A5009081991- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Diabetes and associated disorders
- RNA Interference and Gene Delivery
- Per- and polyfluoroalkyl substances research
- Genetic and phenotypic traits in livestock
- HIV/AIDS drug development and treatment
- Folate and B Vitamins Research
- BRCA gene mutations in cancer
- HIV/AIDS Research and Interventions
- Curcumin's Biomedical Applications
- Child Nutrition and Water Access
- Gut microbiota and health
- HIV, Drug Use, Sexual Risk
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Muscle metabolism and nutrition
- HIV Research and Treatment
- Nutritional Studies and Diet
- Heavy Metal Exposure and Toxicity
- Ion Transport and Channel Regulation
Icahn School of Medicine at Mount Sinai
2015-2025
Columbia University
2024-2025
Columbia College
2025
Royal College of Physicians
2025
University of California, San Francisco
2023
University of Cambridge
2020
Neuroscience Institute
2020
Tulane University
2011-2018
University of Southern California
2010-2015
Walker (United States)
2015
Excess fructose consumption is hypothesized to be associated with risk for metabolic disease. Actual levels are difficult estimate because of the unlabeled quantity in beverages. The aims this study were threefold: 1) re-examine content previously tested beverages using two additional assay methods capable detecting other sugars, especially maltose, 2) compare data across all determine actual free fructose-to-glucose ratio made either or without high-fructose corn syrup (HFCS), and 3) expand...
Investigating genetic architecture of complex traits in ancestrally diverse populations is imperative to understand the etiology disease. However, current paucity research people African and Latin American ancestry, Hispanic indigenous peoples United States likely exacerbate existing health disparities for many common diseases. The Population Architecture using Genomics Epidemiology, Phase II (PAGE II), Study was initiated 2013 by National Human Genome Research Institute expand our...
Background Melanocortin 4 receptor (MC4R) deficiency, caused by mutations in MC4R, is the most common cause of monogenic forms obesity. However, these have often been identified small-scale, case-focused studies. Here, we assess penetrance previously reported MC4R at a population level. Furthermore, examine why some carriers pathogenic remain normal weight, to gain insight into mechanisms that control body weight. Methods and findings We 59 known obesity-increasing from Human Gene Mutation...
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic (CMD) and several cancers, with disproportionate impact on marginalized populations. SevO an understudied global health disease, limiting knowledge about its mechanisms impacts. In genome-wide association study (GWAS) meta-analyses the tail end BMI distribution (≥95th percentile BMI) two phenotypes [Obesity Class III ≥40 kg/m2 Obesity IV ≥50 kg/m2] in 159,359 individuals across eleven ancestrally...
OBJECTIVE A genome-wide study of adults identified a variant PNPLA3 (rs738409) associated with ∼twofold higher liver fat. The purpose this was to examine the influence genotype on fat and other related metabolic outcomes in obese Hispanic children adolescents. RESEARCH DESIGN AND METHODS Three hundred twenty-seven Hispanics aged 8–18 years were genotyped for rs738409. One eighty-eight subjects had measures visceral (VAT) subcutaneous (SAT) adipose tissue volume hepatic (HFF) pancreatic (PFF)...
Abstract Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether variants affect body shape as composite phenotype that is represented by combination traits. developed an approach calculates averaged PCs (AvPCs) representing derived from six traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% the variability, are heritable, associate...
Excess added sugar consumption is tied to poor health outcomes in children. The content of beverages and foods children are exposed mostly unknown, yet this information imperative for understanding potential risks from overconsumption sugars early life. We determined actual by conducting a blinded laboratory analysis infant formulas, breakfast cereals, packaged baked goods yogurts. One hundred samples were sent an independent via gas chromatography. Sugar composition was total compared...
Introduction Apolipoprotein C-III (apoC-III) regulates triglyceride (TG) metabolism. In plasma, apoC-III exists in non-sialylated (apoC-III0a without glycosylation and apoC-III0b with glycosylation), monosialylated (apoC-III1) or disialylated (apoC-III2) proteoforms. Our aim was to clarify the relationship between sialylation proteoforms fasting plasma TG concentrations. Methods 204 non-diabetic adolescent participants, relative abundance of measured using mass spectrometric immunoassay....
Metal exposures are associated with gut microbiome (GM) composition and function, early in development may be particularly important. Considering the role of GM association many adverse health outcomes, understanding relationship between prenatal metal is critically However, there sparse knowledge exposure later childhood.
Summary/Abstract Genome-wide association studies (GWAS) have laid the foundation for investigations into biology of complex traits, drug development, and clinical guidelines. However, dominance European-ancestry populations in GWAS creates a biased view role human variation disease, hinders equitable translation genetic associations public health applications. The Population Architecture using Genomics Epidemiology (PAGE) study conducted 26 behavioral phenotypes 49,839 non-European...
Abstract Background Understanding perspectives of subgroups people with HIV (PWH) who have accessed long-acting cabotegravir/rilpivirine (CAB/RPV-LA) is crucial for optimizing implementation; especially among long-term survivors (LTS) lived through the trauma early epidemic to innovation today. Methods We analyzed semi-structured interviews collected from 08/2022-05/2023 via a parent study at four Ryan White clinics in Atlanta, Chicago, and San Francisco adopters CAB/RPV-LA (received ≥3...
Background: Long-acting injectable cabotegravir-rilpivirine (CAB/RPV-LA) is a promising treatment alternative for people with HIV (PWH) who face adherence challenges oral antiretroviral therapy (ART). While its clinical efficacy well-documented, cost-effectiveness data from real-world settings remain limited. Objective: To evaluate the incremental first-year cost and of CAB/RPV-LA versus standard care (SoC) ART among PWH challenges, perspective healthcare payer. Methods: A cohort 59...
Objective: African Americans commonly have lower liver fat accumulation than Hispanics, despite a similar propensity for obesity. Both ethnicities exhibit high consumption of fructose-containing beverages, which has been associated with owing to the lipogenic properties fructose. Therefore, differences in fructose absorption may be an important factor regulating deposition. We hypothesized that malabsorption reduce hepatic delivery fructose, thus contributing deposition compared...
Objective Obesity in childhood is associated with an inflammatory state adipose tissue and liver, which elevates risk for diabetes liver disease. No prior study has examined associations between pathologies occurring to identify elements of damage type 2 risk. This sought determine whether inflammation fibrosis abdominal subcutaneous (SAT) obese/overweight children (BMI-z 2.3 ± 0.76) was related the extent observed disease or Methods Biopsy samples were simultaneously collected from 33...