A5111518963- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Mast cells and histamine
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Pharmacy and Medical Practices
- Glycosylation and Glycoproteins Research
- Cancer Treatment and Pharmacology
- CNS Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Hepatitis C virus research
- T-cell and Retrovirus Studies
- BRCA gene mutations in cancer
- Histiocytic Disorders and Treatments
- Chemotherapy-related skin toxicity
Osaka University Hospital
2011-2025
Yamaguchi University
2025
Toyonaka Municipal Hospital
2024
Osaka University
2006-2021
Hyogo Medical University
2002-2003
Friedrich Schiller University Jena
2003
University of Münster
2000-2003
University Hospital Münster
2001-2002
Klinik für Schlafmedizin
2002
The University of Tokyo
2002
Notch and HOXB4 have been reported to expand hematopoietic stem cells (HSCs) in vitro. However, their critical effector molecules remain undetermined. We found that the expression of c-myc, cyclin D2, D3, E, E2F1 was induced or enhanced during Notch1- HOXB4-induced self-renewal murine HSCs. Since c-Myc can act as a primary regulator G1/S transition, we examined whether alone induce In culture with cell factor, FLT3 ligand, IL-6, 4-hydroxytamoxifen-inducible form (Myc/ERT) enabled Lin–Sca-1+...
The scaffolding adapter Gab2 mediates cell signaling and responses evoked by various extracellular stimuli including several growth factors. Kit, the receptor for stem factor (SCF), plays a critical role in proliferation differentiation of variety types, mast cells. via Tyr(567) Tyr(719), activates Src family kinases (SFK) PI3K respectively, which converge on activation Rac/JNK pathway required proliferation. However, how Kit signals to is not well understood. By analyzing Gab2(-/-) cells,...
The effects of Notch signals on the erythroid/megakaryocytic differentiation hematopoietic cells were examined. Activation by intracellular Notch1 or an estradiol-inducible form Notch1/ER suppressed expression erythroid marker glycophorin A in cell line K562. Although Mock-transfected K562 underwent megakaryocytic response to 12-O-tetradecanoylphorbol-13-acetate (TPA), estradiol-activated induced apoptosis during TPA treatment transfectant, which was accompanied reduced antiapoptotic...
To determine the tentative diagnostic criteria and disease severity classification for Castleman (CD) describe clinical pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in Japanese population.We established working groups research of Japan had meetings to discuss define CD. We subsequently analyzed 142 patients classified into iMCD by using nationwide patient registry.We proposed preliminary based on our discussion. In addition, we made a...
Summary. In this study, we examined osteopontin (OPN) production in myeloma cells and plasma OPN levels multiple (MM) patients. We assessed bone marrow (BMCs) by immunocytochemistry enzyme‐linked immunosorbent assay (ELISA). also various B‐cell malignant cell lines, including three lines reverse transcription polymerase chain reaction (RT‐PCR) Western blotting. addition, measured concentrations ELISA 30 MM patients, 21 monoclonal gammopathy of undetermined significance (MGUS) patients...
In this study, we analyzed the roles for AML1/RUNX1 in regulation of c-mpl promoter. Wild-type AML1 activated promoter through proximal AML-binding site luciferase assays using 293T and HeLa cells. accord with result, electrophoretic mobility shift assay chromatin immunoprecipitation demonstrated that bound to site. Next, function a mutant lacking C terminus (AML1dC), which was originally found patient myelodysplastic syndromes. AML1dC dominant-negatively suppressed transcriptional activity...
Castleman's disease (CD) appears at ubiquitous lymph nodes. To date, detection of the lesion focus for CD has mainly been carried out by physical examination and radiological findings, such as X-ray analysis, CT MRI. 18F-FDG PET visualizes active glucose metabolism clinical value investigated many different tumours. Previous studies have only reported four cases unicentric no multicentric CD. In this paper, we report two CD, one with We demonstrate that use monitoring patients especially...
Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.Methods: We assessed baseline data for 342 Japanese MCD with a biopsy-proven diagnosis, enrolled prospective, observational study tocilizumab treatment.Results: Of patients, 86.0% had plasma-cell type. None family history MCD. Median duration was 3.7 years. Mean body weight and mass index tended to be lower than those general population. The most common clinical presentations...
Huntingtin-associated protein 1 (HAP1) is an essential constituent of the stigmoid body (STB) and known as a neuroprotective interactor with causal agents for several neurodegenerative disorders, including huntingtin (HTT) in Huntington's disease. Previous vitro studies showed that compared to normal HTT, STB/HAP1 exhibited higher binding affinity mutant HTT. However, detailed vivo relationships endogenous HTT have not been clarified yet. This study examined distribution its adult mouse...
Although GATA-1 and GATA-2 were shown to be essential for the development of hematopoietic cells by gene targeting experiments, they also reported inhibit growth cells. Therefore, in this study, we examined effects on cytokine signals. A tamoxifen-inducible form (GATA-1/ERT) showed a minor inhibitory effect interleukin-3 (IL-3)-dependent an IL-3-dependent cell line Ba/F3. On other hand, it drastically inhibited TPO-dependent gp130-mediated growth/survival Similarly, estradiol-inducible...
A 17-year-old female developed natural killer (NK) cell-derived large granular lymphocyte (LGL) lymphoma of the lung. She had a past history hypersensitivity to mosquito bites (HMB). After an eight-year chronic, active Epstein-Barr virus (EBV) infection, she multiple lung lesions and pleural effusion. In effusion, 60% cells were LGL. They CD2+, 3-, 16+, 56+, 57+, 45RO+/RA + weak, possessed strong NK activity. No rearrangement T-cell-receptor genes was detected. From all these results,...
Malignant lymphoma frequently develops in the pleural cavity of patients with over 20 years' history pyothorax. The term pyothorax‐associated (PAL) has been proposed for this type tumor. We established four novel cell lines (OPL‐3, ‐4, ‐5, and ‐7) from PAL. Characteristics are as follows: B‐cell nature defective expression T‐cell surface antigens, monoclonal pattern Epstein‐Barr virus (EBV) infection cells (thus indicating an etiological role EBV lymphomagenesis), complicated chromosomal...