A5037300111- Neuroscience and Neuropharmacology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Heart Rate Variability and Autonomic Control
- Inflammatory mediators and NSAID effects
- Amino Acid Enzymes and Metabolism
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
- Estrogen and related hormone effects
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Nitric Oxide and Endothelin Effects
- Chemical Synthesis and Analysis
- Stress Responses and Cortisol
- Dementia and Cognitive Impairment Research
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Pharmacological Effects and Toxicity Studies
- Monoclonal and Polyclonal Antibodies Research
RIKEN Center for Biosystems Dynamics Research
2015-2025
Hyogo University
2025
Kobe University
2024-2025
Osaka Metropolitan University
2023-2024
Osaka City University
2014-2023
National Institute for Japanese Language and Linguistics
2023
CLS Technology (Norway)
2013-2018
RIKEN
2006-2018
The University of Tokyo
2013-2018
Compass (United States)
2017
Soluble oligomers of amyloid beta (Abeta), rather than fibrils, have been proposed to initiate synaptic and cognitive dysfunction in Alzheimer's disease (AD). However, there is no direct evidence humans that this mechanism can cause AD. Here, we report a novel precursor protein (APP) mutation may provide address question.A Japanese pedigree showing Alzheimer's-type dementia was examined for mutations APP, PSEN1, PSEN2. In addition, 5,310 people, including 2,121 patients with AD, were...
Electrophilic neurite outgrowth-promoting prostaglandin (NEPP) compounds protect neurons from oxidative insults. At least part of the neuroprotective action NEPPs lies in induction hemeoxygenase-1 (HO-1), which, along with other phase II enzymes, serve as a defense system against stress. Here, we found that, by using fluorescent tags and immunoprecipitation assays, are taken up preferentially into bind thiol-dependent manner to Keap1, negative regulator transcription factor Nrf2. By binding...
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disease characterized by chronic, profound, disabling, and unexplained fatigue. Although it hypothesized that brain inflammation involved in the pathophysiology of CFS/ME, there no direct evidence neuroinflammation patients with CFS/ME. Activation microglia or astrocytes related to neuroinflammation. <sup>11</sup>C-(<i>R</i>)-(2-chlorophenyl)-<i>N</i>-methyl-<i>N</i>-(1-methylpropyl)-3-isoquinoline-carboxamide...
The purpose of this study was to determine the safety, distribution, internal dosimetry, and initial human epidermal growth factor receptor 2 (HER2)–positive tumor images <sup>64</sup>Cu-DOTA-trastuzumab in humans. <b>Methods</b>: PET performed on 6 patients with primary or metastatic HER2-positive breast cancer at 1, 24, 48 h after injection approximately 130 MBq probe <sup>64</sup>Cu-DOTA-trastuzumab. Radioactivity data were collected from blood, urine, normal-tissue samples these...
It is known that chronic fatigue associated with sympathetic hyperactivity. However, the relationship between autonomic function and mental caused by a prolonged load in healthy humans still unclear. Thus, order to clarify mechanisms underlying fatigue, we examined association functions. The study group comprised 10 participants. To induce participants performed tasks, which consisted of advanced trail making test, kana pick-out test mirror drawing for 8 hr, corresponding normal work day....
Ni/Cu-catalyzed transformation of fluoroarenes to arylboronic acid pinacol esters via C-F bond cleavage has been achieved. Further versatile derivatization an ester allowed for the facile two-step conversion a fluoroarene diverse functionalized arenes, demonstrating synthetic utility method.
Fever is triggered by an elevation of prostaglandin E(2) (PGE(2)) in the brain. However, mechanism its remains unanswered. We herein cloned rat glutathione-dependent microsomal E synthase (mPGES), terminal enzyme for PGE(2) biosynthesis, and examined induction brain after intraperitoneal injection pyrogen lipopolysaccharide (LPS). In Northern blot analysis, mPGES mRNA was weakly expressed under normal conditions but markedly induced between 2 4 hr LPS injection. situ hybridization study...
Cyclooxygenase-2 (COX-2), a key enzyme in the biosynthesis of prostaglandins, is induced brain blood vessels by pyrogens, and its essential role fever has been hypothesized. In this study, we determined (1) type cells that express cyclooxygenase-2 lipopolysaccharide-treated rats, (2) precise relationship between time course protein expression these cells. Five hours after lipopolysaccharide injection (100 μg/kg, i.p.), cyclooxygenase-2-like immunoreactive were found parenchymal...
Metabotropic glutamate receptors (mGluRs) consist of eight different subtypes and exert their effects on second messengers ion channels via G-proteins. The function individual mGluR in the CNS, however, largely remains to be clarified. We examined fear response freezing after electric shock wild-type mGluR7(-/-) knockout littermates. Wild-type mice displayed immediately 1 d footshock. In comparison, showed significantly reduced levels both immediate postshock delayed responses. However,...
Abstract Background Fatigue is a crucial sensation that triggers rest, yet its underlying neuronal mechanisms remain unclear. Intense long-term fatigue symptom of chronic syndrome, which used as model to study the fatigue. Methods Using magnetic resonance imaging, we conducted voxel-based morphometry 16 patients and 49 age-matched healthy control subjects. Results We found with syndrome had reduced gray-matter volume in bilateral prefrontal cortex. Within these areas, reduction right cortex...
<h3>Background</h3> Supported by compelling genetic data regarding early-onset familial Alzheimer disease (AD), the amyloid β-peptide (Aβ)–centric theory holds that Aβ is involved in pathogenesis of sporadic AD. Mutations precursor protein (<i>APP</i>), presenilin 1 (<i>PSEN1</i>), and 2 (<i>PSEN2</i>) genes lead to increased levels before symptoms arise. <h3>Objectives</h3> To evaluate pattern Pittsburgh Compound B (PiB) retention subjects with different autosomal dominant mutations...
Abstract Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–Au III was designed developed that enables organ‐specific, localized propargyl ester amidation with nearby proteins live mice. The targeted reactivity can be imaged through the use of Cy7.5‐ TAMRA‐linked based fluorescent probes. This targeting system could enable exploitation other metal strategies for biomedical clinical applications.
Background:Considering the high prevalence of dementia, it would be great value to develop effective tools improve cognitive function. We examined effects a human-type communication robot on function in elderly women living alone.Material/Methods:In this study, 34 healthy female volunteers alone were randomized with either or control at home for 8 weeks. The shape, voice, and motion features resemble those 3-year-old boy, while was not designed talk nod. Before 4 weeks after robot,...
Fatigue can be classified as mental and physical depending on its cause, each type of fatigue has a multi-factorial nature. We examined the effect central nervous system using electroencephalography (EEG) in eighteen healthy male volunteers.After enrollment, subjects were randomly assigned to two groups single-blinded, crossover fashion perform types fatigue-inducing experiments. Each experiment consisted four 30-min 0- or 2-back test sessions evaluation performed just before after sessions....
Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensive metabolomic analyses of 133 plasma samples obtained from CFS patients healthy controls to establish an objective diagnosis CFS. exhibited significant differences in intermediate...
The purpose of this study was to determine whether brain metastases from HER2-positive breast cancer could be detected noninvasively using positron emission tomography (PET) with (64)Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-trastuzumab.PET performed on five patients cancer, at 24 or 48 h after the injection approximately 130 MBq probe (64)Cu-DOTA-trastuzumab. Radioactivity in metastatic tumors evaluated based PET images patients. Autoradiography,...