Gemma Cadby
A5066755720- Genetic Associations and Epidemiology
- Cutaneous Melanoma Detection and Management
- Genetic Mapping and Diversity in Plants and Animals
- Nutrition, Genetics, and Disease
- Obstructive Sleep Apnea Research
- Genetic and phenotypic traits in livestock
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Autism Spectrum Disorder Research
- Occupational and environmental lung diseases
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Genetics and Physical Performance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetics and Neurodevelopmental Disorders
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Skin Protection and Aging
- Adipokines, Inflammation, and Metabolic Diseases
The University of Western Australia
2015-2024
Government of Western Australia Department of Health
2023-2024
Curtin University
2017-2019
International Society for Developmental Origins of Health and Disease
2009-2019
Ontario Institute for Cancer Research
2011-2017
Wellcome Sanger Institute
2016
Sir Charles Gairdner Hospital
2015
Lunenfeld-Tanenbaum Research Institute
2011-2014
Rationale Lung function measures are heritable traits that predict population morbidity and mortality essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication provided conflicting results. Recently, we undertook a meta-analysis Genome Wide Association Study (GWAS) results lung 20,288 individuals from general (the SpiroMeta consortium). Objectives To comprehensively analyse...
Genomic loci are associated with FEV1 or the ratio of to FVC in population samples, but their association chronic obstructive pulmonary disease (COPD) has not yet been proven, nor have combined effects on lung function and COPD studied.To test variants at five (TNS1, GSTCD, HTR4, AGER, THSD4) evaluate joint these single-nucleotide polymorphisms (SNPs), previously reported locus near HHIP.By sampling from 12 population-based studies (n = 31,422), we obtained genotype data 3,284 case subjects...
Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these calls for better understanding the age- consequences. High-throughput lipidomic analyses population-based cohorts offer an opportunity to identify disease-risk–associated biomarkers improve our lipid metabolism biology at a population level. Here, we comprehensively examined relationship between classes/subclasses molecular species with age, sex, body mass index (BMI). Furthermore,...
Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, substantial proportion of patients with these conditions have seemingly normal body mass index (BMI). Conversely, not all obese individuals present metabolic disorders giving rise to the concept "metabolically healthy obese". We use lipidomic-based models BMI calculate score (mBMI) as measure dysregulation associated obesity. Using difference between mBMI (mBMIΔ), we identify similar but differing in their...
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep feeding disorders) the complex interplay between molecular profiles neurodevelopment, genetics, environmental factors health. Here we explored plasma lipidome (783 lipid species) in 765 children (485 diagnosed autism spectrum disorder (ASD)) within Australian Biobank. We identified lipids associated ASD (n = 8), disturbances 20)...
Abstract Objective To estimate the prevalence of long COVID among Western Australian adults, a highly vaccinated population whose first major exposure to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was during 2022 Omicron wave, and assess its impact on health service use return work or study. Study design Follow‐up survey (completed online by telephone). Setting, participants Adult Australians surveyed 90 days after positive SARS‐CoV‐2 test results (polymerase chain reaction...
Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score (FRS) may underperform within diverse intermediate-risk group, which includes individuals requiring distinct management strategies. This study aimed to develop a lipidomic-enhanced score (LRS), specifically targeting prediction and reclassification intermediate benchmarked against FRS. The LRS was developed via machine learning workflow...
Abstract Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether variants affect body shape as composite phenotype that is represented by combination traits. developed an approach calculates averaged PCs (AvPCs) representing derived from six traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% the variability, are heritable, associate...
Abstract Background Low levels of serum adiponectin have been linked to central obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. Variants in ADIPOQ , the gene encoding adiponectin, shown influence concentration, along with variants receptors ( ADIPOR1 ADIPOR2 ) implicated syndrome This study aimed comprehensively investigate association common ADIPOQ, resistance syndromes a large cohort European-Australian individuals. Methods Sixty-four tagging single nucleotide...
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, suggesting involvement other environmental and genetic factors. To identify factors that may contribute development we conducted genome-wide association study (GWAS; 370,000 genotyped SNPs, 5 million imputed SNPs) in Italy, among 407 MPM cases 389 controls with complete history exposure. A replication was also...
There is now substantial evidence that autistic-like traits in the general population lie on a continuum, with clinical autism spectrum disorders (ASD) representing extreme end of this distribution. In study, we sought to evaluate five independently identified genetic associations ASD population. study cohort, phenotype and genomewide association genotype data were obtained from Western Australian Pregnancy Cohort (Raine) Study. The outcome measure used was Autism Spectrum Quotient (AQ),...
CVD is the leading cause of death worldwide, and genetic investigations into human lipidome may provide insight risk. The aim this study was to estimate heritability circulating lipid species their correlation with traits. Targeted lipidomic profiling performed on 4,492 participants from Busselton Family Heart Study quantify major fatty acids 596 33 classes. We estimated narrow-sense heritabilities species/classes correlations eight traits: BMI, HDL-C, LDL-C, triglycerides, total...