A5100721619- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- Carcinogens and Genotoxicity Assessment
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- Gut microbiota and health
- Cancer therapeutics and mechanisms
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
Harvard University
2008-2025
Children's Hospital of Fudan University
2012-2025
Shanghai Institute of Materia Medica
2011-2025
Chinese Academy of Sciences
2011-2025
Jilin Agricultural University
2025
Albert Einstein College of Medicine
2025
University of Electronic Science and Technology of China
2021-2025
Fourth Hospital of Hebei Medical University
2024-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
Northwest A&F University
2023-2025
Rosuvastatin is an HMG-CoA reductase inhibitor and one of the most hydrophilic among commercially available statins. It efficiently accumulated in liver excreted into bile unchanged form rats, suggesting that hepatic transporters play a major role its clearance. Therefore, we investigated responsible for uptake biliary excretion rosuvastatin. Uptake studies revealed human organic anion transporting polypeptide (OATP) 1B1, OATP1B3, OATP2B1 accept rosuvastatin as substrate. Among OATP family...
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have been exploited as promising natural delivery platform due to their low toxicity, excellent structural stability, nanoscale size, cargo loading ability, and editable surface structure. To load therapeutic or diagnostic cargos (drugs, nucleic acids, proteins, peptides, nanomaterials) into exosomes, multiple techniques developed, such incubating with exosomes exosome-secreting transfection, physical...
Rationale: During the development of atherosclerosis, macrophages secrete exosomes that regulate vascular smooth muscle cells (VSMCs); however, whether nicotine, a major constituent cigarettes, can modulate this communication in context atherogenesis remains to be further studied. In study, we hypothesized nicotine induces atherogenic containing microRNAs (miRNAs) mediate cell-to-cell crosstalk and encourage proatherogenic phenotypes VSMCs. Methods: an vivo was administered subcutaneously...
Metal–organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (nMOFs, named DCCMH) using...
MDR1/ABCB1, MRP2/ABCC2, and breast cancer resistance protein (BCRP)/ABCG2 are expressed in the liver intestine contribute to disposition of many drugs. Rosuvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor for treatment patients with dyslipidemia, is primarily excreted via bile as unchanged drug. The present study was designed determine whether rosuvastatin transported by MDR1, MRP2, BCRP. apparent permeability value across MDR1-Madin-Darby canine kidney cells low (∼8 nm/s), no...
Human genetic and genomic studies have supported a strong causal role of SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism underlying resulting ASD is not fully understood. Recently, zebrafish has become an attractive organism to model because its high efficiency manipulation robust behavioral phenotypes. The orthologous gene human duplicated genome two homologs, shank3a shank3b. Previous reported shank3 morphants using morpholino method. Here, we report...
The fruit of Lycium ruthenicum Murr. (LRF) has long been used in folk medicine. Nevertheless, detailed information related to its polyphenol compositions remains scarce. In this study, we confirmed that the total phenolic and anthocyanin contents LRF extracts (LRFEs) were 4906.5 ± 60.6 mg gallic acid equivalents/100 g DW 787.6 34.1 cyanindin-3-glucoside DW, respectively. A characterization LRFEs was performed by ultrahigh performance liquid chromatography/quadrupole time-of-flight mass...
Abnormal neddylation activation is frequently observed in human cancers and inhibition has been proposed as a therapy for cancer. Here, we report that MLN4924, small-molecule inhibitor of activating enzyme, increases glutamine uptake breast cancer cells by causing accumulation transporter ASCT2/SLC1A5, via inactivation CRL3-SPOP E3 ligase. We show the ligase SPOP promotes ASCT2 ubiquitylation, whereas itself auto-ubiquitylated upon deprivation. Thus, inversely regulate metabolism. knockdown...
Bimetallic oxide anodes with multi-electron conversion capabilities require hierarchical multi-dimensional structures to provide both a stable framework and abundant lithium-storage active sites for balance of cycling stability reversible capacity....
Abstract Purpose To evaluate the utility of diffusion‐weighted magnetic resonance imaging (DWI) in pancreatic ductal adenocarcinoma with various grades differentiation. Materials and Methods Following Institutional Review Board (IRB) approval, 21 consecutive patients surgical pathology‐proven adenocarcinomas were retrospectively evaluated. Histopathologic characteristics differentiation analyzed. Twenty‐one without a known history disease evaluated as control group. Anatomic MR images DW...
Abstract BACKGROUND The diamondback moth, Plutella xylostella (L.) has developed extremely high resistance to chlorantraniliprole and other diamide insecticides in the field. A glycine glutamic acid substitution ( G4946E ) P. ryanodine receptor PxRyR been found two resistant populations collected Thailand Philippines was considered associated with but no experimental evidence provided. present study aimed clarify function of reported mutation . RESULTS We identified same from four field...
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies worldwide. To reduce high morbidity and mortality disease, sensitive specific biomarkers for early detection are urgently needed. Tumor-specific microRNAs (miRNAs) seem to be potential diagnosis treatment cancer. In this study, differentially expressed miRNAs in tumor tissues adjacent non-tumor were detected by miRNA microarrays. Stem-loop real-time reverse transcription PCR was conducted verify candidate...
Background and purposeIt is well known that inflammation influence chronic subdural hematoma (CSDH) formation to a large extent. Atorvastatin has pleiotropic effects on restraining promoting angiogenesis besides its cholesterol-lowering function. Hence, atorvastatin may induce anti-inflammation facilitate therapeutic for (SDH).MethodsAdult male Wistar rats were subjected SDH successful establishment of was confirmed by magnetic resonance imaging (MRI). The treatment initiated 6 hours after...