A5101686901- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Nitric Oxide and Endothelin Effects
- Gastroesophageal reflux and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Erythropoietin and Anemia Treatment
- Cell Adhesion Molecules Research
- Complement system in diseases
- Wheat and Barley Genetics and Pathology
- Transplantation: Methods and Outcomes
- Advanced Glycation End Products research
- Immunodeficiency and Autoimmune Disorders
Kyung Hee University
2018-2025
Assistance Publique Hôpitaux de Marseille
2024
Hanoi Medical University
2024
California State University, San Bernardino
2022-2024
The University of Texas at Austin
2024
Baker Heart and Diabetes Institute
2020-2023
Vietnam National University Ho Chi Minh City
2023
Terasaki Foundation
2008-2020
Creighton University
2019
Synergy Pharmaceuticals (United States)
2017
We previously demonstrated the presence of advanced oxidation protein products (AOPP), a novel marker oxidative stress in plasma uremic patients receiving maintenance dialysis. The present study cohort 162 showed that concentrations AOPP increased with progression chronic renal failure and were closely related to glycation end (AGE)-pentosidine (r = 0.52, p < 0.001), taken as AGE. In vivo, relevance AGE-pentosidine monocyte-mediated inflammatory syndrome associated uremia was evidenced by...
Oncotype DX is a clinically validated, high-complexity, multianalyte reverse transcription-PCR genomic test that predicts the likelihood of breast cancer recurrence in early-stage, node-negative, estrogen receptor-positive cancer. The Recurrence Score (RS) provides more accurate, reproducible measure aggressiveness and therapeutic responsiveness than standard measures. Individualized patient management requires strict performance criteria for clinical laboratory tests. We therefore...
The fate of octogenarians reaching end-stage renal disease (ESRD) is poorly defined, and implicit dialysis rationing may be practiced in this age group. main objectives study were to analyze the characteristics pre-ESRD offered or not identify factors influencing mortality while on dialysis, improve prognosis assessment decision-making. In single-center cohort, 146 consecutive referred a nephrology unit over 12-yr period (1989 2000). Main outcome measures baseline patients conservative...
Background. Partial correction of anaemia with recombinant human erythropoietin (rHuEpo) has been shown to markedly improve the general condition and quality life predialysis patients, but effects rHuEpo therapy on blood pressure rate progression chronic renal failure (CRF) are still disputed. In particular, no study evaluated time duration until start maintenance dialysis in treated compared untreated patients.
Late nephrological referral of chronic renal failure patients has been shown to be associated with high morbidity and short-term mortality on dialysis. However, the impact predialysis care duration (PNCD) long-term survival dialysis had not evaluated.We studied data from all 1057 consecutive who started treatment at Necker Hospital 1989 1998 (mean age start 53.8+/-17.2 years (range 18-91 years), excluding analysis presented acute (n=60) or advanced malignancy (n=35). We evaluated effects...
Anti-HLA-DQ antibodies are the predominant HLA class II donor-specific (DSAs) after transplantation. Recently, de novo DQ DSA has been associated with worse allograft outcomes. The aim of this study was to determine further complement-binding characteristics most harmful DSA.Single-antigen bead technology used screen 284 primary kidney transplant recipients for presence posttransplantation DSA. Peak sera 34 only and 20 plus other DSAs were analyzed by a modified single-antigen assay using...
Despite the identification of numerous autism susceptibility genes, pathobiology remains unknown. The present "case-control" study takes a global approach to understanding molecular basis spectrum disorders based upon large-scale gene expression profiling. DNA microarray analyses were conducted on lymphoblastoid cell lines from over 20 sib pairs in which one sibling had diagnosis and other was not affected order identify biochemical signaling pathways are differentially regulated cells...
OBJECTIVES: Two identical, phase 3, randomized, double-blind, placebo-controlled trials evaluated the efficacy and safety of plecanatide in patients with irritable bowel syndrome constipation (IBS-C). METHODS: Adults meeting Rome III criteria for IBS-C were randomized (1:1:1) to placebo or (3 6 mg) 12 weeks. The primary end point was percentage overall responders (patients reporting ≥30% reduction from baseline worst abdominal pain plus an increase ≥1 complete spontaneous movement...
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep feeding disorders) the complex interplay between molecular profiles neurodevelopment, genetics, environmental factors health. Here we explored plasma lipidome (783 lipid species) in 765 children (485 diagnosed autism spectrum disorder (ASD)) within Australian Biobank. We identified lipids associated ASD (n = 8), disturbances 20)...
Abstract Despite their potential importance, the role of phagocyte‐derived chloramines (“longlived oxidants”) has not yet been investigated in inflammatory or infectious diseases. We have developed a sensitive spectrophotometric microtiter plate assay for based on capacity to oxidize potassium iodide (Kl). Consistant levels endogenous were detected normal human polymorphonuclear neutrophil (PMN) supernatants after stimulation by phorbol myristate acetate (PMA) opsonized zymosan. Exogenous...
It is a challenging task to verify and quantify potential biomarkers expressed at elevated levels in sera from cancer patients. An immunoaffinity-mass spectrometry-based approach has been developed using antibodies enrich proteins of interest followed by mass quantification. Antibodies specific the protein were immobilized hydrazide resin via carbohydrate moiety on Fc region antibody. Captured eluted, reduced, alkylated, digested with trypsin. Peptides analyzed LC coupled multiple reaction...
Synthetic hexaploid wheat is an effective genetic resource for transferring agronomically important genes from Aegilops tauschii to common wheat. Wide variation in grain size and shape, one of the main targets breeding, has been observed among Ae. accessions. To identify quantitative trait loci (QTLs) responsible shape D genome under a background, six parameters related were measured using SmartGrain digital image software QTL analysis was conducted four F2 mapping populations synthetic...
Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate subclasses, thus potential atherogenicity? What is the effect of statin treatment? Obese hypertriglyceridemic hypercholesterolemic males [n = 12; lipoprotein (a) <10 mg/dl] received pitavastatin calcium (4 mg/day) for 180 days in a single-phase unblinded study. The lipidomic profiles (23 classes) five subclasses fractionated from baseline post-statin plasmas were...
The present prospective study was conducted in order to establish the relationship between complement activation and stimulation of phagocyte oxidative metabolism observed long-term hemodialysis (HD) patients during early phase dialysis with cellulosic membranes. Two groups 10 randomized treated (Cuprophan, CUP) or synthetic polyacrilonitrile (PAN AN-69®) membranes were studied. Leukocyte counts, C3a antigen plasma concentration whole blood basal stimulated chemiluminescence (CL) production...
We evaluated long-lived oxidant potential in the sputum of patients with cystic fibrosis (CF) by quantitating methionine-inhibitable, fraction sputum, referred to as chloramines. Taurine, preferred amino acid substrate for chloramine formation, and myeloperoxidase (MPO), chlorinated oxidant-generating enzyme, were also quantitated. As compared asthmatic subjects, CF contained high concentrations chloramines along levels taurine active MPO. A negative correlation between was found patients....
Epitopes of human leukocyte antigen (HLA) are the sites to which antibodies bind. We identify here 103 HLA class I epitopes shared by groups antigens. In particular, our emphasis was on identifying exclusive C-locus antigens or interlocus among A, B, and C The use monoclonal alloantibodies eluted from recombinant single cell lines tested with a panel beads have proved very useful in identification epitopes.Alloantibodies absorbed onto then were 95 A-, B-, C- specificities determined. Each...
The MiT family comprises four genes in mammals: Mitf, Tfe3, Tfeb, and Tfec, which encode transcription factors of the basic-helix-loop-helix/leucine zipper class. Mitf is well-known for its essential role development melanocytes, however functions other members this family, interactions between them, are less well understood. We have now characterized complete set from zebrafish, totals six instead four. zebrafish genome contain two mitf (mitfa mitfb), tfe3 (tfe3a tfe3b), single tfeb tfec...
Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional therapeutic approaches. However, studies on genetic alterations EGFR Her2 status of apocrine-eccrine few in number. In addition, hormonal have not been comprehensive performed only certain subsets carcinomas. To investigate whether express receptors or possess activation...