A5049739608- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Retinoids in leukemia and cellular processes
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Acute Kidney Injury Research
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Toxin Mechanisms and Immunotoxins
- Galectins and Cancer Biology
- Inflammatory Myopathies and Dermatomyositis
- Bone health and treatments
- Immune Response and Inflammation
- Muscle and Compartmental Disorders
- Chemotherapy-induced organ toxicity mitigation
- Ocular Diseases and Behçet’s Syndrome
- Atherosclerosis and Cardiovascular Diseases
Kindai University
2016-2025
Fukushima Medical University
2023
Fukushima University
2022
Star General Hospital
2018
Monash University
2011
Monash Medical Centre
2011
Oki Electric Industry (Japan)
2000
Nagoya University
1999
National Institute of Infectious Diseases
1996
National Institute of Technology, Kumamoto College
1996
Interleukin (IL)-10, a cytokine with anti-inflammatory effects, is produced by blood cells and of various organs. Ischemia-reperfusion injury (IRI) systemic inflammatory disease caused circulation pro-inflammatory cytokines chemokines from or organs damaged ischemia. Apoptosis, key event after IRI, correlated the degree injury. Here we investigated effects mechanism IL-10 in renal IRI. Compared to wild-type (WT) mice knockout (IL-10 KO) IRI demonstrated decreased function as represented urea...
Leukocyte recruitment contributes to acute kidney injury (AKI), but the mechanisms by which leukocytes promote are not completely understood. The degranulation of mast cells releases inflammatory molecules, including TNF, whether these participate in pathogenesis AKI is unknown. Here, we induced with cisplatin cell-deficient and wild-type mice. Compared mice, deficiency attenuated renal injury, reduced serum levels inflamed kidney. Mast mice also exhibited significantly lower intrarenal...
Retinoic acids, a group of natural and synthetic vitamin A derivatives, have potent antiproliferative anti-inflammatory properties. Recently, retinoic acids were reported to inhibit Th1 cytokine production. We investigated the effects acid on lupus nephritis in model NZB/NZW F(1) (NZB/W F(1)) mice. Three-month-old NZB/W mice separated into two groups: one treated with all-trans-retinoic (ATRA; 0.5 mg i.p., three times weekly for 7 mo) saline as control. Compared controls, ATRA-treated...
Nephrotoxicity is a frequent complication of cisplatin-based chemotherapy, in which T cells are known to promote acute kidney injury. In this study, we examined the role cell immunoglobulin mucin 1 (Tim-1) cisplatin-induced injury using an inhibitory anti-Tim-1 antibody. Tim-1 acts modulate responses, but it also expressed by damaged proximal tubules kidney, where as molecule-1 (Kim-1). Anti-Tim-1 antibodies attenuated cisplatin nephrotocity, with less histologic damage, improved renal...
Background Interleukin (IL)-18 is markedly elevated in systemic inflammatory diseases that cause the ‘cytokine storm’ such as adult-onset Still’s disease (AOSD) and hemophagocytic lymphohistiocytosis (HLH). The differences IL-18 between AOSD HLH, especially adults, uncertain. Macrophage activation syndrome (MAS), a form of secondary often difficult to differentiate cases include MAS from other HLH. In this case-control study, we investigated whether serum levels could be useful biomarker for...
Abstract Data on the safety of Janus kinase inhibitors (JAKis) in patients with renal impairment are lacking. This study aimed to investigate JAKis compared biological (b) DMARDs rheumatoid arthritis (RA) and impairment. We used a multi-centre observational registry RA Japan (the ANSWER cohort). assessed drug retention rates b/targeted synthetic different modes action (tumour necrosis factor (TNFis), immunoglobulins fused cytotoxic T-lymphocyte antigen (CTLA-4-Ig), interleukin-6 receptor...
Abstract Autoimmune disease in Fas-deficient MRL-Faslpr mice is dependent on infiltrating autoreactive leukocytes and autoantibodies, IFN-γ plays an important role the pathogenesis. As IL-18 capable of inducing production T cells, we hypothesized that signaling through IL-18R involved To investigate impact this autoimmune disease, generated strain deficient IL-18Rα. Compared with wild-type strain, IL-18Rα-deficient survived longer showed a significant reduction renal pathology, including...
Biomarkers of disease activity in lupus nephritis (LN) are needed. Ideally, such biomarkers would be capable detecting early sub-clinical and could used to gauge response therapy, thus obviating the need for serial renal biopsies. Much focus search LN has been on measurement urinary chemokines cytokines patients. However, these have yet widely implemented clinical practice. Kidney injury molecule-1 (Kim-1) is expressed damaged tubules, but whether (u) tubular (t)-Kim-1 serve as a biomarker...
Corticosteroids are highly effective anti-inflammatory or immunosuppressive drugs used commonly to treat human systemic lupus erythematosus (SLE). All-trans-retinoic acid (ATRA), which belongs a class of retinoids that exert immunomodulatory and functions, can also suppress the development nephritis in an animal model. However, both agents inflict serious adverse effects. Here, we have asked whether ATRA serve as steroid-sparing drug treatment nephritis. To examine efficacy combining...
Nephrotoxicity is a frequent complication of cisplatin-induced chemotherapy, in which T cells are known to promote acute kidney injury (AKI). Apoptosis and necrosis tubules inflammatory events also contribute the nephrotoxicity. A delineation mechanisms that underlie inappropriate renal tubular inflammation can thus provide important insights into potential therapies for AKI. Rho-kinases act as molecular switches controlling several critical cellular functions, including cell migration,...
The proinflammatory cytokine interleukin (IL)-18 is an important mediator of the organ failure induced by endotoxemia. IL-18 (known as interferon-gamma (IFN-γ) inducing factor), and other inflammatory cytokines have roles in lipopolysaccharide (LPS)-induced acute kidney injury (AKI). We investigated effect Toll-like receptor 4 (TLR4) expression, event that accompanied influx monocytes, including CD4+ T cells antigen-presenting (APCs) IL-18Rα knockout (KO) mice wild-type (WT) after LPS...
While targeting the interleukin-6 receptor (IL-6R) through use of sarilumab (SAR) or tocilizumab (TCZ) has become a major therapeutic approach for rheumatoid arthritis (RA), direct comparisons between IL-6R inhibitors (IL-6Ris) treating RA have not been conducted. We aimed to compare effectiveness subcutaneous (SAR-SC), (TCZ-SC), and intravenous TCZ (TCZ-IV) against in multicenter cohort study. Within target trial emulation framework, an incident new-user active-comparator design was used....
Abstract Objectives This multicentre retrospective study aimed to evaluate differences in drug continuation rates and efficacy between first- second-line use of biological disease-modifying antirheumatic drugs (bDMARDs) Janus kinase inhibitors (JAKi) after failure the initial therapy real-world rheumatoid arthritis (RA) settings. Methods Data from an observational registry patients with RA Japan were analysed, encompassing 5,900 treatment courses (4,046 bDMARD/JAKi-naïve cases 1,854 s-line...
Interleukin (IL)-18 expression in synovial tissue correlates with the severity of joint inflammation and levels pro-inflammatory cytokines. However, role IL-18/IL-18 receptor-alpha (Rα) signaling pathway autoimmune arthritis is unknown. Wild-type (WT) IL-18Rα knockout (KO) mice were immunized bovine type II collagen before onset induced by lipopolysaccharide injection. Disease activity was evaluated semiquantitative scoring histologic assessment. Serum inflammatory cytokine anticollagen...