyte/monocyte (GMPs) gave rise to eosinophils as well neutrophils and monocytes at single cell level. Within short-term culture of GMPs, eosinophil potential was found exclusively cells activating transgenic reporter for GATA-1, a transcription factor capable instructing lineage commitment. These GATA-1–activating possessed an IL-5Rα+CD34+c-Kitlo phenotype....