A5061115590- Synthetic Organic Chemistry Methods
- HER2/EGFR in Cancer Research
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Sesquiterpenes and Asteraceae Studies
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
- Radiopharmaceutical Chemistry and Applications
- Rice Cultivation and Yield Improvement
- Marine Sponges and Natural Products
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Medical Imaging Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Agricultural Economics and Practices
- Bryophyte Studies and Records
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Cancer Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of California, San Francisco
2008-2017
Bangur Institute of Neurosciences
2015
Institute of Neurosciences Kolkata
2015
The University of Texas MD Anderson Cancer Center
2006-2014
Imaging Center
2009-2011
The University of Texas at Austin
2007-2010
Standard Imaging (United States)
2008
Scripps MD Anderson Cancer Center
2006
Laboratoire de Synthèse Organique
2005
Centre National de la Recherche Scientifique
2005
Abstract The proteasome inhibitor bortezomib (formerly known as PS-341) recently received Food and Drug Administration approval for the treatment of multiple myeloma, its activity is currently being evaluated in solid tumors. Bortezomib triggers apoptosis pancreatic cancer cells, but mechanisms involved have not been fully elucidated. Here, we show that cells exposed to formed aggregates ubiquitin-conjugated proteins (“aggresomes”) vitro vivo. Bortezomib-induced aggresome formation was...
Abstract Epidermal growth factor receptor (EGFR/ErbB1) and HER2 (ErbB2/neu), members of the ErbB tyrosine kinase family, are frequently overexpressed in breast cancer known to drive tumor progression, making them promising targets for therapy. Lapatinib is a selective competitive inhibitor both EGFR kinases. Although lapatinib showed significant activity patients with HER2-positive cancer, role response has not been defined. Here, we examined expression levels sensitivity HER2-overexpressing...
Epigenetic modifications mediated by histone deacetylases (HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors (HDACIs) have shown promise therapy. However, pharmacodynamic profiles many HDACIs brain remain largely unknown due to lack validated methods for noninvasive imaging expression-activity. In this study, dynamic PET/CT was performed 4 rhesus macaques using [(18)F]FAHA, a novel substrate, [(18)F]fluoroacetate, major radio-metabolite fused...
Abstract We have previously shown that the antiallergic drug cromolyn blocks S100P interaction with its receptor for advanced glycation end product (RAGE) and improves gemcitabine effectiveness in pancreatic ductal adenocarcinoma (PDAC). However, concentration required to achieve was high (100 μmol/L). In this study, we designed synthesized analogs of analyzed their compared parent molecule. An ELISA used confirm binding RAGE test different analogs. Analog 5-methyl (C5OH) blocked as well...
Abstract BACKGROUND: Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced (LABC). Patients with IBC commonly present skin metastasis, which are observed microscopically as tumor emboli within dermal lymphatics. These metastatic cells aberrantly overexpress E‐cadherin and exhibit ability to undergo self‐renewal highly invasive. There no therapeutics yet identified that target structure functions emboli. The studies evaluated effects pan‐histone deacetylase (HDAC)...
Abstract Histone deacetylase (HDAC) inhibitors are new and promising antineoplastic agents. Current methods for monitoring early response rely on invasive biopsies or indirect blood-derived markers. Our goal was to develop a magnetic resonance spectroscopy (MRS)–based method detect HDAC inhibition. The fluorinated lysine derivative Boc-Lys-(Tfa)-OH (BLT) investigated as 19F MRS molecular marker of activity together with 31P endogenous metabolites. In silico modeling the BLT-HDAC interaction...
Histone deacetylase inhibitors (HDACis) are emerging as promising and selective antitumor agents. However, HDACis can lead to tumor stasis rather than shrinkage, in which case, traditional imaging methods not adequate monitor response. Consequently, novel approaches needed. We have shown cells that 19 F magnetic resonance spectroscopy (MRS)-detectable levels of the HDAC substrate Boc-Lys-TFA-OH (BLT) inversely correlated with activity. extended our investigations a xenograft model. Following...
Early diagnosis of pancreatic carcinoma with highly sensitive diagnostic imaging methods could save lives many thousands patients, because early detection increases resectability and survival rates. Current non-invasive techniques have inadequate resolution sensitivity for small size ( approximately 2-3 mm) lesions. Therefore, we assessed the efficacy positron emission tomography computer (PET/CT) beta-O-D-galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoroethyl-D-glucopyranose ([(18)F]FEDL)...
Kit is a membrane-bound tyrosine kinase and receptor for stem cell factor (SCF) with crucial role in hematopoiesis. Mutations of KIT occur almost half patients core-binding leukemias, which they have been associated worse outcome. Development new compounds targeting may therefore hold promise therapy. We investigated the activity mechanism action APcK110, novel inhibitor, mastocytosis line HMC1.2 (KITV560G KITD816V), acute myeloid leukemia (AML) lines OCIM2 OCI/AML3 (both wild-type), primary...
Abstract IFIXα, a member of the interferon‐inducible HIN‐200 family, has been identified as putative tumor suppressor. However, molecular mechanisms underlying IFIXα‐mediated suppression are poorly understood. In present study, we demonstrated that metastasis suppressor maspin acts downstream target IFIXα. IFIXα suppressed invasion activity MDA‐MB‐468 breast cancer cells, and its inhibitory effect was reversed by knockdown maspin. Both Maspin mRNA protein were upregulated Histone deacetylase...
Correlating mechanical forces with quantifiable physical changes in the dentoalveolar complex.Male 6-week C57BL/6 mice (N=3), micro X-ray-computed tomography; post-analysis software to extract periodontal ligament (PDL)-space.Silicone-elastic bands were placed between maxillary molars for 1 week, contralateral side as internal control. Average displacements crowns and roots, PDL-spaces evaluated by registering X-ray tomograms of experimental control hemi-maxillae. Histology illustrated...
The copper(I)-induced synthesis of 1,2,3-triazoles using azides and alkynes (click chemistry) has become extremely significant.Click chemistry been used in all aspects drug discovery research.The product triazole serves as a linker it readily combines with targets through hydrogen-bonding dipole interaction.This review summarizes the application click triazoles anticancer drugs.These types reactions proceed high selectivity, specificity, yields.A variety complex molecules are synthesized by...
Rice yield underperformance coupled with production instability in Odisha state of India is primarily due to low irrigation potential, the spatiotemporal disparity rainfall pattern and relentless confrontation biotic abiotic stresses. System Intensification (SRI) was introduced promises higher horizon. However, present scenario patchy adoption has necessitated comprehensive study on dynamics determinants SRI. We found that, 57 percent farmers continued SRI, 28 discontinued rest were...