A5034839994- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipoproteins and Cardiovascular Health
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Radiation Detection and Scintillator Technologies
- Metabolism, Diabetes, and Cancer
- Histone Deacetylase Inhibitors Research
- HIV Research and Treatment
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Cerebrovascular and Carotid Artery Diseases
- Receptor Mechanisms and Signaling
- T-cell and Retrovirus Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Monoclonal and Polyclonal Antibodies Research
- Muscle metabolism and nutrition
RIKEN Center for Biosystems Dynamics Research
2015-2025
National Institutes for Quantum Science and Technology
2023-2025
The University of Tokyo
2022
Kavli Institute for the Physics and Mathematics of the Universe
2022
RIKEN BioResource Research Center
2019
University of Miyazaki
2015
Shiga Medical Center
2015
RIKEN Center for Computational Science
2007-2013
Chiba University
2008-2013
RIKEN
2012
The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy major histocompatibility complex (MHC)-matched allogeneic neural grafting in brain, which less immune-responsive tissue, using iPSCs derived from an MHC homozygous cynomolgus macaque. Positron emission tomography imaging reveals neuroinflammation...
Extensive pharmacological studies have recently emerged indicating that group 2 metabotropic glutamate receptors (mGluRs) comprising mGluR2 and mGluR3 subtypes are associated with several neurological psychiatric disorders. is widely distributed both presynaptically postsynaptically in a variety of neuronal cells, but the physiological role brain function poorly understood. This investigation involves comprehensive behavioral analysis –/– knockout (KO) mice to explore function. Although,...
On target: Lysine residues in picomole samples of a peptide, proteins, and monoclonal antibody were rapidly selectively labeled by dota-based probe (1, see scheme). Positron emission tomography imaging [68Ga]dota-labeled orosomucoid asialoorosomucoid for the first time visualized difference clearance process glycoproteins presence or absence sialic acid residue. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z702989_s.pdf from...
Ketamine is a unique anesthetic reagent known to produce various psychotic symptoms. has recently been reported elicit long-lasting antidepressant effect in patients with major depression. Although recent studies provide insight into the molecular mechanisms of effects ketamine, mechanism not fully elucidated. To understand involvement brain serotonergic system actions we performed positron emission tomography (PET) study on non-human primates. Four rhesus monkeys underwent PET two serotonin...
Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.
In vivo imaging, such as PET, requires restriction of body movements and is generally conducted under sedation by anesthetic agents in studies using laboratory animals. Because anesthetics reduce neural activity metabolism, physiologic functions are difficult to assess animal PET studies. Therefore, use an appropriate method conscious animals important a practical requirement for brain imaging Here, we established system mice reveal the regional cerebral glucose metabolic rate (rCMRglu) with...
Epigenetic modifications mediated by histone deacetylases (HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors (HDACIs) have shown promise therapy. However, pharmacodynamic profiles many HDACIs brain remain largely unknown due to lack validated methods for noninvasive imaging expression-activity. In this study, dynamic PET/CT was performed 4 rhesus macaques using [(18)F]FAHA, a novel substrate, [(18)F]fluoroacetate, major radio-metabolite fused...
Recent clinical trials using rosuvastatin, a hydrophilic statin, did not show beneficial effects on cardiovascular events in patients with heart failure. We examined the cardioprotective of pitavastatin, lipophilic Japanese chronic failure (CHF).A total 574 CHF were randomly assigned to pitavastatin group (n=288) or control (n=286). There was no significant difference between 2 groups for primary outcome, which composite cardiac death and hospitalization worsening HF (adjusted hazard ratio...
P-glycoprotein (P-gp) plays a pivotal role in limiting the penetration of xenobiotic compounds into brain at blood–brain barrier (BBB), where its expression increases with maturation rats. We investigated developmental changes P-gp function BBB nonhuman primates using PET <i>R</i>-<sup>11</sup>C-verapamil, radiotracer useful for evaluating function. In addition, <sup>11</sup>C-oseltamivir, substrate P-gp, was as practical examples. <b>Methods:</b> studies infant (age, 9 mo), adolescent 24–27...
Through a retrospective analysis of existing FDG PET-MRI images, we recently demonstrated that metformin increases the accumulation in intestinal lumen, suggesting stimulates glucose excretion into intestine. However, details this phenomenon remain unclear. We here investigate detailed dynamics excretion, including rate and metabolism excreted glucose, both presence absence metformin. quantified using newly developed PET-MRI-based bioimaging individuals with type 2 diabetes, treated...
Existing models of frontotemporal dementia (FTD) may not fully recapitulate the pathophysiology disease. To generate more pathophysiologically relevant FTD models, we engineered MAPT knockin mouse lines carrying triple mutations, among which MAPTP301S;Int10+3;S320F line exhibited robust tau pathology starting before 6 months age. Severe accumulation was predominantly observed in thalamus, hypothalamus, and amygdala with milder involvement cortex hippocampus, leading to synaptic loss, brain...
Experimentally induced changes in the central visual pathway were studied by using positron emission tomography monkeys with unilateral hypertension glaucoma. In 2-[18F]fluoro-2-deoxy-glucose studies, monocular stimulation of affected eye yielded significantly reduced neural responses occipital visuocortical areas. The response reduction was limited to cortex ipsilateral eye, indicating unique vulnerability experimental addition, [11C]PK11195 and immunohistochemical selective accumulation...
Multi-isotope imaging in vivo is an appealing molecular approach that provides extensive information about pathways cannot be accessed usual methods with a single radioactive probe. However, conventional systems have limited energy resolution; as result, the images obtained from multi-isotope are associated problems, such nonnegligible noise and spectral crosstalk, owing to photons emitted radioisotopes being simultaneously used experiments. This study proposes novel small-animal SPECT...