A5004956939- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Bartonella species infections research
- Monoclonal and Polyclonal Antibodies Research
- Vector-borne infectious diseases
- Renal Diseases and Glomerulopathies
- Blood Coagulation and Thrombosis Mechanisms
- Viral Infections and Vectors
- Blood disorders and treatments
- Streptococcal Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune Cell Function and Interaction
- Complement system in diseases
- Rabies epidemiology and control
- Thermal Regulation in Medicine
- Photodynamic Therapy Research Studies
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- Hydrogen's biological and therapeutic effects
- Peripheral Neuropathies and Disorders
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
Yamaguchi University
2012-2024
GTx (United States)
2016
Osaka City University
2008
Osaka University Hospital
1997-2007
Osaka University
1989-2002
Health and a vibrant life are sought by everyone. To improve quality of (QOL), maintain healthy state, prevent various diseases, evaluations the effects potentially QOL-increasing factors important. Chronic oxidative stress inflammation cause deteriorations in central nervous system function, leading to low QOL. In individuals, aging, job stress, cognitive load over several hours also induce increases suggesting that preventing accumulation caused daily work contributes maintaining QOL...
Abstract Background: Anti-phospholipid (aPL) antibodies (Abs) frequently found in the plasma of patients with systemic lupus erythematosus (SLE) have been associated thrombotic complications. Our aim was to clarify roles thrombosis aPL Abs that react complexes phospholipids and proteins such as β2-glycoprotein I (β2-GPI), prothrombin, protein C, S, annexin V. Methods: We determined prevalence various phospholipid-binding SLE arterial (30 cases), venous (19 thrombocytopenia (14 fetal loss...
The aim of this study was to evaluate the benefit oral ubiquinol-10 supplementation in CFS patients using an open-label and a randomized, double-blinded, placebo-controlled (RCT) study. Twenty with were randomly enrolled 8-week (150 mg ubiquinol-10/day) attending physicians not blinded supplementation. Forty-three assigned receive either mg/day) or placebo every day for 12 weeks. supplementation, total 31 (N = 17 ubiquinol group 14 group) completed beneficial effects observed we conducted...
222 nm far-ultraviolet (F-UV) light has a bactericidal effect similar to deep-ultraviolet (D-UV) of about 260 wavelength. The cytotoxic F-UV not been fully investigated. DLD-1 cells were cultured in monolayer and irradiated with or 254 D-UV. cytotoxicity the two different wavelengths UV was compared. Changes cell morphology after irradiation observed by time-lapse imaging. Differences staining images DNA-binding agents Syto9 propidium iodide (PI) amount cyclobutane pyrimidine dimer (CPD)...
Summary Cerebral infarction is the most common arterial thromboembolic complication in anti-phospholipid antibodies (aPL) syndrome. In an effort to clarify roles of aPL pathogenesis cerebral patients with SLE, we examined levels anti-cardiolipin/β2-glycoprotein I (antiCL/β2-GPI) and anti-phosphatidylserine/prothrombin (anti-PS/PT) addition lupus anticoagulant (LA) activity 126 SLE (35 91 without thrombosis). Both anti-CL/β2-GPI antiPS/PT strongly correlated presence LA activity. The...
Abstract Background: Venous thromboembolic events such as deep vein thrombosis and pulmonary embolism are common manifestations of antiphospholipid syndrome. Our aim was to clarify the roles anti-phospholipid (aPL) antibodies in pathogenesis venous thromboembolism (VTE) patients with systemic lupus erythematosus (SLE). Methods Results: We examined anti-cardiolipin/β2-glycoprotein I (anti-CL/β2-GPI) antibody concentrations, anti-phosphatidylserine/prothrombin (anti-PS/PT) anticoagulant (LA)...
Anti‐prothrombin antibodies (anti‐prothrombin) and anti‐β2‐glycoprotein I (anti‐β2‐GP I) are the most common characterized anti‐phospholipid (aPL) detected using specific enzyme‐linked immunosorbent assay (ELISA) systems. Recently, lupus anti‐coagulant (LA) activity by a phospholipid‐dependent coagulation was reported to be associated with anti‐prothrombin and/or anti–β2‐GP I. Here we show that co‐existence of IgG LA might an essential risk factor for venous thromboembolism (VTE) in patients...
The relationship between arterial or venous thrombosis and the levels of anticardiolipin antibodies (aCL) and/or existence lupus anticoagulant (LA) was studied. 141 patients with systemic erythematosus (SLE) were divided into four groups: aCL single positive (25 cases), LA (11 double negative (80 cases). prevalence higher in (21/25 cases, 84.0%, P <0.01) than that (4/25 16.0%), (1/11 9.1%) (3/80 3.8%). Furthermore, these patients, all (10/10 cases) a high level (> 10 units/ml) had...
Summary Antiphospholipid antibodies (aPL) are well known to be associated with arterial and venous thrombosis. In a series of 180 patients systemic lupus erythematosus (SLE), the prevalence thrombosis was obviously higher in who had both anticardiolipin (aCL) anticoagulant (LA) (17/35, 48.6%, p <0.05) (Table 1) than other bearing aCL or LA alone neither them (2/145, 1.4%). Since substantial fraction former group also thrombocytopenia (12/17, 70.6%), there possibility that might have...
Venous thromboembolism (VTE) is one of the common manifestations in anti-phospholipid (aPL) syndrome. We examined levels IgG antibodies (Abs) to beta2-glycoprotein I (beta2-GP I) and prothrombin, lupus anticoagulant (LA) activity, activated protein C resistance (APC-R), factor V Leiden 96 patients with systemic erythematosus (SLE); 19 VTE 77 without VTE. Acquired APC-R, which was not found any patient mutation, present 33 (34.4%) out SLE. The presence acquired APC-R a strong risk for SLE...
Objective. The main objective of this study was to clarify the role aPLs in pathogenesis arteriosclerosis obliterans (ASO), ischaemic heart disease (IHD) and cerebral vascular disorder (CVD) patients with SLE.
d-dimer is a potential biomarker for the detection of traumatic brain injury (TBI). However, mechanisms that trigger elevation in TBI remain unclear. The purpose this study was to evaluate reliability blood as and determine involved regulating its levels. Nine patients with moderate severe isolated (Glasgow Coma Scale [GCS] score 7–13) were admitted our hospital from May 2013 June 2014. Blood samples collected systemic arteries on arrival at 1, 3, 5, 7 days after injury. levels neuron...
Abstract Fc gamma RIII (CD16), the type three receptor for portion of IgG, is expressed on neutrophils, killer (K)/NK lymphocytes and macrophages. K/NK lymphocyte RIII, which plays a role in antibody-dependent cellular cytotoxicity, an efficient signal transducing molecule, whereas neutrophil immune-complex clearance, seems less transduction. Neutrophil has been reported to be glycan-phosphatidylinositol-anchored membrane protein. Our studies suggest that protein-anchored rather than...