A5101900410- Finite Group Theory Research
- Ocular Oncology and Treatments
- graph theory and CDMA systems
- Viral-associated cancers and disorders
- Pancreatitis Pathology and Treatment
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Corneal Surgery and Treatments
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Rings, Modules, and Algebras
- Traditional Chinese Medicine Analysis
- Advanced Topics in Algebra
- Congenital Anomalies and Fetal Surgery
- Bone Metabolism and Diseases
- Phagocytosis and Immune Regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Research and Treatments
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Geometric and Algebraic Topology
Sichuan University
2023-2025
Qingdao University
2009-2025
Affiliated Hospital of Qingdao University
2021-2025
Lanzhou University
2020-2025
Capital Normal University
2023-2024
Children's Hospital of Zhejiang University
2022-2024
First Affiliated Hospital of Kunming Medical University
2022
Kunming Medical University
2022
Osaka University
2002-2020
Sichuan Mianyang 404 Hospital
2020
Human papillomavirus (HPV) type 16 is one of the major etiologic factors cervical cancer. Our study aims to investigate potentiality antiviral clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system (CRISPR/Cas9) targeting E6 and E7 oncogenes HPV16 as a potential chemosensitizer cisplatin (cis-diaminedichloroplatinum II; CDDP) for cancer.Specifically, therapeutic efficacy combination CDDP + E7-CRISPR/Cas9 was assessed in cancer cells xenograft...
Degradation of the basement membrane by MMPs (matrix metalloproteinases) is one most critical steps in tumour progression. CD147 a tumour-associated antigen that plays key regulatory role for MMP activities. In present study, mass spectrum analysis demonstrated purified native from human lung cancer tissue was N-glycosylated and contained series high-mannose complex-type N-linked glycan structures. Moreover, glycosylated existed exclusively as oligomers solution directly stimulated...
Abstract Polyphenol resveratrol ( RSV ) has been associated with S ilent I nformation R egulator T 1 SIRT 1) and AMP ‐activated protein kinase AMPK metabolic stress sensors probably responds to the intracellular energy status. Our aim here was investigate neuroprotective effects of its association signaling in recurrent ischemia models. In this study, elderly male W istar rats received a combination two mild transient middle cerebral artery occlusions tMCAO s) as an vivo ischemic model....
Abstract Purpose Choroidal melanoma (CM), a kind of malignant tumor, is the main type Uveal and one half CM patients develop metastases. As member Eph/ephrin pathway that plays vital role in tumors, EphrinA3 (EFNA3) has been proved to promote tumorigenesis many tumors. But effect EFNA3 not studied yet. Through inhibiting angiogenesis, inducing apoptosis autophagy so on, Artesunate (ART) key anti-tumor including CM. However, exact mechanisms remain unclear. Methods The UALCAN TIMER v2.0...
Background: The occurrence of cisplatin (DDP) resistance in oral squamous cell carcinoma (OSCC) is a major challenge for OSCC treatment. Circular RNAs (circRNAs) have been associated with the development cancer resistance, but role circ_0109291 DDP unclear. Methods: expression and microRNA-188-3p (miR-188-3p) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell counting kit 8 (CCK8) assay, colony formation flow cytometry were performed to measure proliferation,...
Whether circulating histones in gut lymph contribute to organ failure and impact of chaiqin chengqi decoction (CQCQD) on severe acute pancreatitis (SAP) remain elusive. To verify the role SAP evaluate effect CQCQD them. Sodium taurocholate was retrogradely infused into pancreatobiliary duct induce rodents. Various regimens were administered intragastrically or via duodenum followed by dynamic collection rats. The endothelial cell viability lymphocytes determined. Components identified...
Angiogenesis and vasculogenic mimicry (VM) are considered to be the main processes ensure tumor blood supply during proliferation metastasis of choroidal melanoma (CM). The traditional antimalarial drug artesunate (ART) has some potential anti-CM effects; however, underlying mechanisms remain unclarified. Recent studies have shown that Wnt5a/calmodulin-dependent kinase II (CaMKII) signaling pathway a close correlation with angiogenesis VM formation. This study demonstrated ART eliminated...
Abstract Let $X=GC$ be a group, where C is cyclic group and G either generalized quaternion or dihedral such that $C\cap G=1$ . In this paper, X characterized and, moreover, complete classification for $X$ given, provided core-free.
Recently we reported the different frequenties of p53 and c‐kit gene mutations among sinonasal NK/T cell lymphoma (NKTCL) in Korea, north China (Beijing), Japan, suggesting some racial, environmental, or life‐style differences as a possible cause nasal tumorigenesis. In this study, p53, , K‐ras, β‐catenin were analyzed by polymerase chain reaction (PCR)‐single strand conformation polymorphism (SSCP) followed direct sequencing 20 cases NKTCL from northeast (Shen Yang). Age patients ranged 5...
Carfilzomib is a second-generation tetrapeptide epoxyketone proteasome inhibitor used in current clinical therapy of hematologic malignancies. The mechanism inhibition endometrial cancer not very clear. type I carcinoma cell proliferation by inducing cycle arrest at the G2/M phase was investigated our study.HEC-1-A and Ishikawa lines three tumor were treated different concentrations carfilzomib. Methyl thiazolyl tetrazolium (MTT) assay to detect viability. Flow cytometry analyze cycle....
Non-small cell lung cancer (NSCLC) is a major type of cancer, leading to high fatality rate. The role circular RNAs (circRNAs) in has been increasingly emphasized and studied. However, the function circ-ZNF124 NSCLC largely unclear, associated regulatory mechanism not Here, we examined expression pattern using quantitative real-time PCR. For functional analysis, proliferation, apoptosis/cycle invasion were investigated MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide]...
The purpose of this study was to uncover potential diagnostic indicators pulmonary arterial hypertension (PAH), evaluate the function immune cells in pathogenesis disease, and find innovative treatment targets medicines with enhance prognosis. Gene Expression Omnibus utilized acquire PAH datasets. We recognized differentially expressed genes (DEGs) investigated their functions utilizing R software. Weighted gene coexpression network analysis, least absolute shrinkage selection operators,...
Malignant lymphoma frequently develops in the pleural cavity of patients with over 20 years' history pyothorax. The term pyothorax‐associated (PAL) has been proposed for this type tumor. We established four novel cell lines (OPL‐3, ‐4, ‐5, and ‐7) from PAL. Characteristics are as follows: B‐cell nature defective expression T‐cell surface antigens, monoclonal pattern Epstein‐Barr virus (EBV) infection cells (thus indicating an etiological role EBV lymphomagenesis), complicated chromosomal...